Particle acceleration by twisted laser beams

We consider particle acceleration in plasmas, using twisted laser beams, or beams with orbital angular momentum. We discuss different acceleration processes using two LG laser modes, which include donut wakefield, beat-wave and self-torque acceleration, and compare the respective properties. We show that a self-torque configuration is able to produce azimuthal acceleration and can therefore be considered as an alternative method to produce helical electron beams

Evoking imaginaries : Art probing, ethnography and more-than-academic practice

I discuss and argue for combinations of artistic practice and cultural analysis, for meta- disciplinary and serendipitous endeavours that can entangle art and ethnographic research. These combinations can be understood as practices that are more-than-academic. I define the artistic side of this combinatory work as art probing. Art probes have a double function. First, they can instil inspiration and be possible points of departure for research, and, second, they can be used to communicate scientific concepts and arguments beyond the scope of academic worlds. According to this point of view, artistic and scientific output should be seen as provisional renditions oriented towards different audiences and as part of an extended open-ended art of inquiry. When working with this more-than-academic practice, a number of stakeholders are involved, ranging from academic professionals to art institutions, museums and visitors of art exhibitions, and performances. I will discuss how I understand ethnography as part of this process and in relation to practices of art probing

The role of CAV3 in long QT : clinical and functional assessment of a caveolin-3/Kc11.1 compound heterozygote

CITATION: Hedley, P. L. et al. 2013. The role of CAV3 in long QT : clinical and functional assessment of a caveolin-3/Kc11.1 compound heterozygote. Circulation: Cardiovascular Genetics, 6:452-461, doi:10.1161/CIRCGENETICS.113.000137.The original publication is available at https://www.ahajournals.orgBackground— Mutations in CAV3, coding for caveolin-3, the major constituent scaffolding protein of cardiac caveolae, have been associated with skeletal muscle disease, cardiomyopathy, and most recently long–QT syndrome (LQTS) and sudden infant death syndrome. We examined the occurrence of CAV3 mutations in a large cohort of patients with LQTS. Methods and Results— Probands with LQTS (n=167) were screened for mutations in CAV3 using direct DNA sequencing. A single proband (0.6%) was found to be a heterozygous carrier of a previously described missense mutation, caveolin-3:p.T78M. The proband was also a heterozygous carrier of the trafficking-deficient Kv11.1:p.I400N mutation. The caveolin-3:p.T78M mutation was found isolated in 3 family members, none of whom had a prolonged QTc interval. Coimmunoprecipitations of caveolin-3 and the voltage-gated potassium channel subunit (Kv11.1) were performed, and the electrophysiological classification of the Kv11.1 mutant was carried out by patch-clamp technique in human embryonic kidney 293 cells. Furthermore, the T-wave morphology was assessed in mutation carriers, double mutation carriers, and nonmutation carriers by applying a morphology combination score. The morphology combination score was normal for isolated caveolin-3:p.T78M carriers and of LQT2 type in double heterozygotes. Conclusions— Mutations in CAV3 are rare in LQTS. Furthermore, caveolin-3:p.T78M did not exhibit a LQTS phenotype. Because no association has ever been found between LQTS and isolated CAV3 mutations, we suggest that LQTS9 is considered a provisional entity.https://www.ahajournals.org/doi/10.1161/CIRCGENETICS.113.000137Publisher's versio