Studying the Child Obesity Epidemic with Natural Experiments

We utilize clinical records of successive visits by children to pediatric clinics in Indianapolis to estimate the effects on their body mass of environmental changes near their homes. We compare results for fixed-residence children with those for cross-sectional data. Our environmental factors are fast food restaurants, supermarkets, parks, trails, and violent crimes, and 13 types of recreational amenities derived from the interpretation of annual aerial photographs. We looked for responses to these factors changing within buffers of 0.1, 0.25, 0.5, and 1 mile. We found that cross-sectional estimates are quite different from the Fixed Effects estimates of the impacts of amenities locating near a child. In cross section nearby fast food restaurants were associated with higher BMI and supermarkets with lower BMI. These results were reversed in the FE estimates. The recreational amenities that appear to lower children's BMI were fitness areas, kickball diamonds, and volleyball courts. We estimated that locating these amenities near their homes could reduce the weight of an overweight eight-year old boy by 3 to 6 pounds

Financial literacy and responsible finance in the FinTech era : capabilities and challenges

Panos gratefully acknowledges funding from the PROFIT project. Project PROFIT has received funding from the European Union’s Horizon 2020 Framework Programme for Research and Innovation under grant agreement no. 687895.A growing body of evidence suggests that financial literacy plays an important role in financial well-being, and that differences in financial knowledge acquired early in life can explain a significant part of financial and more general well-being in adult life. Financial technology (FinTech) is revolutionising the financial services industry at an unrivalled pace. Views differ regarding the likely impact that FinTech is likely to have on personal financial planning, well-being and societal welfare. In an era of mounting student debt, increased (digital) financial inclusion, and threats arising from instances of (online) financial fraud, financial education and enlightened financial advising appropriate policy interventions that enhance financial and overall well-being. This special issue engages in this important academic and policy agenda by presenting a set of seven new papers emanating from four parallel streams of literature related to financial literacy and responsible finance.PostprintPeer reviewe

How does credit supply react to a natural disaster? Evidence from the Indian Ocean Tsunami

The supply of credit may increase or decrease following a natural disaster, depending on the extent to which banks can absorb risk, and the economic prospects and demand for finance by affected firms and households. In this paper, we assess the impact of a natural disaster (Indian Ocean Tsunami of 2004) on the aggregate supply of credit to provinces throughout Thailand. The results of our investigation suggest that the tsunami has long-lasting negative effects on bank lending, albeit the effects are spread unevenly across geographic areas with most of the reduction in aggregate lending occurring in severely affected provinces. We also find that the presence of bank branches in affected regions mitigates some of the adverse lending effects that follow the tsunami.PostprintPeer reviewe

Methane flux from the Central Amazonian Floodplain

A total of 186 methane measurements from the three primary Amazon floodplain environments of open water lakes, flood forests, and floating grass mats were made over the period 18 July through 2 September 1985. These data indicate that emissions were lowest over open water lakes. Flux from flooded forests and grass mats was significantly higher. At least three transport processes contribute to tropospheric emissions: ebullition from sediments, diffusion along the concentration gradient from sediment to overlaying water to air, and transport through the roots and stems of aquatic plants. Measurements indicate that the first two of these processes are most significant. It was estimated that on the average bubbling makes up 49% of the flux from open water, 54% of that from flooded forests, and 64% of that from floating mats. If the measurements were applied to the entire Amazonian floodplain, it is calculated that the region could supply up to 12% of the estimated global natural sources of methane

Racial Bias in Judgments of Physical Size and Formidability: From Size to Threat

Black men tend to be stereotyped as threatening and, as a result, may be disproportionately targeted by police even when unarmed. Here, we found evidence that biased perceptions of young Black men\u27s physical size may play a role in this process. The results of 7 studies showed that people have a bias to perceive young Black men as bigger (taller, heavier, more muscular) and more physically threatening (stronger, more capable of harm) than young White men. Both bottom-up cues of racial prototypicality and top-down information about race supported these misperceptions. Furthermore, this racial bias persisted even among a target sample from whom upper-body strength was controlled (suggesting that racial differences in formidability judgments are a product of bias rather than accuracy). Biased formidability judgments in turn promoted participants\u27 justifications of hypothetical use of force against Black suspects of crime. Thus, perceivers appear to integrate multiple pieces of information to ultimately conclude that young Black men are more physically threatening than young White men, believing that they must therefore be controlled using more aggressive measures

Neuregulin-1 attenuates mortality associated with experimental cerebral malaria.

BackgroundCerebral Malaria (CM) is a diffuse encephalopathy caused by Plasmodium falciparum infection. Despite availability of antimalarial drugs, CM-associated mortality remains high at approximately 30% and a subset of survivors develop neurological and cognitive disabilities. While antimalarials are effective at clearing Plasmodium parasites they do little to protect against CM pathophysiology and parasite-induced brain inflammation that leads to seizures, coma and long-term neurological sequelae in CM patients. Thus, there is urgent need to explore therapeutics that can reduce or prevent CM pathogenesis and associated brain inflammation to improve survival. Neuregulin-1 (NRG-1) is a neurotrophic growth factor shown to protect against brain injury associated with acute ischemic stroke (AIS) and neurotoxin exposure. However, this drug has not been tested against CM-associated brain injury. Since CM-associated brain injuries and AIS share similar pathophysiological features, we hypothesized that NRG-1 will reduce or prevent neuroinflammation and brain damage as well as improve survival in mice with late-stage experimental cerebral malaria (ECM).MethodsWe tested the effects of NRG-1 on ECM-associated brain inflammation and mortality in P. berghei ANKA (PbA)-infected mice and compared to artemether (ARM) treatment; an antimalarial currently used in various combination therapies against malaria.ResultsTreatment with ARM (25 mg/kg/day) effectively cleared parasites and reduced mortality in PbA-infected mice by 82%. Remarkably, NRG-1 therapy (1.25 ng/kg/day) significantly improved survival against ECM by 73% despite increase in parasite burden within NRG-1-treated mice. Additionally, NRG-1 therapy reduced systemic and brain pro-inflammatory factors TNFalpha, IL-6, IL-1alpha and CXCL10 and enhanced anti-inflammatory factors, IL-5 and IL-13 while decreasing leukocyte accumulation in brain microvessels.ConclusionsThis study suggests that NRG-1 attenuates ECM-associated brain inflammation and injuries and may represent a novel supportive therapy for the management of CM