700 research outputs found
DETERMINING LOCATIONS FOR RURAL MEDICAL CLINICS: A MODEL AND ITS USE
Community/Rural/Urban Development,
Interview with Don Hurst
An interview with Don Hurst regarding his experiences in a one-room school house.https://scholars.fhsu.edu/ors/1064/thumbnail.jp
Nurses\u27 Alumnae Association Bulletin - Volume 18 Number 1
Alumnae Notes
Central Dressing Room
Committee Reports
Digest of Alumnae Association Meetings
Graduation Awards - 1952
Greetings from Miss Childs
Greetings from the President
Marriages
Modern Trends in Orthopaedic Surgery
Necrology
New Arrivals
Physical Advances at Jefferson Hospital - 1953
Staff Activities - 1952-1953
Student Activities
The Artificial Heart Lung Machin
Nuclear safety policy working group recommendations on nuclear propulsion safety for the space exploration initiative
An interagency Nuclear Safety Working Group (NSPWG) was chartered to recommend nuclear safety policy, requirements, and guidelines for the Space Exploration Initiative (SEI) nuclear propulsion program. These recommendations, which are contained in this report, should facilitate the implementation of mission planning and conceptual design studies. The NSPWG has recommended a top-level policy to provide the guiding principles for the development and implementation of the SEI nuclear propulsion safety program. In addition, the NSPWG has reviewed safety issues for nuclear propulsion and recommended top-level safety requirements and guidelines to address these issues. These recommendations should be useful for the development of the program's top-level requirements for safety functions (referred to as Safety Functional Requirements). The safety requirements and guidelines address the following topics: reactor start-up, inadvertent criticality, radiological release and exposure, disposal, entry, safeguards, risk/reliability, operational safety, ground testing, and other considerations
Growth of Lion and Puma Lentiviruses in Domestic Cat Cells and Comparisons with FIV
AbstractFeline immunodeficiency virus (FIV-Fca) is a lentivirus that causes gradual immunological deterioration in domestic cats. Lentiviruses related to FIV have been detected in several nondomestic feline species; the biologic significance of these viruses remains to be defined. To examine thein vitrocell tropism of these nondomestic cat lentiviruses, prototypical puma and lion lentiviruses (FIV-Pco and FIV-Ple) were cultured in a variety of feline cell cultures. A domestic cat T lymphoma cell line, 3201, best supported the replication of both FIV-Pco and FIV-Ple. Moreover, FIV-Ple was lytic for these cells. RT-PCR amplification of a conservedpolgene region demonstrated species-specific primer homology. Sequence and phylogenetic analyses of this amplification product confirmed the identity of the replicating viruses and classified two previously uncharacterized viruses within predictable lion and puma clades. Sequence analysis of a conservedpolregion demonstrated homology with previously characterized FIV-Ple and FIV-Pco. Western blot analysis using domestic cat anti-FIV-Fca sera showed that both FIV-Pco and FIV-Ple were antigenically related, to differing degrees, to three serotypes of FIV-Fca. These studies demonstrate that though nondomestic cat lentiviruses differ significantly from FIV-Fca and that a viral-specific protocol may be necessary for sensitive viral detection, these viruses can replicate in cells of domestic cats, suggesting the potential for cross-species transmission
Chatbots and their Applications in E-Commerce
With the growing use of mobile instant messengers around the world, chatbot, a system that automatically communicates with people based on artificial intelligence on a messenger, is drawing attention for its versatility and ability to learn. For our research paper, we decided to gather academic journals and utilize multiple webpages on how chatbots have evolved from simple response AI to intricate and impressive systems that are capable of utilizing speech and conversations to personalize user experience, help with online marketing and shopping, searching the web upon request, and many other functions. Our research concludes that the utilization of chatbots within e-commerce will not only boost online shopping, but it will eventually standardize most of the business transactions done online
The WD40 Domain Is Required for LRRK2 Neurotoxicity
BACKGROUND:Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson disease (PD). LRRK2 contains an "enzymatic core" composed of GTPase and kinase domains that is flanked by leucine-rich repeat (LRR) and WD40 protein-protein interaction domains. While kinase activity and GTP-binding have both been implicated in LRRK2 neurotoxicity, the potential role of other LRRK2 domains has not been as extensively explored. PRINCIPAL FINDINGS:We demonstrate that LRRK2 normally exists in a dimeric complex, and that removing the WD40 domain prevents complex formation and autophosphorylation. Moreover, loss of the WD40 domain completely blocks the neurotoxicity of multiple LRRK2 PD mutations. CONCLUSION:These findings suggest that LRRK2 dimerization and autophosphorylation may be required for the neurotoxicity of LRRK2 PD mutations and highlight a potential role for the WD40 domain in the mechanism of LRRK2-mediated cell death
Transit and Eclipse Analyses of Exoplanet HD 149026b Using BLISS Mapping
The dayside of HD 149026b is near the edge of detectability by the Spitzer
Space Telescope. We report on eleven secondary-eclipse events at 3.6, 4.5, 3 x
5.8, 4 x 8.0, and 2 x 16 microns plus three primary-transit events at 8.0
microns. The eclipse depths from jointly-fit models at each wavelength are
0.040 +/- 0.003% at 3.6 microns, 0.034 +/- 0.006% at 4.5 microns, 0.044 +/-
0.010% at 5.8 microns, 0.052 +/- 0.006% at 8.0 microns, and 0.085 +/- 0.032% at
16 microns. Multiple observations at the longer wavelengths improved
eclipse-depth signal-to-noise ratios by up to a factor of two and improved
estimates of the planet-to-star radius ratio (Rp/Rs = 0.0518 +/- 0.0006). We
also identify no significant deviations from a circular orbit and, using this
model, report an improved period of 2.8758916 +/- 0.0000014 days.
Chemical-equilibrium models find no indication of a temperature inversion in
the dayside atmosphere of HD 149026b. Our best-fit model favors large amounts
of CO and CO2, moderate heat redistribution (f=0.5), and a strongly enhanced
metallicity. These analyses use BiLinearly-Interpolated Subpixel Sensitivity
(BLISS) mapping, a new technique to model two position-dependent systematics
(intrapixel variability and pixelation) by mapping the pixel surface at high
resolution. BLISS mapping outperforms previous methods in both speed and
goodness of fit. We also present an orthogonalization technique for
linearly-correlated parameters that accelerates the convergence of Markov
chains that employ the Metropolis random walk sampler. The electronic
supplement contains light-curve files and supplementary figures.Comment: Accepted for publication in Ap
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