Encoding of low-quality DNA profiles as genotype probability matrices for improved profile comparisons, relatedness evaluation and database searches

Many DNA profiles recovered from crime scene samples are of a quality that does not allow them to be searched against, nor entered into, databases. We propose a method for the comparison of profiles arising from two DNA samples, one or both of which can have multiple donors and be affected by low DNA template or degraded DNA. We compute likelihood ratios to evaluate the hypothesis that the two samples have a common DNA donor, and hypotheses specifying the relatedness of two donors. Our method uses a probability distribution for the genotype of the donor of interest in each sample. This distribution can be obtained from a statistical model, or we can exploit the ability of trained human experts to assess genotype probabilities, thus extracting much information that would be discarded by standard interpretation rules. Our method is compatible with established methods in simple settings, but is more widely applicable and can make better use of information than many current methods for the analysis of mixed-source, low-template DNA profiles. It can accommodate uncertainty arising from relatedness instead of or in addition to uncertainty arising from noisy genotyping. We describe a computer program GPMDNA, available under an open source license, to calculate LRs using the method presented in this paper.Comment: 28 pages. Accepted for publication 2-Sep-2016 - Forensic Science International: Genetic

Older people, regeneration and health and well-being. Case study of Salford Partnership Board for Older People

This study sat within a national project aimed at demonstrating that expert knowledge housed within universities can make a positive impact in urban communities around four themes: Community Cohesion, Crime, Enterprise and Health & Wellbeing. It involved the Universities of Salford, Northumbria, Central Lancashire, Manchester Metropolitan University and Bradford. The project aimed to address key urban regeneration challenges in the North of England through inter-disciplinary collaboration between partner universities and practitioner organisations. It also sought to build a long term strategic alliance between core university partners. Within each of the four project areas there were a number of smaller projects each focusing on the relationship between the theme and urban regeneration. This study sought to establish how partnership boards for older people address the health and well being needs of people over 50 years of age including how health and wellbeing are defined; strategies older people adopt to change service providers' actions; learning by service providers about the involvement of older people on Boards; and how this influences practice. The main activity within this study was to interview Salford Partnership Board members. The findings informed further development of the Board

Are You Talking to Me? How Ideological and Gender Characteristics Moderate the Effect of Legitimizing Rhetoric on SCOTUS Legitimacy

Possessing neither purse nor sword, the unelected US Supreme Court relies on sustained public confidence in its institutional credibility to give force to its decisions. Previous research shows that Supreme Court justices are increasingly making public appearances to engage in a course of institutional maintenance to preserve its legitimacy. Amid a potential legitimacy crisis, justices seek to shore up the Court’s public support in these public appearances by emphasizing the apolitical nature of the Court and its decision making. The question for a growing body of literature is whether these attempts at institutional maintenance do, in fact, lead to higher support for the Court. Using an original survey experiment where we manipulate the identity of the justice giving legitimizing rhetoric, we find that respondents’ ideological preferences and female respondents’ level of gender identity do impact the effectiveness of such rhetoric. These results build on previous work by demonstrating the importance of justice identity in conditioning how different ideologues respond to the Court’s elite signals

Is There Evidence that Legislative Ambition Matches Development? Evaluating the Factors Influencing Wind Energy Development

Resource /Energy Economics and Policy,

Co-evolution of Calcium Homeostasis and Lactase Persistence: Implications for Treatment of Degenerative Bone Diseases in the 21st Century

Recent research on the relationship between osteoporosis and lactase persistence has revealed that these two factors are positively correlated. There is existing evidence that shows the domestication of cattle was a selective force for the lactase persistence allele. We hypothesize that this genetic change caused a shift in the ancestral physiological mechanism for calcium homeostasis, resulting in a derived calcium homeostasis. Consequently, individuals with this derived calcium homeostasis are more susceptible to degenerative bone diseases, such as osteoporosis. Osteoporosis is a topic of major health concern in the United States, considering that it is responsible for more hospital stays for women aged 45 or older than any other disease in America. Geriatric populations are the demographic most heavily affected by osteoporosis—particularly postmenopausal women. Research has also indicated that roughly 20 percent of elderly patients die within the first year of a hip fracture and less than 50 percent return to their previous lifestyle. The health concerns associated with osteoporosis along with the expensive costs of treatment place a priority on alternative ways to treat and prevent this disease. We review the development of lactase persistence along with important biological molecules involved in calcium homeostasis. We also discuss the physiology behind the ancestral calcium homeostasis and the derived calcium homeostasis, as well as potential paths for further research

2014 Fed Challenge Script: Current State of the Economy

Good afternoon everyone and thank you for having us here today. Though the recession began in 2007 and officially ended in 2009, recovery has been painfully slow. GDP growth has been insufficient to close the output gap, there continues to be slack in the labor market and inflation has stabilized below the Federal Reserve percent target. We are not meeting our dual mandate of full employment and stable prices even 6 years after the end of the recession. Despite some signs of strengthening in the economy during the past year, we do not believe that economy is on a self-sustaining path of recovery. Furthermore, the monetary policy actions taken by the Fed thus far to pull us out of the Great Recession have been insufficient. We propose a substantial strengthening of the our forward guidance; specifically, a commitment not to raise the federal funds rate until nominal GDP has returned to a path that we consider consistent with the dual mandate. [excerpt

Implementation of an Autonomous Multi-Maneuver Targeting Sequence for Lunar Trans-Earth Injection

Using a fully analytic initial guess estimate as a first iterate, a targeting procedure that constructs a flyable burn maneuver sequence to transfer a spacecraft from any closed Moon orbit to a desired Earth entry state is developed and implemented. The algorithm is built to support the need for an anytime abort capability for Orion. Based on project requirements, the Orion spacecraft must be able to autonomously calculate the translational maneuver targets for an entire Lunar mission. Translational maneuver target sequences for the Orion spacecraft include Lunar Orbit Insertion (LOI), Trans-Earth Injection (TEI), and Trajectory Correction Maneuvers (TCMs). This onboard capability is generally assumed to be supplemental to redundant ground computation in nominal mission operations and considered as a viable alternative primarily in loss of communications contingencies. Of these maneuvers, the ability to accurately and consistently establish a flyable 3-burn TEI target sequence is especially critical. The TEI is the sole means by which the crew can successfully return from the Moon to a narrowly banded Earth Entry Interface (EI) state. This is made even more critical by the desire for global access on the lunar surface. Currently, the designed propellant load is based on fully optimized TEI solutions for the worst case geometries associated with the accepted range of epochs and landing sites. This presents two challenges for an autonomous algorithm: in addition to being feasible, the targets must include burn sequences that do not exceed the anticipated propellant load