Macroeconomic price indexes

Price Indexes allow one to compare the average levels of prices at different times. Despite their widespread use, price indexes do not answer all questions as well as analysts might wish. Macroeconomic Price Indexes is a guide for users of major price indexes. It provides details about several price indexes to help users intelligently decide what they can learn by using particular indexes.Macroeconomics ; Prices

Applying the Common Sense Model to predicting quality of life in alopecia areata: The role of illness perceptions and coping strategies

Item does not contain fulltextApplying the Common Sense Model, this cross-sectional study examines associations between illness perceptions and quality of life and the mediating role of coping in 243 adults with alopecia areata, a chronic dermatological condition. At least some QoL impairment was reported by 84 percent of participants, with 31 percent reporting very to extremely large impairment. Stronger perceptions of consequences, emotional representations, identity, and lower attribution to chance were related to more impairment, with avoidant coping acting as (partial) mediator. Illness perceptions and avoidant coping seem to play an important role in QoL and are relevant intervention targets in alopecia areata

The Best of Both Worlds: Model-Driven Engineering Meets Model-Based Testing

We study the connection between stable-failures refinement and the ioco conformance relation. Both behavioural relations underlie methodologies that have gained traction in industry: stable-failures refinement is used in several commercial Model-Driven Engineering tool suites, whereas the ioco conformance relation is used in Model-Based Testing tools. Refinement-based Model-Driven Engineering approaches promise to generate executable code from high-level models, thus guaranteeing that the code upholds specified behavioural contracts. Manual testing, however, is still required to gain confidence that the model-to-code transformation and the execution platform do not lead to unexpected contract violations. We identify conditions under which also this last step in the design methodology can be automated using the ioco conformance relation and the associated tools

Feasibility of a dose-intensive CMF regimen with granulocyte colony-stimulating factor as adjuvant therapy in premenopausal patients with node-positive breast cancer

Our aim was to study the feasibility of an intensified intravenous CMF (cyclophosphamide, methotrexate and 5-fluorouracil) schedule with the aim to escalate dose intensity (DI). Twenty-three premenopausal breast cancer patients received 6 cycles of adjuvant CMF intravenously on days 1 and 8 every 3 weeks and granulocyte colony-stimulating factor days 9–18. Endpoints were DI and toxicity. Twenty-one out of 23 patients (91%) received the projected total dose and reached ≥ 85% of the projected DI. Compared to ‘classical’ CMF, all patients reached ≥ 111% DI. Nine patients received the planned schedule without delay. Thirteen patients (57%) were treated for infection and four patients (17%) were hospitalized for febrile neutropenia. Twelve patients received red blood cell transfusions (52%). Radiation therapy (n= 6) had no adverse impact on dose intensity or haematological toxicity. This dose-intensified CMF schedule was accompanied by enhanced haematological toxicity with clinical sequelae, namely fever, intravenous antibiotics and red blood cell transfusions, but allows a high dose intensity in a majority of patients. © 2000 Cancer Research Campaig

Disruption of Cxcr3 chemotactic signaling alters lysosomal function and renders macrophages more microbicidal

Chemotaxis and lysosomal function are closely intertwined processes essential for the inflammatory response and clearance of intracellular bacteria. We used the zebrafish model to examine the link between chemotactic signaling and lysosome physiology in macrophages during mycobacterial infection and wound-induced inflammation in vivo. Macrophages from zebrafish larvae carrying a mutation in a chemokine receptor of the Cxcr3 family display upregulated expression of vesicle trafficking and lysosomal genes and possess enlarged lysosomes that enhance intracellular bacterial clearance. This increased microbicidal capacity is phenocopied by inhibiting the lysosomal transcription factor EC, while its overexpression counteracts the protective effect of chemokine receptor mutation. Tracking macrophage migration in zebrafish revealed that lysosomes of chemokine receptor mutants accumulate in the front half of cells, preventing macrophage polarization during chemotaxis and reaching sites of inflammation. Our work shows that chemotactic signaling affects the bactericidal properties and localization during chemotaxis, key aspects of the inflammatory response

De invloed van de hokvorm op de bevuiling bij gespeende biggen

Op het Varkensproefbedrijf in Raalte zijn in 1992 waarnemingen verricht naar de bevuiling van verschillende vloeruitvoeringen bij gespeende biggen. Het betrof in alle gevallen hokken uitgevoerd met een smal rooster, een dichte bolle vloer en een grootrooster