Reconciling diverse lacustrine and terrestrial system response to penultimate deglacial warming in southern Europe

Unlike the most recent deglaciation, the regional expression of climate changes during the penultimate deglaciation remains understudied, even though it led into a period of excess warmth with estimates of global average temperature 1–2 °C, and sea level ∼6 m, above pre-industrial values. We present the first complete high-resolution southern European diatom record capturing the penultimate glacial-interglacial transition, from Lake Ioannina (northwest Greece). It forms part of a suite of proxies selected to assess the character and phase relationships of terrestrial and aquatic ecosystem response to rapid climate warming, and to resolve apparent conflicts in proxy evidence for regional paleohydrology. The diatom data suggest a complex penultimate deglaciation driven primarily by multiple oscillations in lake level, and provide firm evidence for the regional influence of abrupt changes in North Atlantic conditions. There is diachroneity in lake and terrestrial ecosystem response to warming at the onset of the last interglacial, with an abrupt increase in lake level occurring ∼2.7 k.y. prior to sustained forest expansion with peak precipitation. We identify the potentially important role of direct input of snow melt and glacial meltwater transfer to the subterranean karst system in response to warming, which would cause rising regional groundwater levels. This explanation, and the greater sensitivity of diatoms to subtle changes in temperature, reconciles the divergent lacustrine and terrestrial proxy evidence and highlights the sensitivity of lakes situated in mountainous karstic environments to past climate warming

On the application of contemporary bulk sediment organic carbon isotope and geochemical datasets for Holocene sea-level reconstruction in NW Europe

Bulk organic stable carbon isotope (δ13C) and element geochemistry (total organic carbon (TOC) and organic carbon to total nitrogen (Corg/Ntot)) analysis is a developing technique in Holocene relative sea-level (RSL) research. The uptake of this technique in Northern Europe is limited compared to North America, where the common existence of coastal marshes with isotopically distinctive C3 and C4 vegetation associated with well defined inundation tolerance permits the reconstruction of RSL in the sediment record. In Northern Europe, the reduced range in δ13C values between organic matter sources in C3 estuaries can make the identification of elevation-dependent environments in the Holocene sediment record challenging and this is compounded by the potential for post-depositional alteration in bulk δ13C values. The use of contemporary regional δ13C, C/N and TOC datasets representing the range of physiographic conditions commonly encountered in coastal wetland sediment sequences opens up the potential of using absolute values of sediment geochemistry to infer depositional environments and associated reference water levels. In this paper, the application of contemporary bulk organic δ13C, C/N and TOC to reconstruct Holocene RSL is further explored. An extended contemporary regional geochemical dataset of published δ13C, C/N and TOC observations (n=142) from tidal-dominated C3 wetland deposits (representing tidal flat, saltmarsh, reedswamp and fen carr environments) in temperate NW Europe is compiled, and procedures implemented to correct for the 13C Suess effect on contemporary δ13C are detailed. Partitioning around medoids analysis identifies two distinctive geochemical groups in the NW European dataset, with tidal flat / saltmarsh and reedswamp / fen carr environments exhibiting characteristically different sediment δ13C, C/N and TOC values. A logistic regression model is developed from the NW European dataset in order to objectively identify in the sediment record geochemical groups and, more importantly, group transitions, thus allowing the altitude of reference water levels to be determined. The application of this method in RSL research is demonstrated using the Holocene sediments of the Mersey Estuary (UK), in which δ13C, C/N and TOC variability is typical of that encountered in Holocene sediments from C3 coastal wetlands in NW Europe. Group membership was predicted with high probability in the depositional contexts studied and the accuracy of group prediction is verified by microfossil evidence.The method presented facilitates the application of δ13C, C/N and TOC analysis in RSL reconstruction studies in C3 vegetated wetlands throughout temperate NW Europe

Visualizing electrostatic gating effects in two-dimensional heterostructures

The ability to directly observe electronic band structure in modern nanoscale field-effect devices could transform understanding of their physics and function. One could, for example, visualize local changes in the electrical and chemical potentials as a gate voltage is applied. One could also study intriguing physical phenomena such as electrically induced topological transitions and many-body spectral reconstructions. Here we show that submicron angle-resolved photoemission (micro-ARPES) applied to two-dimensional (2D) van der Waals heterostructures affords this ability. In graphene devices, we observe a shift of the chemical potential by 0.6 eV across the Dirac point as a gate voltage is applied. In several 2D semiconductors we see the conduction band edge appear as electrons accumulate, establishing its energy and momentum, and observe significant band-gap renormalization at low densities. We also show that micro-ARPES and optical spectroscopy can be applied to a single device, allowing rigorous study of the relationship between gate-controlled electronic and excitonic properties.Comment: Original manuscript with 9 pages with 4 figures in main text, 5 pages with 4 figures in supplement. Substantially edited manuscript accepted at Natur

Using step width to compare locomotor biomechanics between extinct, non-avian theropod dinosaurs and modern obligate bipeds

How extinct, non-avian theropod dinosaurs locomoted is a subject of considerable interest, as is the manner in which it evolved on the line leading to birds. Fossil footprints provide the most direct evidence for answering these questions. In this study, step width—the mediolateral (transverse) distance between successive footfalls—was investigated with respect to speed (stride length) in non-avian theropod trackways of Late Triassic age. Comparable kinematic data were also collected for humans and 11 species of ground-dwelling birds. Permutation tests of the slope on a plot of step width against stride length showed that step width decreased continuously with increasing speed in the extinct theropods (p < 0.001), as well as the five tallest bird species studied (p < 0.01). Humans, by contrast, showed an abrupt decrease in step width at the walk–run transition. In the modern bipeds, these patterns reflect the use of either a discontinuous locomotor repertoire, characterized by distinct gaits (humans), or a continuous locomotor repertoire, where walking smoothly transitions into running (birds). The non-avian theropods are consequently inferred to have had a continuous locomotor repertoire, possibly including grounded running. Thus, features that characterize avian terrestrial locomotion had begun to evolve early in theropod history

A Deep VLA survey at 6 cm in the Lockman Hole

This is the published version, also available here: http://dx.doi.org/10.1051/0004-6361:20021721.We have obtained a deep radio image with the Very Large Array at 6 cm in the Lockman Hole. The noise level in the central part of the field is ~ $11~\mu$Jy. From these data we have extracted a catalogue of 63 radio sources with a maximum distance of 10 arcmin from the field center and with peak flux density greater than 4.5 times the local rms noise. The differential source counts are in good agreement with those obtained by other surveys. The analysis of the radio spectral index suggests a flattening of the average radio spectra and an increase of the population of flat spectrum radio sources in the faintest flux bin. Cross correlation with the ROSAT/XMM X-ray sources list yields 13 reliable radio/X-ray associations, corresponding to ~21% of the radio sample. Most of these associations (8 out of 13) are classified as type II AGN. Using optical CCD ( V and I) and $K^{\prime}$ band data with approximate limits of $V\sim25.5$ mag, $I\sim 24.5$ mag and $K^{\prime}\sim20.2$ mag, we found an optical identification for 58 of the 63 radio sources. This corresponds to an identification rate of ~92%, one of the highest percentages so far available. From the analysis of the colour-colour diagram and of the radio flux - optical magnitude diagram we have been able to select a subsample of radio sources whose optical counterparts are likely to be high redshift ( z>0.5) early-type galaxies, hosting an Active Galactic Nucleus responsible of the radio activity. This class of objects, rather than a population of star-forming galaxies, appears to be the dominant population ( $\gtrsim$50%) in a 5 GHz selected sample with a flux limit as low as 50 $\mu$Jy. We also find evidence that at these faint radio limits a large fraction (~60%) of the faintest optical counterparts (i.e. sources in the magnitude range 22.54$ and combining our radio data with existing ISO data we conclude that these EROs sources are probably associated with high redshift, passively evolving elliptical galaxies. The six radio selected EROs represent only ~2% of the optically selected EROs present in the field. If their luminosity is indeed a sign of AGN activity, the small number of radio detections suggests that a small fraction of the EROS population contains an active nucleus

Partial sex linkage and linkage disequilibrium on the guppy sex chromosome

The guppy Y chromosome has been considered a model system for the evolution of suppressed recombination between sex chromosomes, and it has been proposed that complete sex‐linkage has evolved across about 3 Mb surrounding this fish's sex‐determining locus, followed by recombination suppression across a further 7 Mb of the 23 Mb XY pair, forming younger “evolutionary strata”. Sequences of the guppy genome show that Y is very similar to the X chromosome. Knowing which parts of the Y are completely nonrecombining, and whether there is indeed a large completely nonrecombining region, are important for understanding its evolution. Here, we describe analyses of PoolSeq data in samples from within multiple natural populations from Trinidad, yielding new results that support previous evidence for occasional recombination between the guppy Y and X. We detected recent demographic changes, notably that downstream populations have higher synonymous site diversity than upstream ones and other expected signals of bottlenecks. We detected evidence of associations between sequence variants and the sex‐determining locus, rather than divergence under a complete lack of recombination. Although recombination is infrequent, it is frequent enough that associations with SNPs can suggest the region in which the sex‐determining locus must be located. Diversity is elevated across a physically large region of the sex chromosome, conforming to predictions for a genome region with infrequent recombination that carries one or more sexually antagonistic polymorphisms. However, no consistently male‐specific variants were found, supporting the suggestion that any completely sex‐linked region may be very small

Лечение и профилактика гриппа с использованием биофлавоноидов

На основании аналитического обзора литературы представлены данные об эффективности и безопасности применения биофлавоноидов (лекарственный препарат Протефлазид в виде капель и сироп Иммунофлазид) в схеме лечения и профилактики гриппа. Проанализированные в этой работе научные публикации свидетельствуют об этиологически и патогенетически обоснованном назначении Протефлазида, механизм противогриппозного действия которого основан на угнетении репродукции вирусов гриппа, в том числе пандемического штама A/FM/1/47/H1N1/ за счет механизма ингибирования нейраминидазной активности, индукции синтеза интерферона

The “Spirit of New Orleans” : translating a model of intervention with maltreated children and their families for the Glasgow context

Peer reviewedPreprin

Assessing wellbeing at school entry using the strengths and difficulties questionnaire: professional perspectives

&lt;p&gt;Background: Emotional and behavioural disorders in early childhood are related to poorer academic attainment and school engagement, and difficulties already evident at the point of starting school can affect a child’s later social and academic development. Successful transfer from pre-school settings to primary education is helped by communication between pre-school staff and primary school teachers. Typically, in Scotland, pre-school establishments prepare individual profiles of children before they start school around the age of five years, highlighting their strengths and development needs, for transfer to primary schools. There is, however, no consistent approach to the identification of potential social, emotional and behavioural problems. In 2010, in one local authority area in Scotland, the Strengths and Difficulties Questionnaire (SDQ) was introduced for children about to start school as a routine, structured, component of the transition process to help teachers plan support arrangements for classes and individual children. The SDQ assesses emotional, conduct, hyperactivity/ inattention and peer-relationship problems as well as pro-social behaviour. In order to be an effective means of communicating social and emotional functioning, the use of instruments such as the SDQ needs to be practicable. Finding out the views of pre-school education staff with experience of assessing children using the SDQ was, therefore, essential to establish its future utility.&lt;/p&gt; &lt;p&gt;Aim: The purpose of this study was to explore the views of pre-school education staff about assessing social and emotional wellbeing of children at school entry using the SDQ. The objectives were to examine the opinions of pre-school workers about completing the SDQ and to elicit their thoughts on the value of doing this and their perceptions of the usefulness of the information collected.&lt;/p&gt; &lt;p&gt;Method: Pre-school establishments were approached using a purposive sampling strategy in order to achieve a mix of local authority (n=14) and ‘partnership’ establishments (n=8) as well as different socio-economic areas. Semi-structured interviews (n=25) were conducted with pre-school head teachers (n=14) and child development officers (n=11) in order to explore the process of completing the SDQ along with perceptions of its value. The interviews were transcribed verbatim and analysed thematically.&lt;/p&gt; &lt;p&gt;Results: In general, staff in pre-school establishments viewed the use of the SDQ positively. It was seen as a chance to highlight the social and emotional development of children rather than just their academic or educational ability. Most felt that the SDQ had not identified anything they did not already know about a child. A minority, nevertheless, suggested that a previously unrecognised potential difficulty was brought to light, most commonly emotional problems. Completing the SDQ was felt to be relatively straightforward even though the staff felt under pressure from competing priorities. Concerns were, however, raised about the potential of labelling a child at an early stage of formal education.&lt;/p&gt; &lt;p&gt;Conclusion: The findings from this small scale study suggest that, from the point of view of pre-school education staff, it is feasible to assess children systematically for social and behavioural problems as part of the routine transition process at school entry.&lt;/p&gt