6,656 research outputs found

    Non-Market Valuation of Open Space and Other Amenities Associated with Retention of Lands in Agricultural Use

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    The most productive farmland in southcentral Alaska is currently under intense development pressure due to rapid population increases and consequential increases in demand for suburban housing. This study utilizes a contingent valuation iterative bidding game to estimate the willingness of Matanuska-Susitna Borough residents to pay to preserve open space and other historical/environmental amenities associated with farming activities. Determinants of consumer behavior are addressed as well as total benefits and costs of various posited development scenarios. This information may be useful to policymakers assessing actions designed to purchase development rights from Matanuska-Susitna farmers

    Filarial Genomics

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    SURVEYING FOR RANAVIRUS IN GREEN FROGS (LITHOBATES CLAMITANS) AT FIVE LOCATIONS IN INDIANA

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    Ranaviruses are an emerging pathogen within the United States that infects amphibians, reptiles, and fish. A Frog Virus 3-like (FV3) ranavirus has been detected at only two locations in Indiana; however, there have been few attempts to broadly sample for ranaviruses to determine their distribution across the state. This knowledge is necessary for the continued management and conservation of native amphibian populations. Our objective was to assess the occurrence of FV3-like ranaviruses in larval Green Frog (Lithobates clamitans) populations at five sites located in different regions of Indiana. Tissue samples were collected from 166 individuals and were assayed using both conventional and qPCR methods. We did not detect the presence of any FV3-like ranaviruses at any of the five sites with either PCR method, suggesting the possibility that at these sites, FV3-like ranaviruses may not be present. However, continued sampling should be carried out to monitor the status of the presence of ranaviruses in this portion of the Midwest

    GLObal Backscatter Experiment (GLOBE) Pacific survey mission

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    NASA conducted the GLObal Backscatter Experiment (GLOBE) Survey Mission over the near coastal and remote Pacific Ocean during 6 to 30 Nov. 1989 (GLOBE 1) and 13 May to 5 Jun. 1990 (GLOBE 2). These missions studied the optical, physical, and chemical properties of atmospheric aerosols. Particular emphasis was given to the magnitude and spatial variability of aerosol backscatter coefficients at mid-infrared wavelengths, and to the remote middle and upper troposphere, where these aerosol properties are poorly understood. Survey instruments were selected to provide either direct beta measurements at the key wavelengths, empirical links with long term or global scale aerosol climatologies, or aerosol microphysics data required to model any of these quantities. The survey deployment included both long distance 6 to 8 hour transit flights and detailed 4 to 6 hour local flights. Several general features were observed from preliminary Survey data analyses. Validation and intercomparison results have shown good agreement, usually better than a factor of two. Atmospheric aerosols frequently exhibited a three layer vertical structure, with (1) high and fairly uniform backscatter in the shallow cloud capped marine boundary layer; (2) moderate and highly variable backscatter in a deeper overlaying cloud pumped layer; and (3) low, regionally uniform, but seasonally and latitudinally variable backscatter in the middle and upper troposphere. The survey missions represent two isolated snapshots of a small portion of the global aerosol system. Consequently, Survey results can best be understood by synthesizing them with the more comprehensive GLOBE data base, which is being compiled at NASA-Marshall

    On the Permanence of Racial Injustice and the Possibility of Deracialization

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    Deracialization and Democracy

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    The United States suffers the conthiued costs of mahitainhig a racial hierarchy. Enhanced diversity and growhig realization of the economic costs of that hierarchy could lead to democratic pressure for reform. Yet, in the U.S., elites on the radical right seek to entrench themselves in power through the constriction of voting power and the strategic use of the racial hierarchy as a political tool. This Article traces the anti-democratic efforts of the radical right to limit the political power of the nation\u27s enhanced diversity, and to utilize archaic governance measures to entrench themselves politically, regardless of the costs of allowing the racial hierarchy to continue to fester. Antidemocratic efforts to limit voting power to assure non-democratic governance and outcomes recently scored significant success as recounted in this Article. The anti-democratic contrivances to limit the power of enhanced diversity requires comparable countermeasures to vindicate the core value of expanded democracy that find its roots in our history and in the Constitution\u27s trajectory towards ever greater democratic governance. This Article surveys countermeasures that could lead to the preservation and even expansion of democratic governance. It concludes that only through a renewed pursuit of expansive voting rights can we restore our democracy and move the nation away from its racist past

    SDSS J142625.71+575218.3: A Prototype for A New Class of Variable White Dwarf

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    We present the results of a search for pulsations in six of the recently discovered carbon-atmosphere white dwarf ("hot DQ") stars. On the basis of our theoretical calculations, the star SDSS J142625.71 + 575218.3 is the only object expected to pulsate. We observe this star to be variable, with significant power at 417.7 s and 208.8 s ( first harmonic), making it a strong candidate as the first member of a new class of pulsating white dwarf stars, the DQVs. Its folded pulse shape, however, is quite different from that of other white dwarf variables and shows similarities with that of the cataclysmic variable AM CVn, raising the possibility that this star may be a carbon-transferring analog of AM CVn stars. In either case, these observations represent the discovery of a new and exciting class of object.NSF AST-0507639, AST-0602288, AST-0607480, AST-0307321Astronom

    Molecular Phylogenetic Studies on Filarial Parasites Based on 5S Ribosomal Spacer Sequences

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    This paper is the first large-scale molecular phylogenetic study on filarial parasites (family Onchocercidae) which includes 16 spe­ cies of 6 genera : Brugia beaveri Ash et Little, 1964 ; B. buckleyiDissanaike et Paramananthan, 1961 ; B. malayi (Brug, 1927) Buckley, 1960; B. pahangi (Buckley et Edeson, 1956) Buckley, 1960; B. patei (Buckley, Nelson et Heisch, 1958) Buckley, 1960; B. timori Partono etal, 1977; Wuchereria bancrofti(Cobbold, 1877) Seurat, 1921; W. kalimantani Palmieri , Purnomo, Dennis and Marwoto, 1980; Mansonella perstans(Manson, 1891 ) Eberhard et Orihel, 1 9 8 4 ; Loa loa, Stiles, 1905; Onchocerca volvulus (Leuckart, 1983) Railliet et Henry, 1910; O. ochengi Bwangamoi, 1969; O. gutturosa Neumann, 1910; Dirofilaria immitis (Leidy, 1856) Railliet et Henry, 1911 ; Acanthocheilonema viteae (Krepkogorskaya, 1933) Bain, Baker et Chabaud, 1982 and Litomosoides sigmodontis Chandler, 1931. 5S rRNA gene spacer region sequence data were collec­ ted by PCR, cloning and dideoxy sequencing. The 5S rRNA gene spacer region sequences were aligned and analyzed by maxi­ mum parsimony algorithms, distance methods and maximum likeli­ hood methods to construct phylogenetic trees. Bootstrap analysis was used to test the robustness of the different phylogenetic reconstructions. The data indicated that 5S spacer region sequences are highly conserved within species yet differ signifi­ cantly between species. Spliced leader sequences were observed in all of the 5S rDNA spacers with no sequence variation, although flanking region sequence and length heterogeneity was observed even within species. All of the various tree-building methods gave very similar results. This study identified four clades which are strongly supported by bootstrap analysis: the Brugiaclade; the Wuchereria clade; the Brugia-Wuchereria clade and the Onchocerca clade. The analyses indicated that L. sigmodontisand A. viteae may be the most primitive among the 16 species studied. The data did not show any close relationship betweenLoa loa and D. immitis presently classified in the same subfamily, and the constitution of the Dirofilariinae subfamily is questionable

    Targeting lymphatic vessel functions through tyrosine kinases

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    The lymphatic vascular system is actively involved in tissue fluid homeostasis, immune surveillance and fatty acid transport. Pathological conditions can arise from injury to the lymphatics, or they can be recruited in the context of cancer to facilitate metastasis. Protein tyrosine kinases are central players in signal transduction networks and regulation of cell behavior. In the lymphatic endothelium, tyrosine kinases are involved in processes such as the maintenance of existing lymphatic vessels, growth and maturation of new vessels and modulation of their identity and function. As such, they are attractive targets for both existing inhibitors and the development of new inhibitors which affect lymphangiogenesis in pathological states such as cancer. RNAi screening provides an opportunity to identify the functional role of tyrosine kinases in the lymphatics. This review will discuss the role of tyrosine kinases in lymphatic biology and the potential use of inhibitors for anti-lymphangiogenic therapy
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