Comparison of hot wire/laser velocimeter turbulence intensity measurements

The question of whether a random measure of particle velocities yields a good statistical estimate of the stationary condition of the turbulence flow field was investigated by comparing hot-wire and laser velocimeter turbulence intensity measurements. Great care was taken to insure that the instrument precision of both the laser velocimeter and hot wire was maximized. In this attempt to reduce the measurement uncertainties in the hot wire, direct digitization of the analog output signal was performed with point-by-point conversion to velocity through a spline fit calibration curve and the turbulence intensity function was calculated statistically. Frequent calibrations of the hot wire were performed using the laser velocimeter as the velocity standard to account for the presence of the small seed particles in the air flow and signal drift in the hot wire

High-contrast imaging of 180{\deg} ferroelectric domains by optical microscopy using ferroelectric liquid crystals

Ferroelectric liquid crystals (FLCs) couple the direction of their spontaneous electric polarization to the direction of tilt of their optic axis. Consequently, reversal of the electric polarization by an electric field gives rise to an immediate and lasting optical response when an appropriately aligned FLC is observed between crossed polarizers, with one field direction yielding a dark image, and the opposite direction yielding a bright image. Here this peculiar electro-optic response is used to image, with high optical contrast, 180{\deg} ferroelectric domains in a crystalline substrate of magnesium-doped lithium niobate. The lithium niobate substrate contains a few domains with upwards electric polarization surrounded by regions with downward electric polarization. In contrast to a reference non-chiral liquid crystal that is unable to show ferroelectric behavior due to its high symmetry, the FLC, which is used as a thin film confined between the lithium niobate substrate and an inert aligning substrate, reveals ferroelectric domains as well as their boundaries, with strong black and white contrast. The results show that FLCs can be used for non-destructive read-out of domains in underlying ferroelectrics, with potential applications in e.g. photonic devices and non-volatile ferroelectric memories.Comment: 12 pages, 3 figure

Band Distributions for Quantum Chaos on the Torus

Band distributions (BDs) are introduced describing quantization in a toral phase space. A BD is the uniform average of an eigenstate phase-space probability distribution over a band of toral boundary conditions. A general explicit expression for the Wigner BD is obtained. It is shown that the Wigner functions for {\em all} of the band eigenstates can be reproduced from the Wigner BD. Also, BDs are shown to be closer to classical distributions than eigenstate distributions. Generalized BDs, associated with sets of adjacent bands, are used to extend in a natural way the Chern-index characterization of the classical-quantum correspondence on the torus to arbitrary rational values of the scaled Planck constant.Comment: 12 REVTEX page

Challenges of ultra large scale integration of biomedical computing systems

The NCRI Informatics Initiative is overseeing the implementation of an informatics framework for the UK cancer research community. The framework advocates an integrated multidisciplinary method of working between scientific and medical communities. Key to this process is community adoption of high quality acquisition, storage, sharing and integration of diverse data elements to improve knowledge of the causes, prevention and treatment of cancer. The integration of the complex data and meta-data used by these multiple communities is a significant challenge and there are technical, resource-based and sociological issues to be addressed. In this paper we review progress aimed at establishing the framework and outline key challenges in ultra large scale integration of biomedical computing systems

Tridiagonal realization of the anti-symmetric Gaussian β\beta-ensemble

The Householder reduction of a member of the anti-symmetric Gaussian unitary ensemble gives an anti-symmetric tridiagonal matrix with all independent elements. The random variables permit the introduction of a positive parameter $\beta$, and the eigenvalue probability density function of the corresponding random matrices can be computed explicitly, as can the distribution of $\{q_i\}$, the first components of the eigenvectors. Three proofs are given. One involves an inductive construction based on bordering of a family of random matrices which are shown to have the same distributions as the anti-symmetric tridiagonal matrices. This proof uses the Dixon-Anderson integral from Selberg integral theory. A second proof involves the explicit computation of the Jacobian for the change of variables between real anti-symmetric tridiagonal matrices, its eigenvalues and $\{q_i\}$. The third proof maps matrices from the anti-symmetric Gaussian $\beta$-ensemble to those realizing particular examples of the Laguerre $\beta$-ensemble. In addition to these proofs, we note some simple properties of the shooting eigenvector and associated Pr\"ufer phases of the random matrices.Comment: 22 pages; replaced with a new version containing orthogonal transformation proof for both cases (Method III

Higher Order Correlations in Quantum Chaotic Spectra

The statistical properties of the quantum chaotic spectra have been studied, so far, only up to the second order correlation effects. The numerical as well as the analytical evidence that random matrix theory can successfully model the spectral fluctuatations of these systems is available only up to this order. For a complete understanding of spectral properties it is highly desirable to study the higher order spectral correlations. This will also inform us about the limitations of random matrix theory in modelling the properties of quantum chaotic systems. Our main purpose in this paper is to carry out this study by a semiclassical calculation for the quantum maps; however results are also valid for time-independent systems.Comment: Revtex, Four figures (Postscript files), Phys. Rev E (in press

Two tails in NGC 3656, and the major merger origin of shell and minor axis dust lane ellipticals

I report on the discovery of two faint (~ 26.8 Rmag/arcsec^2) tidal tails around the shell elliptical NGC 3656 (Arp 155). This galaxy had previously been interpreted as a case of accretion, or minor merger. The two tidal tails are inconsistent with a minor merger, and point instead to a disk-disk major merger origin. NGC 3656 extends Toomre's merger sequence toward normal elliptical galaxies, and hints at a major merger origin for shells and minor-axis dust lanes. A dwarf galaxy lies at the tip of one of the tidal tails. A prominent shell, which shows sharp azymuthal color discontinuities, belongs to a rotating dynamical component of young stars which includes the inner dust lane.Comment: 9 pages, 2 plates, 1 figure, uses aaspp.sty, accepted for publication in The Astrophysical Journal Letters. Files also available by anonymous ftp at ftp.iac.es, directory ./pub/balcell

Membrane Type 1 Matrix Metalloproteinase Regulates Monocyte Migration and Collagen Destruction in Tuberculosis

Tuberculosis (TB) remains a global pandemic and drug resistance is rising. Multicellular granuloma formation is the pathological hallmark of Mycobacterium tuberculosis infection. The membrane type 1 matrix metalloproteinase (MT1-MMP or MMP-14) is a collagenase that is key in leukocyte migration and collagen destruction. In patients with TB, induced sputum MT1-MMP mRNA levels were increased 5.1-fold compared with matched controls and correlated positively with extent of lung infiltration on chest radiographs (r = 0.483; p < 0.05). M. tuberculosis infection of primary human monocytes increased MT1-MMP surface expression 31.7-fold and gene expression 24.5-fold. M. tuberculosis-infected monocytes degraded collagen matrix in an MT1-MMP-dependent manner, and MT1-MMP neutralization decreased collagen degradation by 73%. In human TB granulomas, MT1-MMP immunoreactivity was observed in macrophages throughout the granuloma. Monocyte-monocyte networks caused a 17.5-fold increase in MT1-MMP surface expression dependent on p38 MAPK and G protein-coupled receptor-dependent signaling. Monocytes migrating toward agarose beads impregnated with conditioned media from M. tuberculosis-infected monocytes expressed MT1-MMP. Neutralization of MT1-MMP activity decreased this M. tuberculosis network-dependent monocyte migration by 44%. Taken together, we demonstrate that MT1-MMP is central to two key elements of TB pathogenesis, causing collagen degradation and regulating monocyte migration

Effects of Electron Correlations on Hofstadter Spectrum

By allowing interactions between electrons, a new Harper's equation is derived to examine the effects of electron correlations on the Hofstadter energy spectra. It is shown that the structure of the Hofstadter butterfly ofr the system of correlated electrons is modified only in the band gaps and the band widths, but not in the characteristics of self-similarity and the Cantor set.Comment: 13 pages, 5 Postscript figure

Topological properties of quantum periodic Hamiltonians

We consider periodic quantum Hamiltonians on the torus phase space (Harper-like Hamiltonians). We calculate the topological Chern index which characterizes each spectral band in the generic case. This calculation is made by a semi-classical approach with use of quasi-modes. As a result, the Chern index is equal to the homotopy of the path of these quasi-modes on phase space as the Floquet parameter (\theta) of the band is varied. It is quite interesting that the Chern indices, defined as topological quantum numbers, can be expressed from simple properties of the classical trajectories.Comment: 27 pages, 14 figure