Online Mapping Tools for Geolocating Amish Settlements

This technical note demonstrates the value of using online mapping tools as a method of geolocating Amish settlements. Primarily using freely available Bing and Google maps and published lists of the addresses of Amish ministers, we geolocated 1,362 Amish households in Ohio and 1,203 in Pennsylvania, representing about 10% of Amish households in those states. From these data we were able to derive a population density map of the Amish across Ohio and Pennsylvania. We caution that our map is merely a model and based on several assumptions, but the product is a finer resolution map of Amish distribution than has previously been published. We add that the locations of Amish schools provide another promising avenue for geolocation of Amish settlements, but we were not able to locate sufficiently comprehensive lists to include them in our analysis

Fish surveys on the Leven and Kent estuaries

This is the Wetland resource evaluation and the NRA's role in its conservation: Resource assessment report produced by North West Water in 1982. In this report data from a variety of sources in river Leven and Leven estuary have been examined to determine if there was any objective foundation for the allegations and for the assertion that poor fish catches were related to discharges of industrial effluent to the estuary. Catches of salmon and sea trout from the Leven did not appear to have suffered any long term declines and year to year fluctuations did not appear to be any more extreme than in other North West rivers. Fish surveys did not show any marked differences in the diversity or distribution of fish between the Kent and Leven estuaries but catches of flounders were consistently lower from the Leven estuary. Analysis of fisheries statistics of landings of fish and shellfish from Morecambe Bay did not show any evidence of localised declines in catches from the Leven estuary. Results of laboratory experiments suggested that populations of bivalve molluscs might be more at risk from the effects of discharges to the Leven estuary than resident or migratory fish

Evidence for strong evolution in galaxy environmental quenching efficiency between z = 1.6 and z = 0.9

Indexación: Web of Science; Scopus.We analyse the evolution of environmental quenching efficiency, the fraction of quenched cluster galaxies which would be star forming if they were in the field, as a function of redshift in 14 spectroscopically confirmed galaxy clusters with 0.87 < z < 1.63 from the Spitzer Adaptation of the Red-Sequence Cluster Survey. The clusters are the richest in the survey at each redshift. Passive fractions rise from 42-13 +10 per cent at z ~ 1.6 to 80-9 +12 per cent at z ~ 1.3 and 88-3 +4 per cent at z < 1.1, outpacing the change in passive fraction in the field. Environmental quenching efficiency rises dramatically from 16-19 +15 per cent at z ~ 1.6 to 62-15 +21 per cent at z~1.3 and 73-7 +8 per cent at z ≲ 1.1. This work is the first to show direct observational evidence for a rapid increase in the strength of environmental quenching in galaxy clusters at z ~ 1.5, where simulations show cluster-mass haloes undergo non-linear collapse and virialization.https://academic.oup.com/mnrasl/article/465/1/L104/241728

Immune checkpoint inhibitors: new strategies to checkmate cancer

Immune checkpoint inhibitors (ICIs) targeting Cytotoxic T-Lymphocyte-Associated protein 4 (CTLA-4) or Programmed cell Death protein 1 (PD-1) receptors have demonstrated remarkable efficacy in subsets of patients with malignant disease. This emerging treatment modality holds great promise for future cancer treatment and has engaged pharmaceutical research interests in tumour immunology. While ICIs can induce rapid and durable responses in some patients, identifying predictive factors for effective clinical responses has proven challenging. This review summarises the mechanisms of action of ICIs and outlines important pre-clinical work that contributed to their development. We explore clinical data that has led to disease-specific drug licensing, and highlight key clinical trials that have revealed ICI efficacy across a range of malignancies. We describe how ICIs have been used as part of combination therapies, and explore their future prospects in this area. We conclude by discussing the incorporation of these new immunotherapeutics into precision approaches to cancer therapy

Very long optical path-length from a compact multi-pass cell

The multiple-pass optical cell is an important tool for laser absorption spectroscopy and its many applications. For most practical applications, such as trace-gas detection, a compact and robust design is essential. Here we report an investigation into a multi-pass cell design based on a pair of cylindrical mirrors, with a particular focus on achieving very long optical paths. We demonstrate a path-length of 50.31 m in a cell with 40 mm diameter mirrors spaced 88.9 mm apart - a 3-fold increase over the previously reported longest path-length obtained with this type of cell configuration. We characterize the mechanical stability of the cell and describe the practical conditions necessary to achieve very long path-lengths

Light Quark Simulations With FLIC Fermions

Hadron masses are calculated in quenched lattice QCD in order to probe the scaling behavior of a novel fat-link clover fermion action in which only the irrelevant operators of the fermion action are constructed using APE-smeared links. Light quark masses corresponding to an m_pi / m_rho ratio of 0.35 are considered to assess the exceptional configuration problem of clover-fermion actions. This Fat-Link Irrelevant Clover (FLIC) fermion action provides scaling which is superior to mean-field improvement and offers advantages over nonperturbative improvement, including reduced exceptional configurations.Comment: 3 pages, 2 figures, Lattice2002(QCD Spectrum and Quark Masses

Incorporating Weisfeiler-Leman into algorithms for group isomorphism

In this paper we combine many of the standard and more recent algebraic techniques for testing isomorphism of finite groups (GpI) with combinatorial techniques that have typically b

The atypical chemokine receptor Ackr2 constrains NK cell migratory activity and promotes metastasis

Chemokines have been shown to be essential players in a range of cancer contexts. In this study, we demonstrate that mice deficient in the atypical chemokine receptor Ackr2 display impaired development of metastasis in vivo in both cell line and spontaneous models. Further analysis reveals that this relates to increased expression of the chemokine receptor CCR2, specifically by KLRG1+ NK cells from the Ackr2−/− mice. This leads to increased recruitment of KLRG1+ NK cells to CCL2-expressing tumors and enhanced tumor killing. Together, these data indicate that Ackr2 limits the expression of CCR2 on NK cells and restricts their tumoricidal activity. Our data have important implications for our understanding of the roles for chemokines in the metastatic process and highlight Ackr2 and CCR2 as potentially manipulable therapeutic targets in metastasis

The Onderstepoort small animal colony

The articles have been scanned in colour with a HP Scanjet 5590; 300dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format