5,999 research outputs found
Deterministic dense coding and entanglement entropy
We present an analytical study of the standard two-party deterministic
dense-coding protocol, under which communication of perfectly distinguishable
messages takes place via a qudit from a pair of non-maximally entangled qudits
in pure state |S>. Our results include the following: (i) We prove that it is
possible for a state |S> with lower entanglement entropy to support the sending
of a greater number of perfectly distinguishable messages than one with higher
entanglement entropy, confirming a result suggested via numerical analysis in
Mozes et al. [Phys. Rev. A 71 012311 (2005)]. (ii) By explicit construction of
families of local unitary operators, we verify, for dimensions d = 3 and d=4, a
conjecture of Mozes et al. about the minimum entanglement entropy that supports
the sending of d + j messages, j = 2, ..., d-1; moreover, we show that the j=2
and j= d-1 cases of the conjecture are valid in all dimensions. (iii) Given
that |S> allows the sending of K messages and has the square roof of c as its
largest Schmidt coefficient, we show that the inequality c <= d/K, established
by Wu et al. [ Phys. Rev. A 73, 042311 (2006)], must actually take the form c <
d/K if K = d+1, while our constructions of local unitaries show that equality
can be realized if K = d+2 or K = 2d-1.Comment: 19 pages, 2 figures. Published versio
Temporal Evolution of Financial Market Correlations
We investigate financial market correlations using random matrix theory and
principal component analysis. We use random matrix theory to demonstrate that
correlation matrices of asset price changes contain structure that is
incompatible with uncorrelated random price changes. We then identify the
principal components of these correlation matrices and demonstrate that a small
number of components accounts for a large proportion of the variability of the
markets that we consider. We then characterize the time-evolving relationships
between the different assets by investigating the correlations between the
asset price time series and principal components. Using this approach, we
uncover notable changes that occurred in financial markets and identify the
assets that were significantly affected by these changes. We show in particular
that there was an increase in the strength of the relationships between several
different markets following the 2007--2008 credit and liquidity crisis.Comment: 15 pages, 10 figures, 1 table. Accepted for publication in Phys. Rev.
E. v2 includes additional section
Dynamic communities in multichannel data: An application to the foreign exchange market during the 2007--2008 credit crisis
We study the cluster dynamics of multichannel (multivariate) time series by
representing their correlations as time-dependent networks and investigating
the evolution of network communities. We employ a node-centric approach that
allows us to track the effects of the community evolution on the functional
roles of individual nodes without having to track entire communities. As an
example, we consider a foreign exchange market network in which each node
represents an exchange rate and each edge represents a time-dependent
correlation between the rates. We study the period 2005-2008, which includes
the recent credit and liquidity crisis. Using dynamical community detection, we
find that exchange rates that are strongly attached to their community are
persistently grouped with the same set of rates, whereas exchange rates that
are important for the transfer of information tend to be positioned on the
edges of communities. Our analysis successfully uncovers major trading changes
that occurred in the market during the credit crisis.Comment: 8 pages, 6 figures, accepted for publication in Chao
Detecting a Currency's Dominance or Dependence using Foreign Exchange Network Trees
In a system containing a large number of interacting stochastic processes,
there will typically be many non-zero correlation coefficients. This makes it
difficult to either visualize the system's inter-dependencies, or identify its
dominant elements. Such a situation arises in Foreign Exchange (FX) which is
the world's biggest market. Here we develop a network analysis of these
correlations using Minimum Spanning Trees (MSTs). We show that not only do the
MSTs provide a meaningful representation of the global FX dynamics, but they
also enable one to determine momentarily dominant and dependent currencies. We
find that information about a country's geographical ties emerges from the raw
exchange-rate data. Most importantly from a trading perspective, we discuss how
to infer which currencies are `in play' during a particular period of time
Recommended from our members
Service user and eating disorder therapist views on anorexia nervosa recovery criteria
Objectives: Recovery from anorexia nervosa (AN) is difficult to define, and efforts to establish recovery criteria have led to several versions being proposed. Using the perspectives of people with histories of AN and therapists working in the field, we sought to explore the face validity of Khalsa et al (2017) as one of the most recent examples of proposed systematic recovery criteria.
Design: We interviewed 11 health service users (SUs) with histories of AN who had previously received treatment alongside 8 eating disorder therapists (EDTs), exploring their views on the proposed AN recovery criteria.
Methods: Data from verbal and written interviews were analysed thematically. Separate thematic analyses of SU and EDT interviews highlighted where concerns converged and diverged across participants.
Results: Both groups saw some merits of having universally recognized recovery criteria, and the multidimensional approach was welcomed, but EDTs were uncomfortable with considering their use in therapy and SUs felt key components were missing around emotional coping and life quality. SUs disliked the prominence of body mass index (BMI) in the criteria, and all struggled with the proposed duration for recovery. Conceptually, the notion of recovery as an endpoint rather than a journey was contested.
Conclusions: Our findings indicate disparities between academically derived recovery criteria and lived experiences and indicate perceived challenges in using such criteria in therapeutic settings. Including SUs and EDTs in the development of criteria may improve the likelihood of consolidating AN recovery criteria, but conceptual challenges remain
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Gut microbiome composition in the Hispanic Community Health Study/Study of Latinos is shaped by geographic relocation, environmental factors, and obesity.
Background: Hispanics living in the USA may have unrecognized potential birthplace and lifestyle influences on the gut microbiome. We report a cross-sectional analysis of 1674 participants from four centers of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), aged 18 to 74 years old at recruitment.Results: Amplicon sequencing of 16S rRNA gene V4 and fungal ITS1 fragments from self-collected stool samples indicate that the host microbiome is determined by sociodemographic and migration-related variables. Those who relocate from Latin America to the USA at an early age have reductions in Prevotella to Bacteroides ratios that persist across the life course. Shannon index of alpha diversity in fungi and bacteria is low in those who relocate to the USA in early life. In contrast, those who relocate to the USA during adulthood, over 45 years old, have high bacterial and fungal diversity and high Prevotella to Bacteroides ratios, compared to USA-born and childhood arrivals. Low bacterial diversity is associated in turn with obesity. Contrasting with prior studies, our study of the Latino population shows increasing Prevotella to Bacteroides ratio with greater obesity. Taxa within Acidaminococcus, Megasphaera, Ruminococcaceae, Coriobacteriaceae, Clostridiales, Christensenellaceae, YS2 (Cyanobacteria), and Victivallaceae are significantly associated with both obesity and earlier exposure to the USA, while Oscillospira and Anaerotruncus show paradoxical associations with both obesity and late-life introduction to the USA.Conclusions: Our analysis of the gut microbiome of Latinos demonstrates unique features that might be responsible for health disparities affecting Hispanics living in the USA
MLH1 deficiency leads to deregulated mitochondrial metabolism
The DNA mismatch repair (MMR) pathway is responsible for the repair of base–base mismatches and insertion/deletion loops that arise during DNA replication. MMR deficiency is currently estimated to be present in 15–17% of colorectal cancer cases and 30% of endometrial cancers. MLH1 is one of the key proteins involved in the MMR pathway. Inhibition of a number of mitochondrial genes, including POLG and PINK1 can induce synthetic lethality in MLH1-deficient cells. Here we demonstrate for the first time that loss of MLH1 is associated with a deregulated mitochondrial metabolism, with reduced basal oxygen consumption rate and reduced spare respiratory capacity. Furthermore, MLH1-deficient cells display a significant reduction in activity of the respiratory chain Complex I. As a functional consequence of this perturbed mitochondrial metabolism, MLH1-deficient cells have a reduced anti-oxidant response and show increased sensitivity to reactive oxidative species (ROS)-inducing drugs. Taken together, our results provide evidence for an intrinsic mitochondrial dysfunction in MLH1-deficient cells and a requirement for MLH1 in the regulation of mitochondrial function
Dysglycemia and a History of Reproductive Risk Factors
OBJECTIVE—The purpose of this study was to identify reproductive risk factors associated with dysglycemia (diabetes, impaired glucose tolerance, and impaired fasting glucose) in a contemporary multiethnic population
A broad distribution of the alternative oxidase in microsporidian parasites
Microsporidia are a group of obligate intracellular parasitic eukaryotes that were considered to be amitochondriate until the recent discovery of highly reduced mitochondrial organelles called mitosomes. Analysis of the complete genome of Encephalitozoon cuniculi revealed a highly reduced set of proteins in the organelle, mostly related to the assembly of ironsulphur clusters. Oxidative phosphorylation and the Krebs cycle proteins were absent, in keeping with the notion that the microsporidia and their mitosomes are anaerobic, as is the case for other mitosome bearing eukaryotes, such as Giardia. Here we provide evidence opening the possibility that mitosomes in a number of microsporidian lineages are not completely anaerobic. Specifically, we have identified and characterized a gene encoding the alternative oxidase (AOX), a typically mitochondrial terminal oxidase in eukaryotes, in the genomes of several distantly related microsporidian species, even though this gene is absent from the complete genome of E. cuniculi. In order to confirm that these genes encode functional proteins, AOX genes from both A. locustae and T. hominis were over-expressed in E. coli and AOX activity measured spectrophotometrically using ubiquinol-1 (UQ-1) as substrate. Both A. locustae and T. hominis AOX proteins reduced UQ-1 in a cyanide and antimycin-resistant manner that was sensitive to ascofuranone, a potent inhibitor of the trypanosomal AOX. The physiological role of AOX microsporidia may be to reoxidise reducing equivalents produced by glycolysis, in a manner comparable to that observed in trypanosome
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