Mean-Motion Resonances of High Order in Extrasolar Planetary Systems

Many multi-planet systems have been discovered in recent years. Some of them are in mean-motion resonances (MMR). Planet formation theory was successful in explaining the formation of 2:1, 3:1 and other low resonances as a result of convergent migration. However, higher order resonances require high initial orbital eccentricities in order to be formed by this process and these are in general unexpected in a dissipative disk. We present a way of generating large initial eccentricities using additional planets. This procedure allows us to form high order MMRs and predict new planets using a genetic N-body code.Comment: To appear in Proceedings: Extrasolar Planets in Multi-body Systems: Theory and Observations; Editors K. Gozdziewski, A. Niedzielski and J. Schneider; 5 pages, 2 figures

Synthetic Methods for the Preparation of Platinum Anticancer Complexes

The demonstration in the 1960s that cis-diammine-dichloroplatinum(II), or cisplatin, inhibits cellular division of Escherichia coli led to the subsequent discovery that this simple coordination compound is also an effective antitumor agent in mouse models. Subsequent studies validated cisplatin as an effective anticancer agent in humans as well, and FDA approval of cisplatin for the treatment of metastatic ovarian and testicular cancers was granted in 1978. Its introduction as a chemotherapeutic agent significantly improved the survival outlook for many cancer patients; the cure rate for testicular cancer before the approval of cisplatin was less than 10%, significantly lower than the 90% cure rate attained with modern platinum chemotherapy.National Cancer Institute (U.S.) (Grant CA034992)David H. Koch Institute for Integrative Cancer Research at MIT (Graduate Fellowship

Condensation temperature of interacting Bose gases with and without disorder

The momentum-shell renormalization group (RG) is used to study the condensation of interacting Bose gases without and with disorder. First of all, for the homogeneous disorder-free Bose gas the interaction-induced shifts in the critical temperature and chemical potential are determined up to second order in the scattering length. The approach does not make use of dimensional reduction and is thus independent of previous derivations. Secondly, the RG is used together with the replica method to study the interacting Bose gas with delta-correlated disorder. The flow equations are derived and found to reduce, in the high-temperature limit, to the RG equations of the classical Landau-Ginzburg model with random-exchange defects. The random fixed point is used to calculate the condensation temperature under the combined influence of particle interactions and disorder.Comment: 7 pages, 2 figure

Modulation of ligand fluorescence by the Pt(II)/Pt(IV) redox couple

Dedicated to Professor Jon Zubieta on the occasion of his 65th birthday.The dangling carboxylic acid moiety of the known platinum(II) complex, [Pt(edma)Cl2] (edma = ethylenediaminemonoacetic acid), was functionalized via amide coupling chemistry with benzyl amine and dansyl ethylenediamine to afford the derivatives [Pt(edBz)Cl2] (1) and [Pt(edDs)Cl2] (2). Subsequent oxidation of these platinum(II) complexes with iodobenzene dichloride in DMF yielded the respective platinum(IV) analogs, [Pt(edBz)Cl4] (3) and [Pt(edDs)Cl4] (4). All four platinum complexes were characterized by multinuclear NMR spectroscopy, IR spectroscopy, electrospray ionization mass spectrometry, and elemental analysis. In addition, compounds 1 and 3 were structurally characterized by X-ray crystallography. The photophysical properties of the compounds bearing the fluorescent dansyl moiety, 2 and 4, were evaluated. The emission quantum yields of 2 and 4 in DMF are 27% and 1.6%, respectively. This large difference in emission efficiency indicates that the platinum(IV) center in 4 is more effective at quenching the dansyl-based fluorescence than the platinum(II) center in 2. Time-dependent density functional theory calculations indicate that 4 has several low-lying singlet excited states that energetically lie below the primary radiation-accessible excited state of the dansyl fluorophore. These low-energy excited states may offer non-radiative decay pathways that lower the overall emission quantum yield. Treatment of 4 with biologically relevant reducing agents in pH 7.4 phosphate-buffered saline induces a 6.3-fold increase in emission intensity. These results demonstrate that 4 and future derivatives thereof may be useful for imaging the reduction of platinum(IV) complexes in living systems, chemistry of importance for evolving platinum-based anticancer drug strategies.National Cancer Institute (U.S.) (grant CA034992)National Institutes of Health (U.S.) (NIH Grant 1S10RR13886-01

Massively Parallel Signal Processing using the Graphics Processing Unit for Real-Time Brain–Computer Interface Feature Extraction

The clock speeds of modern computer processors have nearly plateaued in the past 5 years. Consequently, neural prosthetic systems that rely on processing large quantities of data in a short period of time face a bottleneck, in that it may not be possible to process all of the data recorded from an electrode array with high channel counts and bandwidth, such as electrocorticographic grids or other implantable systems. Therefore, in this study a method of using the processing capabilities of a graphics card [graphics processing unit (GPU)] was developed for real-time neural signal processing of a brain–computer interface (BCI). The NVIDIA CUDA system was used to offload processing to the GPU, which is capable of running many operations in parallel, potentially greatly increasing the speed of existing algorithms. The BCI system records many channels of data, which are processed and translated into a control signal, such as the movement of a computer cursor. This signal processing chain involves computing a matrix–matrix multiplication (i.e., a spatial filter), followed by calculating the power spectral density on every channel using an auto-regressive method, and finally classifying appropriate features for control. In this study, the first two computationally intensive steps were implemented on the GPU, and the speed was compared to both the current implementation and a central processing unit-based implementation that uses multi-threading. Significant performance gains were obtained with GPU processing: the current implementation processed 1000 channels of 250 ms in 933 ms, while the new GPU method took only 27 ms, an improvement of nearly 35 times

Rare regions and avoided quantum criticality in disordered Weyl semimetals and superconductors

Disorder in Weyl semimetals and superconductors is surprisingly subtle, attracting attention and competing theories in recent years. In this brief review, we discuss the current theoretical understanding of the effects of short-ranged, quenched disorder on the low energy-properties of three-dimensional, topological Weyl semimetals and superconductors. We focus on the role of non-perturbative rare region effects on destabilizing the semimetal phase and rounding the expected semimetal-to-diffusive metal transition into a cross over. Furthermore, the consequences of disorder on the resulting nature of excitations, transport, and topology are reviewed. New results on a bipartite random hopping model are presented that confirm previous results in a p+ip Weyl superconductor, demonstrating that particle–hole symmetry is insufficient to help stabilize the Weyl semimetal phase in the presence of disorder. The nature of the avoided transition in a model for a single Weyl cone in the continuum is discussed. We close with a discussion of open questions and future directions

Do the surface Fermi arcs in Weyl semimetals survive disorder?

We theoretically study the topological robustness of the surface physics induced by Weyl Fermi-arc surface states in the presence of short-ranged quenched disorder and surface-bulk hybridization. This is investigated with numerically exact calculations on a lattice model exhibiting Weyl Fermi-arcs. We find that the Fermi-arc surface states, in addition to having a finite lifetime from disorder broadening, hybridize with nonperturbative bulk rare states making them no longer bound to the surface (i.e. they lose their purely surface spectral character). Thus, we provide strong numerical evidence that the Weyl Fermi-arcs are not topologically protected from disorder. Nonetheless, the surface chiral velocity is robust and survives in the presence of strong disorder, persisting all the way to the Anderson-localized phase by forming localized current loops that live within the localization length of the surface. Thus, the Weyl semimetal is not topologically robust to the presence of disorder, but the surface chiral velocity is.Comment: Single column; 24 pages, 12 figure

Snatch trajectory of elite level girevoy (Kettlebell) sport athletes and its implications to strength and conditioning coaching

Girevoy sport (GS) has developed only recently in the West, resulting in a paucity of English scientific literature available. The aim was to document kettlebell trajectory of GS athletes performing the kettlebell snatch. Four elite GS athletes (age = 29-47 years, body mass = 68.3-108.1 kg, height 1.72-1.89 m) completed one set of 16 repetitions with a 32.1 kg kettlebell. Trajectory was captured with the VICON motion analysis system (250 Hz) and analysed with VICON Nexus (1.7.1). The kettlebell followed a ‘C’ shape trajectory in the sagittal plane. Mean peak velocity in the upwards phase was 4.03 ± 0.20 m s –1, compared to 3.70 ± 0.30 m s–1 during the downwards phase, and mean radial error across the sagittal and frontal planes was 0.022 ± 0.006 m. Low error in the movement suggests consistent trajectory is important to reduce extraneous movement and improve efficiency. While the kettlebell snatch and swing both require large anterior-posterior motion, the snatch requires the kettlebell to be held stationary overhead. Therefore, a different coaching application is required to that of a barbell snatch

Photoluminescent DNA binding and cytotoxic activity of a platinum(ii) complex bearing a tetradentate β-diketiminate ligand

A platinum(II) complex of a monoanionic, tetradentate β-diketiminate (BDI) ligand with pendant quinoline arms, BDIQQH, is reported. The complex, [Pt(BDI[superscript QQ])]Cl, is emissive in DMSO, but non-emissive in aqueous buffer. Upon binding DNA in buffer, however, a 150-fold turn-on in emission intensity occurs. Dynamic light scattering and [superscript 1]H NMR spectroscopy indicate that [Pt(BDI[superscript QQ])]Cl forms non-emissive aggregates in aqueous solution; DNA-binding disperses the aggregates leading to the large emission turn-on response. The cytotoxic activity of the complex, measured in two cancer cell lines, is comparable to or better than that of the established anticancer drug cisplatin.National Cancer Institute (U.S.) (Grant CA034992)David H. Koch Graduate FellowshipNational Institutes of Health (U.S.) (Grant 1S10RR13886

Potential roles of abundant extracellular chaperones in the control of amyloid formation and toxicity

The in vivo formation of fibrillar proteinaceous deposits called amyloid is associated with more than 40 serious human diseases, collectively referred to as protein deposition diseases. In many cases the amyloid deposits are extracellular and are found associated with newly identified abundant extracellular chaperones (ECs). Evidence is presented suggesting an important regulatory role for ECs in amyloid formation and disposal in the body. A model is presented which proposes that, under normal conditions, ECs stabilize extracellular misfolded proteins by binding to them, and then guide them to specific cell receptors for uptake and subsequent degradation. Thus ECs and their receptors may be critical parts of a quality control system to protect the body against dangerously hydrophobic proteins/peptides. However, it also appears possible that in the presence of a high molar excess of misfolded protein, such as might occur during disease, the limited amounts of ECs available may actually exacebate pathology. Further advances in understanding of the mechanisms that control extracellular protein folding are likely to identify new strategies for effective disease therapies