Narrowband Biphoton Generation due to Long-Lived Coherent Population Oscillations

We study the generation of paired photons due to the effect of four-wave mixing in an ensemble of pumped two-level systems that decay via an intermediate metastable state. The slow population relaxation of the metastable state to the ground state is utilized to create long-lived coherent population oscillation, leading to narrowband nonlinear response of the medium. The biphotons have a narrow bandwidth, long coherence time and length, which can be controlled by the pump field. In addition, the biphotons are antibunched, with antibunching period determined by the dephasing time. During this period, damped oscillations of the biphoton wavefunction occurs if the pump detuning is non-zero.Comment: 7 pages, 2 figure

Orientation-to-alignment conversion and spin squeezing

The relationship between orientation-to-alignment conversion (a form of atomic polarization evolution induced by an electric field) and the phenomenon of spin squeezing is demonstrated. A "stretched" state of an atom or molecule with maximum angular-momentum projection along the quantization axis possesses orientation and is a quantum-mechanical minimum-uncertainty state, where the product of the equal uncertainties of the angular-momentum projections on two orthogonal directions transverse to the quantization axis is the minimum allowed by the uncertainty relation. Application of an electric field for a short time induces orientation-to-alignment conversion and produces a spin-squeezed state, in which the quantum state essentially remains a minimum-uncertainty state, but the uncertainties of the angular-momentum projections on the orthogonal directions are unequal. This property can be visualized using the angular-momentum probability surfaces, where the radius of the surface is given by the probability of measuring the maximum angular-momentum projection in that direction. Brief remarks are also given concerning collective-spin squeezing and quantum nondemolition measurements.Comment: 7 pages, 6 figure

Dissecting the origin of the submillimeter emission in nearby galaxies with Herschel and LABOCA

We model the infrared to submillimeter spectral energy distribution of 11 nearby galaxies of the KINGFISH sample using Spitzer and Herschel data and compare model extrapolations at 870um (using different fitting techniques) with LABOCA 870um observations. We investigate how the differences between predictions and observations vary with model assumptions or environment. At global scales, we find that modified blackbody models using realistic cold emissivity indices (beta_c=2 or 1.5) are able to reproduce the 870um observed emission within the uncertainties for most of the sample. Low values (beta_c<1.3) would be required in NGC0337, NGC1512 and NGC7793. At local scales, we observe a systematic 870um excess when using beta_=2.0. The beta_c=1.5 or the Draine and Li (2007) models can reconcile predictions with observations in part of the disks. Some of the remaining excesses occur towards the centres and can be partly or fully accounted for by non-dust contributions such as CO(3-2) or, to a lesser extent, free-free or synchrotron emission. In three non-barred galaxies, the remaining excesses rather occur in the disk outskirts. This could be a sign of a flattening of the submm slope (and decrease of the effective emissivity index) with radius in these objects.Comment: 31 pages (including appendix), 7 figures, accepted for publication in MNRA

Pancreatic cysts suspected to be branch duct intraductal papillary mucinous neoplasm without concerning features have low risk for development of pancreatic cancer.

BackgroundThe risk of developing pancreatic cancer is uncertain in patients with clinically suspected branch duct intraductal papillary mucinous neoplasm (BD-IPMN) based on the "high-risk stigmata" or "worrisome features" criteria proposed in the 2012 international consensus guidelines ("Fukuoka criteria").MethodsRetrospective case series involving patients referred for endoscopic ultrasound (EUS) of indeterminate pancreatic cysts with clinical and EUS features consistent with BD-IPMN. Rates of pancreatic cancer occurring at any location in the pancreas were compared between groups of patients with one or more Fukuoka criteria ("Highest-Risk Group", HRG) and those without these criteria ("Lowest-Risk Group", LRG).ResultsAfter exclusions, 661 patients comprised the final cohort (250 HRG and 411 LRG patients), 62% female with an average age of 67 years and 4 years of follow up. Pancreatic cancer, primarily adenocarcinoma, occurred in 60 patients (59 HRG, 1 LRG). Prevalent cancers diagnosed during EUS, immediate surgery, or first year of follow up were found in 48/661 (7.3%) of cohort and exclusively in HRG (33/77, 42.3%). Using Kaplan-Meier method, the cumulative incidence of cancer at 7 years was 28% in HRG and 1.2% in LRG patients (P&lt;0.001).ConclusionsThis study supports using Fukuoka criteria to stratify the immediate and long-term risks of pancreatic cancer in presumptive BD-IPMN. The risk of pancreatic cancer was highest during the first year and occurred exclusively in those with "high-risk stigmata" or "worrisome features" criteria. After the first year all BD-IPMN continued to have a low but persistent cancer risk

Activation of an Endogenous Retrovirus-Associated Long Non-Coding RNA in Human Adenocarcinoma

Background Long non-coding RNAs (lncRNAs) are emerging as molecules that significantly impact many cellular processes and have been associated with almost every human cancer. Compared to protein-coding genes, lncRNA genes are often associated with transposable elements, particularly with endogenous retroviral elements (ERVs). ERVs can have potentially deleterious effects on genome structure and function, so these elements are typically silenced in normal somatic tissues, albeit with varying efficiency. The aberrant regulation of ERVs associated with lncRNAs (ERV-lncRNAs), coupled with the diverse range of lncRNA functions, creates significant potential for ERV-lncRNAs to impact cancer biology. Methods We used RNA-seq analysis to identify and profile the expression of a novel lncRNA in six large cohorts, including over 7,500 samples from The Cancer Genome Atlas (TCGA). Results We identified the tumor-specific expression of a novel lncRNA that we have named Endogenous retroViral-associated ADenocarcinoma RNA or ‘EVADR’, by analyzing RNA-seq data derived from colorectal tumors and matched normal control tissues. Subsequent analysis of TCGA RNA-seq data revealed the striking association of EVADR with adenocarcinomas, which are tumors of glandular origin. Moderate to high levels of EVADR were detected in 25 to 53% of colon, rectal, lung, pancreas and stomach adenocarcinomas (mean&thinsp;=&thinsp;30 to 144 FPKM), and EVADR expression correlated with decreased patient survival (Cox regression; hazard ratio&thinsp;=&thinsp;1.47, 95% confidence interval&thinsp;=&thinsp;1.06 to 2.04, P&thinsp;=&thinsp;0.02). In tumor sites of non-glandular origin, EVADR expression was detectable at only very low levels and in less than 10% of patients. For EVADR, a MER48 ERV element provides an active promoter to drive its transcription. Genome-wide, MER48 insertions are associated with nine lncRNAs, but none of the MER48-associated lncRNAs other than EVADR were consistently expressed in adenocarcinomas, demonstrating the specific activation of EVADR. The sequence and structure of the EVADR locus is highly conserved among Old World monkeys and apes but not New World monkeys or prosimians, where the MER48 insertion is absent. Conservation of the EVADR locus suggests a functional role for this novel lncRNA in humans and our closest primate relatives. Conclusions Our results describe the specific activation of a highly conserved ERV-lncRNA in numerous cancers of glandular origin, a finding with diagnostic, prognostic and therapeutic implications

Generalized Numerical Renormalization Group for Dynamical Quantities

In this paper we introduce a new approach for calculating dynamical properties within the numerical renormalization group. It is demonstrated that the method previously used fails for the Anderson impurity in a magnetic field due to the absence of energy scale separation. The problem is solved by evaluating the Green function with respect to the reduced density matrix of the full system, leading to accurate spectra in agreement with the static magnetization. The new procedure (denoted as DM-NRG) provides a unifying framework for calculating dynamics at any temperature and represents the correct extension of Wilson's original thermodynamic calculation.Comment: 4 pages RevTeX, 6 eps figures include

Kondo effect in a magnetic field and the magnetoresistivity of Kondo alloys

The effect of a magnetic field on the spectral density of a $\rm{S=1/2}$ Kondo impurity is investigated at zero and finite temperatures by using Wilson's numerical renormalization group method. A splitting of the total spectral density is found for fields larger than a critical value $H_{c}(T=0)\approx 0.5 T_{K}$, where $T_{K}$ is the Kondo scale. The splitting correlates with a peak in the magnetoresistivity of dilute magnetic alloys which we calculate and compare with the experiments on $\rm{Ce_{x}La_{1-x}Al_{2}}, x=0.0063$. The linear magnetoconductance of quantum dots exhibiting the Kondo effect is also calculated.Comment: 4 pages, 4 eps figure

Searching for O2_2 in the SMC:Constraints on Oxygen Chemistry at Low Metallicities

We present a 39 h integration with the Odin satellite on the ground-state 118.75 GHz line of O2 towards the region of strongest molecular emission in the Small Magellanic Cloud. Our 3sigma upper limit to the O2 integrated intensity of <0.049 K km/s in a 9'(160 pc) diameter beam corresponds to an upper limit on the O2/H2 abundance ratio of <1.3E-6. Although a factor of 20 above the best limit on the O2 abundance obtained for a Galactic source, our result has interesting implications for understanding oxygen chemistry at sub-solar metal abundances. We compare our abundance limit to a variety of astrochemical models and find that, at low metallicities, the low O2 abundance is most likely produced by the effects of photo-dissociation on molecular cloud structure. Freeze-out of molecules onto dust grains may also be consistent with the observed abundance limit, although such models have not yet been run at sub-solar initial metallicities.Comment: 4 pages, accepted to A&A Letter