531 research outputs found

    Understanding Genre in a Collection of a Million Volumes

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    Large digital collections offer new avenues of exploration for literary scholars. But their potential has not yet been fully realized, because we don’t have the metadata we would need to make literary arguments at scale. Subject classifications don’t reveal, for instance, whether a given volume is poetry, drama, fiction, or criticism. Working with a hand-classified collection of 4,275 English-language works, we have discovered new perspectives on the history of genre. But to flesh out those leads (and permit others to undertake similar projects) we need to move to a scale where manual classification would be impractical. We propose to develop software that can classify volumes by genre while allowing definitions of genre to change over time, and allowing works to belong to multiple genres. We will classify a million-volume collection (1800- 1949), make our data, metadata, and software freely available through HathiTrust Research Center, and publish substantive literary findings

    Phosphorylation is required for the pathogen defense function of the Arabidopsis PEN3 ABC transporter.

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    The Arabidopsis PEN3 ABC transporter accumulates at sites of pathogen detection, where it is involved in defense against a number of pathogens. Perception of PAMPs by pattern recognition receptors initiates recruitment of PEN3 and also leads to PEN3 phosphorylation at multiple amino acid residues. Whether PAMP-induced phosphorylation of PEN3 is important for its defense function or focal recruitment has not been addressed. In this study, we evaluated the role of PEN3 phosphorylation in modulating the localization and defense function of the transporter. We report that PEN3 phosphorylation is critical for its function in defense, but dispensable for recruitment to powdery mildew penetration sites. These results indicate that PAMP-induced phosphorylation is likely to regulate the transport activity of PEN3

    The Plant Cell Wall: A Dynamic Barrier Against Pathogen Invasion

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    Prospective plant pathogens must overcome the physical barrier presented by the plant cell wall. In addition to being a preformed, passive barrier limiting access of pathogens to plant cells, the cell wall is actively remodeled and reinforced specifically at discrete sites of interaction with potentially pathogenic microbes. Active reinforcement of the cell wall through the deposition of cell wall appositions, referred to as papillae, is an early response to perception of numerous categories of pathogens including fungi and bacteria. Rapid deposition of papillae is generally correlated with resistance to fungal pathogens that attempt to penetrate plant cell walls for the establishment of feeding structures. Despite the ubiquity and apparent importance of this early defense response, relatively little is known about the underlying molecular mechanisms and cellular processes involved in the targeting and assembly of papillae. This review summarizes recent advances in our understanding of cell wall-associated defenses induced by pathogen perception as well as the impact of changes in cell wall polymers on interactions with pathogens and highlights significant unanswered questions driving future research in the area

    Cultural Awareness Sensitivity Training

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    In this study, employees of the Federal Correctional Institution in Ashland, Kentucky; the Federal Medical Center in Rochester, Minnesota; and the Federal Correctional Institution in Milan, Michigan were surveyed to determine the need for a Cultural Awareness Sensitivity Training program for staff within the United States Bureau of Prisons. In addition, if the need for this program was established, the Cultural Awareness Study was formulated to determine the scope and breadth of the coverage of the program. The respondents were asked to answer 72 questions in the following areas: (1) diversity training; (2) need assessment; (3) staff demographics; (4) inmate demographics; and (5) survey demographics. From the responses to this survey, a proposed curriculum was developed for initial review at the Federal Correctional Institution in Ashland, Kentucky

    American socio-politics in fictional context: transformers and the representation of the United States

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    The fictional narratives that have been developed for the support of the Transformers brand, with their underlying emphasis on the sale of action figures, have been dismissed as a somewhat juvenile and uninteresting text. Little to no serious academic analysis of any of the various iterations of the franchise has been undertaken. With this thesis, I endeavour to begin that analysis and thus broaden and problematize the currently limited understanding of Transformers fictions. Due to the franchise’s vast nature, I focus on the original animation (1984-1987) and the recent live-action movies (2007-2011) with their attempts to offer a representation of the contemporaneous sociopolitical environment in America at the time of their production. In order to undertake this study, I combine my background in political analysis with film and media studies to seek out and explore the political themes and commentaries present in the key areas of political philosophy, technological change, the depiction of politicians, gender and sexuality, and America’s international role. Through this analysis of the franchise I shall construct an argument that Transformers is a complex narrative, replete with socio-political allegory that offers a representation of the United States and a view of itself in the arenas of domestic and global politics
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