The Challenge Of Creating And Maintaining Respected Country-Of-Origin Assets: The Irish Linen Story

The idea that country images and brand images can be strongly linked is well accepted in international marketing (Paswan et al, 2003; Al-Sulaiti and Baker, 1998; Li and Murray, 2000; Zhang, 1997). A country image projected to the rest of the world is very complex (O’Shaughnessy and O’Shaughnessy, 2000; Insch and McBride, 2002) and multidimensional (Papadopoulos and Heslop, 2002). Some products and their countries are linked so strongly that the brand images include their country of origin (COO).  Certain Irish products have such a linkage.  A Chicago Tribune article observes that when tourists go to Ireland they often are unable to resist buying fine handmade products that are known worldwide for their quality, such as Aran sweaters, Irish linen and lace, tweeds, Waterford crystal, Belleek china, and Celtic motif jewelry and pewter (Merin, 1991).  Of those fine products, linen is inseparably linked with the nation as Irish linen.  Irish linen is now a brand name that yields the benefits and problems inherent with brand status and subject to the influences of country of image effects

Differential Prepartum and Postpartum Growth Patterns of Yorkshire and Meishan Piglets Gestated in the Same Uterine Environment

While Yorkshire fetal growth appears to depend on increasing placental size, more extensive vascularization of a smaller placenta appears to support Meishan fetal growth. Further studies are needed to extend our knowledge of the mechanisms controlling placental growth and vascularization. The ability to manipulate conceptus size may allow producers the opportunity to increase litter size in domestic pigs. More piglets farrowed per sow per year combined with the effects of fetal genotype on postpartum growth rate, as confirmed by the current study, would allow more efficient pork production

A Decreased Placental Size and Increased Vascular Density Results in Increased Prolificacy in the Meishan Pig

The Chinese Meishan pig farrows 3 to 5 more pigs per litter than U.S. pig breeds. When Meishan and Yorkshire embryos are co-transferred to a Yorkshire recipient, Meishan fetuses and placentae are smaller than Yorkshire fetuses and placentae through day 90 of gestation. At farrowing, Meishan placentae are still smaller than Yorkshire placentae; however, Meishan fetuses are born at the same weight as their Yorkshire littermates. This tremendous growth of the Meishan fetus between day 90 and term is the result of an increased vascularization of the Meishan placenta. In this experiment we investigated the time course of placental vascular development of Meishan and Yorkshire conceptuses during late gestation. Our results demonstrate that Yorkshire fetuses increase the potential for nutrient extraction from the maternal blood by increasing the size of their placentae; however, Meishan fetuses achieve the same end by increasing the density of placental blood vessels while maintaining a constant placental size. The increased vascular density of the Meishan placenta then allows the conceptus to occupy less space in the uterus, allowing more fetuses to survive to term

Acoustic-to-Articulatory Speech Inversion Features for Mispronunciation Detection of /r/ in Child Speech Sound Disorders

Acoustic-to-articulatory speech inversion could enhance automated clinical mispronunciation detection to provide detailed articulatory feedback unattainable by formant-based mispronunciation detection algorithms; however, it is unclear the extent to which a speech inversion system trained on adult speech performs in the context of (1) child and (2) clinical speech. In the absence of an articulatory dataset in children with rhotic speech sound disorders, we show that classifiers trained on tract variables from acoustic-to-articulatory speech inversion meet or exceed the performance of state-of-the-art features when predicting clinician judgment of rhoticity. Index Terms: rhotic, speech sound disorder, mispronunciation detectionComment: *denotes equal contribution. To appear in Proceedings of the Annual Conference of the International Speech Communication Association, INTERSPEECH 202

Modification of the Mycotoxin Deoxynivalenol Using Microorganisms Isolated from Environmental Samples

The trichothecene mycotoxin deoxynivalenol (DON) is a common contaminant of wheat, barley, and maize. New strategies are needed to reduce or eliminate DON in feed and food products. Microorganisms from plant and soil samples collected in Blacksburg, VA, USA, were screened by incubation in a mineral salt media containing 100 μg/mL DON and analysis by gas chromatography mass spectrometry (GC/MS). Two mixed cultures derived from soil samples consistently decreased DON levels in assays using DON as the sole carbon source. Nuclear magnetic resonance (NMR) analysis indicated that 3-keto-4-deoxynivalenol was the major by-product of DON. Via 16S rRNA sequencing, these mixed cultures, including mostly members of the genera Acinetobacter, Leadbetterella, and Gemmata, were revealed. Incubation of one of these mixed cultures with wheat samples naturally contaminated with 7.1 μg/mL DON indicated nearly complete conversion of DON to the less toxic 3-epimer-DON (3-epi-DON). Our work extends previous studies that have demonstrated the potential for bioprospecting for microorganisms from the environment to remediate or modify mycotoxins for commercial applications, such as the reduction of mycotoxins in fuel ethanol co-products

Action comprehension in aphasia: linguistic and non-linguistic deficits and their lesion correlates.

Abstract We tested aphasic patients' comprehension of actions to examine processing deficits in the linguistic and non-linguistic domains and their lesion correlates. Twenty-nine left-hemisphere injured patients and 18 age-matched control subjects matched pictured actions (with the objects missing) or their linguistic equivalents (printed sentences with the object missing) to one of two visually-presented pictures of objects. Aphasic patients performed poorly not only in the linguistic domain but also in the non-linguistic domain. A subset of the patients, largely consisting of severe and non-fluent aphasics, showed a greater deficit in the linguistic domain compared with the non-linguistic domain and across the patient group, deficits in the linguistic and non-linguistic domains were not tightly correlated. Poor performance in pantomime interpretation was associated with lesions in the inferior frontal, premotor and motor cortex, a portion of somatosensory cortex, and the caudate, while poor reading comprehension of actions was associated with lesions around the anterior superior temporal lobe, the anterior insula and the anterior portion of the inferior parietal lobe. Lesion size did not correlate with deficits. The lesion results for pantomime interpretation deficits demonstrate that lesions in the frontal component of the human analog of the "mirror neuron system" are associated with deficits in non-linguistic action understanding. For reading comprehension deficits, the lesion correlates are brain areas known to be involved in linguistic tasks including sentence processing and speech articulation; the parietal lesion site may also correspond to a subpart of the human mirror neuron system. These results indicate that brain areas important for the production of language and action are also recruited in their comprehension. Similar findings have been reported in electrophysiological and neuroimaging studies. Our findings now also lend neuropsychological support to an embodied view of brain organization for action processing

Biochemical analysis of novel NAA10 variants suggests distinct pathogenic mechanisms involving impaired protein N-terminal acetylation

NAA10 is the catalytic subunit of the N-terminal acetyltransferase complex, NatA, which is responsible for N-terminal acetylation of nearly half the human proteome. Since 2011, at least 21 different NAA10 missense variants have been reported as pathogenic in humans. The clinical features associated with this X-linked condition vary, but commonly described features include developmental delay, intellectual disability, cardiac anomalies, brain abnormalities, facial dysmorphism and/or visual impairment. Here, we present eight individuals from five families with five different de novo or inherited NAA10 variants. In order to determine their pathogenicity, we have performed biochemical characterisation of the four novel variants c.16G>C p.(A6P), c.235C>T p.(R79C), c.386A>C p.(Q129P) and c.469G>A p.(E157K). Additionally, we clinically describe one new case with a previously identified pathogenic variant, c.384T>G p.(F128L). Our study provides important insight into how different NAA10 missense variants impact distinct biochemical functions of NAA10 involving the ability of NAA10 to perform N-terminal acetylation. These investigations may partially explain the phenotypic variability in affected individuals and emphasise the complexity of the cellular pathways downstream of NAA10.publishedVersio

Verbal Memory Performance and Reduced Cortical Thickness of Brain Regions Along the Uncinate Fasciculus in Young Adult Cannabis Users

Abstract Introduction: Memory impairment is one of the most commonly reported effects of cannabis use, especially among those who initiate use earlier, perhaps due to the effects of delta-9- tetrahydrocannabinol on cannabinoid (CB1) receptors in the brain. Studies have increasingly investigated whether cannabis use is associated with impairments in verbal memory, and with alterations in brain structures underlying verbal memory. The uncinate fasciculus (UF), a long-range white matter tract, connects regions with densely localized CB1 receptors that are important in verbal memory. This study investigated the impact of cannabis use on UF structures and its association with memory performance in young adult cannabis users (CU) and non-using controls (CON). Materials and Methods: Nineteen CU and 22 CON completed a verbal memory task and a neuroimaging protocol, in which diffusion tensor imaging and structural scans were collected. We compared memory performance, diffusion and tractography measures of the UF, and cortical thickness of regions connected by the UF, between CU and CON. In regions showing a significant group effect, we also examined associations between verbal memory performance, cortical thickness, and age of onset of cannabis use. Results: Compared to non-users, CU had worse memory performance, decreased fiber bundle length in the UF, and decreased cortical thickness of brain regions along the UF such as the entorhinal cortex and fusiform gyrus. Verbal memory performance was significantly associated with age of onset of cannabis use, indicating that those who initiated cannabis use at an earlier age performed worse. Cortical thickness of the entorhinal cortex was significantly correlated with age of first use and memory performance. Conclusion: This study provides evidence that cannabis use, especially when initiated at a young age, may be associated with worse verbal memory and altered neural development along the UF. Reductions in cortical thickness in regions implicated in memory processes may underlie weaknesses in verbal memory performance

Improving the relationships between Indigenous rights holders and researchers in the Arctic: an invitation for change in funding and collaboration

Truly transdisciplinary approaches are needed to tackle the complex problems that the Arctic is facing at the moment. Collaboration between Indigenous rights holders and researchers through co-creative research approaches can result in high-quality research outcomes, but crucially also address colonial legacies and power imbalances, enhance mutual trust, and respect the rights of Indigenous Peoples. However, to be successful, collaborative research projects have specific requirements regarding research designs, timeframes, and dissemination of results, which often do not fit into the frameworks of academic calendars and funding guidelines. Funding agencies in particular play an important role in enabling (or disabling) meaningful collaboration between Indigenous rights holders and researchers. There is an urgent need to re-think existing funding-structures. This article will propose a new paradigm for the financing of Arctic research, which centres around the inclusion of Indigenous partners, researchers, and institutions from the initial planning stages of funding programmes to the final stages of research projects. These findings and recommendations have been contextualized based on critical reflections of the co-authors, a group of Indigenous and non-Indigenous partners, who have practiced their own collaborative work process, the challenges encountered, and lessons learned