391 research outputs found
User's guide for atmospheric carbon monoxide transport model
In the winter months of Fairbanks, Alaska, a highly stable air temperature
inversion creates high levels of carbon monoxide (CO) concentrations. As an aid
to understanding this problem, a CO transport computer model has been created
which provides a useful tool when used in conjunction with other measurement and
analytic studies of traffic, meteorology, emissions control, zoning, and parking
management. The model is completely documented and illustrated with several
examples. Named ACOSP (Atmospheric CO Simulation Program), it predicts expected
CO concentrations within a specific geographic area for a defined set of CO
sources. At the present time, the model is programmed to consider automobile
emissions as the major CO source and may include estimates of stationary sources.
The model is coded for computer solution in the FORTRAN programming language and
uses the finite-element method of numerical solution of the basic convective-diffusion
equations. Although it has a potential for real-time analysis and control,
at the present time the model will be most valuable for investigating and understanding
the physical processes which are responsible for high CO levels and for
testing remedial control measures at high speed and low cost
Zebrafish Optokinetic Reflex: Minimal Reporting Guidelines and Recommendations
Optokinetic reflex (OKR) assays in zebrafish models are a valuable tool for studying a diverse range of ophthalmological and neurological conditions. Despite its increasing popularity in recent years, there are no clear reporting guidelines for the assay. Following reporting guidelines in research enhances reproducibility, reduces bias, and mitigates underreporting and poor methodologies in published works. To better understand optimal reporting standards for an OKR assay in zebrafish, we performed a systematic literature review exploring the animal, environmental, and technical factors that should be considered. Using search criteria from three online databases, a total of 109 research papers were selected for review. Multiple crucial factors were identified, including larval characteristics, sample size, fixing method, OKR set-up, distance of stimulus, detailed stimulus parameters, eye recording, and eye movement analysis. The outcome of the literature analysis highlighted the insufficient information provided in past research papers and the lack of a systematic way to present the parameters related to each of the experimental factors. To circumvent any future errors and champion robust transparent research, we have created the zebrafish optokinetic (ZOK) reflex minimal reporting guideline
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A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies.
Primary tauopathies are characterized neuropathologically by inclusions containing abnormal forms of the microtubule-associated protein tau (MAPT) and clinically by diverse neuropsychiatric, cognitive, and motor impairments. Autosomal dominant mutations in the MAPT gene cause heterogeneous forms of frontotemporal lobar degeneration with tauopathy (FTLD-Tau). Common and rare variants in the MAPT gene increase the risk for sporadic FTLD-Tau, including progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). We generated a collection of fibroblasts from 140 MAPT mutation/risk variant carriers, PSP, CBD, and cognitively normal controls; 31 induced pluripotent stem cell (iPSC) lines from MAPT mutation carriers, non-carrier family members, and autopsy-confirmed PSP patients; 33 genome engineered iPSCs that were corrected or mutagenized; and forebrain neural progenitor cells (NPCs). Here, we present a resource of fibroblasts, iPSCs, and NPCs with comprehensive clinical histories that can be accessed by the scientific community for disease modeling and development of novel therapeutics for tauopathies
The thermal emission of the exoplanets WASP-1b and WASP-2b
We present a comparative study of the thermal emission of the transiting
exoplanets WASP-1b and WASP-2b using the Spitzer Space Telescope. The two
planets have very similar masses but suffer different levels of irradiation and
are predicted to fall either side of a sharp transition between planets with
and without hot stratospheres. WASP-1b is one of the most highly irradiated
planets studied to date. We measure planet/star contrast ratios in all four of
the IRAC bands for both planets (3.6-8.0um), and our results indicate the
presence of a strong temperature inversion in the atmosphere of WASP-1b,
particularly apparent at 8um, and no inversion in WASP-2b. In both cases the
measured eclipse depths favor models in which incident energy is not
redistributed efficiently from the day side to the night side of the planet. We
fit the Spitzer light curves simultaneously with the best available radial
velocity curves and transit photometry in order to provide updated measurements
of system parameters. We do not find significant eccentricity in the orbit of
either planet, suggesting that the inflated radius of WASP-1b is unlikely to be
the result of tidal heating. Finally, by plotting ratios of secondary eclipse
depths at 8um and 4.5um against irradiation for all available planets, we find
evidence for a sharp transition in the emission spectra of hot Jupiters at an
irradiation level of 2 x 10^9 erg/s/cm^2. We suggest this transition may be due
to the presence of TiO in the upper atmospheres of the most strongly irradiated
hot Jupiters.Comment: 10 pages, submitted to Ap
International Survey of Patients With IBS: Symptom Features and Their Severity, Health Status, Treatments, and Risk Taking to Achieve Clinical Benefit
While clinicians generally make treatment decisions in IBS related to the type of symptoms, other factors such as the perceived severity and the risks patients are willing to tolerate for effective treatment are also important to consider. These factors are not fully understood
Smoke gets in your eyes: re-reading gender in the "nostalgia film"
Upon its release, American Graffiti (George Lucas, 1973) was much admired by critics and audiences alike. Yet, in subsequent years, the film became known for its supposed “flattening of history,” and celebration of patriarchal values. This article demonstrates that such a judgement owes much to Fredric Jameson’s historically contingent work on postmodernism, which argues that American Graffiti constitutes the paradigmatic nostalgia film. In contrast, using close textual analysis, I demonstrate that American Graffiti provides a more complex construction of the past, and of gender, than has hitherto been acknowledged. Far from blindly idealising the early 1960s, the film interrogates the processes through which the period and its gender relations come to be idealised. This article has consequences not only for our understanding of Lucas’ seminal film, but also for the American New Wave, and the “nostalgia” text
Search for CP Violation in the Decay Z -> b (b bar) g
About three million hadronic decays of the Z collected by ALEPH in the years
1991-1994 are used to search for anomalous CP violation beyond the Standard
Model in the decay Z -> b \bar{b} g. The study is performed by analyzing
angular correlations between the two quarks and the gluon in three-jet events
and by measuring the differential two-jet rate. No signal of CP violation is
found. For the combinations of anomalous CP violating couplings, and , limits of \hat{h}_b < 0.59h^{\ast}_{b} < 3.02$ are given at 95\% CL.Comment: 8 pages, 1 postscript figure, uses here.sty, epsfig.st
Communications Biophysics
Contains reports on four research projects.National Institutes of Health (Grant 5 P01 NS13126-02)National Institutes of Health (Grant 5 K04 NS00113-03)National Institutes of Health (Grant 2 ROI NS11153-02A1)National Science Foundation (Grant BNS77-16861)National Institutes of Health (Grant 5 RO1 NS10916-03)National Institutes of Health (Fellowship 1 F32 NS05327)National Institutes of Health (Grant 5 ROI NS12846-02)National Institutes of Health (Fellowship 1 F32 NS05266)Edith E. Sturgis FoundationNational Institutes of Health (Grant 1 R01 NS11680-01)National Institutes of Health (Grant 2 RO1 NS11080-04)National Institutes of Health (Grant 5 T32 GIM107301-03)National Institutes of Health (Grant 5 TOI GM01555-10
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‘Caution! The Bread is Poisoned’: The Hong Kong Mass Poisoning of January 1857
This article examines the Hong Kong mass poisoning of 15 January 1857, in which bread from a Chinese bakery that supplied the colonial community was adulterated with arsenic. Even though there is a wealth of printed and manuscript documentation available many vital aspects of the poisoning remain unclear. What kind of incident was it: an act of terrorism and attempted mass murder, a war crime, a criminal conspiracy, an act of commercial sabotage, an accident or even an imagined or imaginary event? Throughout, our focus remains firmly fixed on the central act of the poisoning itself and on what it reveals about the precarious nature of early colonial Hong Kong. Interpretations have swarmed over the available ‘facts'. Equally ironic is what happened to the afterlife of how the event was understood. This article seeks to rescue the Hong Kong poisoning from being a freakish and isolated footnote of only local interest. Accepting this historical verdict would be a mistake as it is of significance not only at a local level, but geopolitically in Britain and across the empire
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