Do Dispersing Monkeys Follow Kin? Evidence from Gray-cheeked Mangabeys (Lophocebus albigena)

Among social vertebrates, immigrants may incur a substantial fitness cost when they attempt to join a new group. Dispersers could reduce that cost, or increase their probability of mating via coalition formation, by immigrating into groups containing first- or second-degree relatives. We here examine whether dispersing males tend to move into groups containing fathers or brothers in gray-cheeked mangabeys (Lophocebus albigena) in Kibale National Park, Uganda. We sampled blood from 21 subadult and adult male mangabeys in 7 social groups and genotyped them at 17 microsatellite loci. Twelve genotyped males dispersed to groups containing other genotyped adult males during the study; in only 1 case did the group contain a probable male relative. Contrary to the prediction that dispersing males would follow kin, relatively few adult male dyads were likely first- or second-degree relatives; opportunities for kin-biased dispersal by mangabeys appear to be rare. During 4 yr of observation, adult brothers shared a group only once, and for only 6 wk. Mean relatedness among adult males sharing a group was lower than that among males in different groups. Randomization tests indicate that closely related males share groups no more often than expected by chance, although these tests had limited power. We suggest that the demographic conditions that allow kin-biased dispersal to evolve do not occur in mangabeys, may be unusual among primates, and are worth further attention

The UV continuum slopes of early star-forming galaxies in JADES

© 2024 The Author(s). Published by Oxford University Press on behalf of Royal Astronomical Society. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY), https://creativecommons.org/licenses/by/4.0/The power-law slope of the rest-ultraviolet (UV) continuum (fλ ∝ λβ) is a key metric of early star-forming galaxies, providing one of our only windows into the stellar populations and physical conditions of z ≳ 10 galaxies. Expanding upon previous studies with limited sample sizes, we leverage deep imaging from the JWST Advanced Deep Extragalactic Survey (JADES) to investigate the UV slopes of 179 z ≳ 9 galaxies with apparent magnitudes of mF200W ≃ 26–31, which display a median UV slope of β = −2.4. We compare to a statistical sample of z ≃ 5–9 galaxies, finding a shift towards bluer rest-UV colours at all $M_{\rm UV}$. The most UV-luminous z ≳ 9 galaxies are significantly bluer than their lower redshift counterparts, representing a dearth of moderately red galaxies within the first 500 Myr. At yet earlier times, the z ≳ 11 galaxy population exhibits very blue UV slopes, implying very low impact from dust attenuation. We identify a robust sample of 44 galaxies with β ≲ −2.8, which have spectral energy distributions requiring models of density-bounded H ii regions and median ionizing photon escape fractions of 0.51 to reproduce. Their rest-optical colours imply that this sample has weaker emission lines (median mF356W − mF444W = 0.19 mag) than typical galaxies (median mF356W − mF444W = 0.39 mag), consistent with the inferred escape fractions. This sample consists of relatively low stellar masses (median $\log (M/{\rm M}_{\odot })=7.5\pm 0.2$), and specific star formation rates (sSFRs; median $=79 \, \rm Gyr^{-1}$) nearly twice that of our full galaxy sample (median sSFRs $=44 \, \rm Gyr^{-1}$), suggesting these objects are more common among systems experiencing a recent upturn in star formation. We demonstrate that the shutoff of star formation provides an alternative solution for modelling of extremely blue UV colours, making distinct predictions for the rest-optical emission of these galaxies. Future spectroscopy will be required to distinguish between these physical pictures.Peer reviewe

The UV Continuum Slopes of Early Star-Forming Galaxies in JADES

The power-law slope of the rest-UV continuum ($f_{\lambda}\propto\lambda^{\beta}$) is a key metric of early star forming galaxies, providing one of our only windows into the stellar populations and physical conditions of $z>10$ galaxies. Expanding upon previous studies with limited sample sizes, we leverage deep imaging from JADES to investigate the UV slopes of 179 $z>9$ galaxies with apparent magnitudes of $m_{\rm F200W}=26-31$, which display a median UV slope of $\beta=-2.4$. We compare to a statistical sample of $z=5-9$ galaxies, finding a shift toward bluer rest-UV colors at all $\rm~M_{UV}$. The most UV-luminous $z>9$ galaxies are significantly bluer than their lower-redshift counterparts, representing a dearth of moderately-red galaxies in the first $500~$Myr. At yet earlier times, the $z>11$ galaxy population exhibits very blue UV slopes, implying very low attenuation from dust. We identify a robust sample of 44 galaxies with $\beta<-2.8$, which have SEDs requiring models of density-bounded HII regions and median ionizing photon escape fractions of $0.51$ to reproduce. Their rest-optical colors imply that this sample has weaker emission lines (median $m_{\rm F356W}-m_{\rm F444W}=0.19$ mag) than typical galaxies (median $m_{\rm F356W}-m_{\rm F444W}=0.39$ mag), consistent with the inferred escape fractions. This sample has relatively low stellar masses (median $\log(M/M_{\odot})=7.5$), and specific star-formation rates (median$=79\rm/Gyr$) nearly twice that of our full sample (median$=44\rm/Gyr$), suggesting they are more common among systems experiencing a recent upturn in star formation. We demonstrate that the shutoff of star formation provides an alternative solution for modelling of extremely blue UV colors, making distinct predictions for the rest-optical emission of these galaxies. Future spectroscopy will be required to distinguish between these physical pictures.Comment: 17 pages, 13 figures; submitted to MNRA

Early Detection of Ovarian Cancer using the Risk of Ovarian Cancer Algorithm with Frequent CA125 Testing in Women at Increased Familial Risk – Combined Results from Two Screening Trials

Purpose: Women at familial/genetic ovarian cancer risk often undergo screening despite unproven efficacy. Research suggests each woman has her own CA125 baseline; significant increases above this level may identify cancers earlier than standard 6- to 12-monthly CA125 > 35 U/mL. Experimental Design: Data from prospective Cancer Genetics Network and Gynecologic Oncology Group trials, which screened 3,692 women (13,080 woman-screening years) with a strong breast/ovarian cancer family history or BRCA1/2 mutations, were combined to assess a novel screening strategy. Specifically, serum CA125 q3 months, evaluated using a risk of ovarian cancer algorithm (ROCA), detected significant increases above each subject's baseline, which triggered transvaginal ultrasound. Specificity and positive predictive value (PPV) were compared with levels derived from general population screening (specificity 90%, PPV 10%), and stage-at-detection was compared with historical high-risk controls. Results: Specificity for ultrasound referral was 92% versus 90% ( P = 0.0001), and PPV was 4.6% versus 10% ( P > 0.10). Eighteen of 19 malignant ovarian neoplasms [prevalent = 4, incident = 6, risk-reducing salpingo-oophorectomy (RRSO) = 9] were detected via screening or RRSO. Among incident cases (which best reflect long-term screening performance), three of six invasive cancers were early-stage (I/II; 50% vs. 10% historical BRCA1 controls; P = 0.016). Six of nine RRSO-related cases were stage I. ROCA flagged three of six (50%) incident cases before CA125 exceeded 35 U/mL. Eight of nine patients with stages 0/I/II ovarian cancer were alive at last follow-up (median 6 years). Conclusions: For screened women at familial/genetic ovarian cancer risk, ROCA q3 months had better early-stage sensitivity at high specificity, and low yet possibly acceptable PPV compared with CA125 > 35 U/mL q6/q12 months, warranting further larger cohort evaluation. Clin Cancer Res; 23(14); 3628-37. ©2017 AACR

The Cosmos in its Infancy: JADES Galaxy Candidates at z > 8 in GOODS-S and GOODS-N

We present a catalog of 717 candidate galaxies at $z > 8$ selected from 125 square arcminutes of NIRCam imaging as part of the JWST Advanced Deep Extragalactic Survey (JADES). We combine the full JADES imaging dataset with data from the JEMS and FRESCO JWST surveys along with extremely deep existing observations from HST/ACS for a final filter set that includes fifteen JWST/NIRCam filters and five HST/ACS filters. The high-redshift galaxy candidates were selected from their estimated photometric redshifts calculated using a template fitting approach, followed by visual inspection from seven independent reviewers. We explore these candidates in detail, highlighting interesting resolved or extended sources, sources with very red long-wavelength slopes, and our highest redshift candidates, which extend to $z_{phot} = 18$. We also investigate potential contamination by stellar objects, and do not find strong evidence from SED fitting that these faint high-redshift galaxy candidates are low-mass stars. Over 93\% of the sources are newly identified from our deep JADES imaging, including 31 new galaxy candidates at $z_{phot} > 12$. Using 42 sources in our sample with measured spectroscopic redshifts from NIRSpec and FRESCO, we find excellent agreement to our photometric redshift estimates, with no catastrophic outliers and an average difference of $\langle \Delta z = z_{phot}- z_{spec} \rangle= 0.26$. These sources comprise one of the most robust samples for probing the early buildup of galaxies within the first few hundred million years of the Universe's history.Comment: v2: 40 pages, 18 figures, submitted to AAS Journals, online data catalog (JADES Deep only) found at https://doi.org/10.5281/zenodo.809252

Unified treatment algorithm for the management of crotaline snakebite in the United States: results of an evidence-informed consensus workshop

<p>Abstract</p> <p>Background</p> <p>Envenomation by crotaline snakes (rattlesnake, cottonmouth, copperhead) is a complex, potentially lethal condition affecting thousands of people in the United States each year. Treatment of crotaline envenomation is not standardized, and significant variation in practice exists.</p> <p>Methods</p> <p>A geographically diverse panel of experts was convened for the purpose of deriving an evidence-informed unified treatment algorithm. Research staff analyzed the extant medical literature and performed targeted analyses of existing databases to inform specific clinical decisions. A trained external facilitator used modified Delphi and structured consensus methodology to achieve consensus on the final treatment algorithm.</p> <p>Results</p> <p>A unified treatment algorithm was produced and endorsed by all nine expert panel members. This algorithm provides guidance about clinical and laboratory observations, indications for and dosing of antivenom, adjunctive therapies, post-stabilization care, and management of complications from envenomation and therapy.</p> <p>Conclusions</p> <p>Clinical manifestations and ideal treatment of crotaline snakebite differ greatly, and can result in severe complications. Using a modified Delphi method, we provide evidence-informed treatment guidelines in an attempt to reduce variation in care and possibly improve clinical outcomes.</p

The Cosmos in its Infancy: JADES Galaxy Candidates at z > 8 in GOODS-S and GOODS-N

© 2024. The Author(s). Published by the American Astronomical Society. This is an open access article distributed under the Creative Commons Attribution License, to view a copy of the license, see: https://creativecommons.org/licenses/by/4.0/We present a catalog of 717 candidate galaxies at z > 8 selected from 125 square arcmin of NIRCam imaging as part of the JWST Advanced Deep Extragalactic Survey (JADES). We combine the full JADES imaging data set with data from the JWST Extragalactic Medium Survey and First Reionization Epoch Spectroscopic COmplete Survey (FRESCO) along with extremely deep existing observations from Hubble Space Telescope (HST)/Advanced Camera for Surveys (ACS) for a final filter set that includes 15 JWST/NIRCam filters and five HST/ACS filters. The high-redshift galaxy candidates were selected from their estimated photometric redshifts calculated using a template-fitting approach, followed by visual inspection from seven independent reviewers. We explore these candidates in detail, highlighting interesting resolved or extended sources, sources with very red long-wavelength slopes, and our highest-redshift candidates, which extend to z phot ∼ 18. Over 93% of the sources are newly identified from our deep JADES imaging, including 31 new galaxy candidates at z phot > 12. We also investigate potential contamination by stellar objects, and do not find strong evidence from spectral energy distribution fitting that these faint high-redshift galaxy candidates are low-mass stars. Using 42 sources in our sample with measured spectroscopic redshifts from NIRSpec and FRESCO, we find excellent agreement to our photometric redshift estimates, with no catastrophic outliers and an average difference of 〈Δz = z phot − z spec〉 = 0.26. These sources comprise one of the most robust samples for probing the early buildup of galaxies within the first few hundred million years of the Universe’s history.Peer reviewe

Long-term Site Fidelity and Individual Home Range Shifts in Lophocebus albigena

We investigated long-term site fidelity of gray-cheeked mangabey (Lophocebus albigena) groups in Kibale National Park, Uganda. Concurrently, we monitored shifts in home range by individual females and subadult and adult males. We documented home range stability by calculating the area of overlap in successive years, and by recording the drift of each group’s monthly centroid from its initial location. Home ranges remained stable for 3 of our 4 groups (overlap over 10 yr >60%). Core areas were more labile, but group centroids drifted an average of only 530 m over the entire decade. Deviations from site fidelity were associated with dispersal or group fission. During natal dispersal, subadult males expanded their home ranges over many months, settling ≤4 home ranges away. Adult males, in contrast, typically dispersed within a few days to an adjacent group in an area of home range overlap. Adult males made solitary forays, but nearly always into areas used by their current group or by a group to which they had previously belonged. After secondary dispersal, they expanded their ranging in the company of their new group, apparently without prior solitary exploration of the new area. Some females also participated in home range shifts. Females shifted home ranges only within social groups, in association with temporary or permanent group splits. Our observations raise the possibility that male mangabeys use a finder-joiner mechanism when moving into new home ranges during secondary dispersal. Similarly, females might learn new resource locations from male immigrants before or during group fission

JADES Imaging of GN-z11: Revealing the Morphology and Environment of a Luminous Galaxy 430 Myr After the Big Bang

We present JWST NIRCam 9-band near-infrared imaging of the luminous $z=10.6$ galaxy GN-z11 from the JWST Advanced Deep Extragalactic Survey (JADES) of the GOODS-N field. We find a spectral energy distribution (SED) entirely consistent with the expected form of a high-redshift galaxy: a clear blue continuum from 1.5 to 4 microns with a complete dropout in F115W. The core of GN-z11 is extremely compact in JWST imaging. We analyze the image with a two-component model, using a point source and a S\'{e}rsic profile that fits to a half-light radius of 200 pc and an index $n=0.9$. We find a low-surface brightness haze about $0.4''$ to the northeast of the galaxy, which is most likely a foreground object but might be a more extended component of GN-z11. At a spectroscopic redshift of 10.60 (Bunker et al. 2023), the comparison of the NIRCam F410M and F444W images spans the Balmer jump. From population synthesis modeling, here assuming no light from an active galactic nucleus, we reproduce the SED of GN-z11, finding a stellar mass of $\sim$$10^{9}~M_{\odot}$, a star-formation rate of $\sim$$20~M_{\odot}~\mathrm{yr}^{-1}$ and a young stellar age of $\sim$$20~\mathrm{Myr}$. As massive galaxies at high redshift are likely to be highly clustered, we search for faint neighbors of GN-z11, finding 9 galaxies out to $\sim$5 comoving Mpc transverse with photometric redshifts consistent with $z=10.6$, and a 10$^{\rm th}$ more tentative dropout only $3''$ away.Comment: Submitted to ApJ; 18 pages, 8 figures; comments welcom