The WaZP galaxy cluster sample of the dark energy survey year 1

We present a new (2+1)D galaxy cluster finder based on photometric redshifts called Wavelet Z Photometric (WaZP) applied to DES first year (Y1A1) data. The results are compared to clusters detected by the South Pole Telescope (SPT) survey and the redMaPPer cluster finder, the latter based on the same photometric data. WaZP searches for clusters in wavelet-based density maps of galaxies selected in photometric redshift space without any assumption on the cluster galaxy populations. The comparison to other cluster samples was performed with a matching algorithm based on angular proximity and redshift difference of the clusters. It led to the development of a new approach to match two optical cluster samples, following an iterative approach to minimize incorrect associations. The WaZP cluster finder applied to DES Y1A1 galaxy survey (1511.13 deg2 up to mi = 23 mag) led to the detection of 60 547 galaxy clusters with redshifts 0.05 <z< 0.9 and richness Ngals ≥ 5. Considering the overlapping regions and redshift ranges between the DES Y1A1 and SPT cluster surveys, all SZ based SPT clusters are recovered by the WaZP sample. The comparison between WaZP and redMaPPer cluster samples showed an excellent overall agreement for clusters with richness Ngals (λ for redMaPPer) greater than 25 (20), with 95 per cent recovery on both directions. Based on the cluster cross-match, we explore the relative fragmentation of the two cluster samples and investigate the possible signatures of unmatched clusters

Early Developing Pig Embryos Mediate Their Own Environment in the Maternal Tract

The maternal tract plays a critical role in the success of early embryonic development providing an optimal environment for establishment and maintenance of pregnancy. Preparation of this environment requires an intimate dialogue between the embryo and her mother. However, many intriguing aspects remain unknown in this unique communication system. To advance our understanding of the process by which a blastocyst is accepted by the endometrium and better address the clinical challenges of infertility and pregnancy failure, it is imperative to decipher this complex molecular dialogue. The objective of the present work is to define the local response of the maternal tract towards the embryo during the earliest stages of pregnancy. We used a novel in vivo experimental model that eliminated genetic variability and individual differences, followed by Affymetrix microarray to identify the signals involved in this embryo-maternal dialogue. Using laparoscopic insemination one oviduct of a sow was inseminated with spermatozoa and the contralateral oviduct was injected with diluent. This model allowed us to obtain samples from the oviduct and the tip of the uterine horn containing either embryos or oocytes from the same sow. Microarray analysis showed that most of the transcripts differentially expressed were down-regulated in the uterine horn in response to blastocysts when compared to oocytes. Many of the transcripts altered in response to the embryo in the uterine horn were related to the immune system. We used an in silico mathematical model to demonstrate the role of the embryo as a modulator of the immune system. This model revealed that relatively modest changes induced by the presence of the embryo could modulate the maternal immune response. These findings suggested that the presence of the embryo might regulate the immune system in the maternal tract to allow the refractory uterus to tolerate the embryo and support its development

Pleiotropic Effects of Deubiquitinating Enzyme Ubp5 on Growth and Pathogenesis of Cryptococcus neoformans

Ubiquitination is a reversible protein modification that influences various cellular processes in eukaryotic cells. Deubiquitinating enzymes remove ubiquitin, maintain ubiquitin homeostasis and regulate protein degradation via the ubiquitination pathway. Cryptococcus neoformans is an important basidiomycete pathogen that causes life-threatening meningoencephalitis primarily in the immunocompromised population. In order to understand the possible influence deubiquitinases have on growth and virulence of the model pathogenic yeast Cryptococcus neoformans, we generated deletion mutants of seven putative deubiquitinase genes. Compared to other deubiquitinating enzyme mutants, a ubp5Δ mutant exhibited severely attenuated virulence and many distinct phenotypes, including decreased capsule formation, hypomelanization, defective sporulation, and elevated sensitivity to several external stressors (such as high temperature, oxidative and nitrosative stresses, high salts, and antifungal agents). Ubp5 is likely the major deubiquitinating enzyme for stress responses in C. neoformans, which further delineates the evolutionary divergence of Cryptococcus from the model yeast S. cerevisiae, and provides an important paradigm for understanding the potential role of deubiquitination in virulence by other pathogenic fungi. Other putative deubiquitinase mutants (doa4Δ and ubp13Δ) share some phenotypes with the ubp5Δ mutant, illustrating functional overlap among deubiquitinating enzymes in C. neoformans. Therefore, deubiquitinating enzymes (especially Ubp5) are essential for the virulence composite of C. neoformans and provide an additional yeast survival and propagation advantage in the host

Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain

The immune response in the brain has been widely investigated and while many studies have focused on the proinflammatory cytotoxic response, the brain’s innate immune system demonstrates significant heterogeneity. Microglia, like other tissue macrophages, participate in repair and resolution processes after infection or injury to restore normal tissue homeostasis. This review examines the mechanisms that lead to reduction of self-toxicity and to repair and restructuring of the damaged extracellular matrix in the brain. Part of the resolution process involves switching macrophage functional activation to include reduction of proinflammatory mediators, increased production and release of anti-inflammatory cytokines, and production of cytoactive factors involved in repair and reconstruction of the damaged brain. Two partially overlapping and complimentary functional macrophage states have been identified and are called alternative activation and acquired deactivation. The immunosuppressive and repair processes of each of these states and how alternative activation and acquired deactivation participate in chronic neuroinflammation in the brain are discussed

Timing the r-process enrichment of the ultra-faint dwarf galaxy Reticulum II

The ultra-faint dwarf galaxy Reticulum II (Ret II) exhibits a unique chemical evolution history, with - + 72 12 10% of its stars strongly enhanced in r-process elements. We present deep Hubble Space Telescope photometry of Ret II and analyze its star formation history. As in other ultra-faint dwarfs, the color–magnitude diagram is best fit by a model consisting of two bursts of star formation. If we assume that the bursts were instantaneous, then the older burst occurred around the epoch of reionization, forming ∼80% of the stars in the galaxy, while the remainder of the stars formed ∼3 Gyr later. When the bursts are allowed to have nonzero durations, we obtain slightly better fits. The best-fitting model in this case consists of two bursts beginning before reionization, with approximately half the stars formed in a short (100 Myr) burst and the other half in a more extended period lasting 2.6 Gyr. Considering the full set of viable star formation history models, we find that 28% of the stars formed within 500 ± 200 Myr of the onset of star formation. The combination of the star formation history and the prevalence of r-process-enhanced stars demonstrates that the r-process elements in Ret II must have been synthesized early in its initial star-forming phase. We therefore constrain the delay time between the formation of the first stars in Ret II and the r-process nucleosynthesis to be less than 500 Myr. This measurement rules out an r-process source with a delay time of several Gyr or more, such as GW170817

The WaZP galaxy cluster sample of the dark energy survey year 1

Aguena, M., et al.We present a new (2+1)D galaxy cluster finder based on photometric redshifts called Wavelet Z Photometric (WaZP) applied to DES first year (Y1A1) data. The results are compared to clusters detected by the South Pole Telescope (SPT) survey and the redMaPPer cluster finder, the latter based on the same photometric data. WaZP searches for clusters in wavelet-based density maps of galaxies selected in photometric redshift space without any assumption on the cluster galaxy populations. The comparison to other cluster samples was performed with a matching algorithm based on angular proximity and redshift difference of the clusters. It led to the development of a new approach to match two optical cluster samples, following an iterative approach to minimize incorrect associations. The WaZP cluster finder applied to DES Y1A1 galaxy survey (1511.13 deg2 up to mi = 23 mag) led to the detection of 60 547 galaxy clusters with redshifts 0.05 < z < 0.9 and richness Ngals ≥ 5. Considering the overlapping regions and redshift ranges between the DES Y1A1 and SPT cluster surveys, all sz based SPT clusters are recovered by the WaZP sample. The comparison between WaZP and redMaPPer cluster samples showed an excellent overall agreement for clusters with richness Ngals (λ for redMaPPer) greater than 25 (20), with 95 per cent recovery on both directions. Based on the cluster cross-match, we explore the relative fragmentation of the two cluster samples and investigate the possible signatures of unmatched clusters.The DES data management system is supported by the National Science Foundation under Grant Numbers AST-1138766 and AST-1536171. The DES participants from Spanish institutions are partially supported by MICINN under grants ESP2017-89838, PGC2018-094773, PGC2018-102021, SEV-2016-0588, SEV-2016-0597, and MDM-2015-0509, some of which include ERDF funds from the European Union. IFAE is partially funded by the CERCA program of the Generalitat de Catalunya. Research leading to these results has received funding from the European Research Council under the European Union’s Seventh Framework Program (FP7/2007-2013) including ERC grant agreements 240672, 291329, and 306478. We acknowledge support from the Brazilian Instituto Nacional de Ciência e Tecnologia (INCT) do e-Universo (CNPq grant 465376/2014-2)

No evidence for orbital clustering in the extreme trans-Neptunian objects

Napier, K. J., et al. (DES Collaboration)The apparent clustering in longitude of perihelion ϖ and ascending node Ω of extreme trans-Neptunian objects (ETNOs) has been attributed to the gravitational effects of an unseen 5–10 Earth-mass planet in the outer solar system. To investigate how selection bias may contribute to this clustering, we consider 14 ETNOs discovered by the Dark Energy Survey, the Outer Solar System Origins Survey, and the survey of Sheppard and Trujillo. Using each survey's published pointing history, depth, and TNO tracking selections, we calculate the joint probability that these objects are consistent with an underlying parent population with uniform distributions in ϖ and Ω. We find that the mean scaled longitude of perihelion and orbital poles of the detected ETNOs are consistent with a uniform population at a level between 17% and 94% and thus conclude that this sample provides no evidence for angular clustering.The DES participants from Spanish institutions are partially supported by MICINN under grants ESP2017-89838, PGC2018-094773, PGC2018-102021, SEV2016-0588, SEV-2016-0597, and MDM-2015-0509, some of which include ERDF funds from the European Union. The IFAE is partially funded by the CERCA program of the Generalitat de Catalunya. Research leading to these results has received funding from the European Research Council under the European Unionʼs Seventh Framework Program (FP7/ 2007-2013), including ERC grant agreements 240672, 291329, and 306478. We acknowledge support from the Brazilian Instituto Nacional de Ciência e Tecnologia (INCT) do e-Universo (CNPq grant 465376/2014-2)

Dark energy survey internal consistency tests of the joint cosmological probes analysis with posterior predictive distributions

Doux, C., et al. DES CollaborationBeyond ΛCDM, physics or systematic errors may cause subsets of a cosmological data set to appear inconsistent when analysed assuming ΛCDM. We present an application of internal consistency tests to measurements from the Dark Energy Survey Year 1 (DES Y1) joint probes analysis. Our analysis relies on computing the posterior predictive distribution (PPD) for these data under the assumption of ΛCDM. We find that the DES Y1 data have an acceptable goodness of fit to ΛCDM, with a probability of finding a worse fit by random chance of p = 0.046. Using numerical PPD tests, supplemented by graphical checks, we show that most of the data vector appears completely consistent with expectations, although we observe a small tension between large- and small-scale measurements. A small part (roughly 1.5 per cent) of the data vector shows an unusually large departure from expectations; excluding this part of the data has negligible impact on cosmological constraints, but does significantly improve the p-value to 0.10. The methodology developed here will be applied to test the consistency of DES Year 3 joint probes data sets.Based, in part, on observations at Cerro Tololo Inter-American Observatory at NSF’s NOIRLab (NOIRLab Prop. ID 2012B-0001; PI: J. Frieman), which is managed by the Association of Universities for Research in Astronomy (AURA) under a cooperative agreement with the National Science Foundation. The DES data management system is supported by the National Science Foundation under grant numbers AST-1138766 and AST-1536171. The DES participants from Spanish institutions are partially supported by MICINN under grants ESP2017-89838, PGC2018-094773, PGC2018-102021, SEV-2016-0588, SEV-2016-0597, and MDM-2015-0509, some of which include ERDF funds from the European Union. IFAE is partially funded by the CERCA program of the Generalitat de Catalunya. Research leading to these results has received funding from the European Research Council under the European Union’s Seventh Framework Program (FP7/2007-2013) including ERC grant agreements 240672, 291329, and 306478. We acknowledge support from the Brazilian Instituto Nacional de Ciência e Tecnologia (INCT) do e-Universo (CNPq grant 465376/2014-2). This manuscript has been authored by Fermi Research Alliance, LLC under contract no. DE-AC02-07CH11359 with the U.S. Department of Energy, Office of Science, Office of High Energy Physics

A Deeper Look at des Dwarf Galaxy Candidates: Grus i and Indus ii

Cantu, Sarah A., et al. DES CollaborationWe present deep g- and r-band Magellan/Megacam photometry of two dwarf galaxy candidates discovered in the Dark Energy Survey (DES), Grus i and Indus ii (DES J2038-4609). For the case of Grus i, we resolved the main sequence turn-off (MSTO) and ∼2 mags below it. The MSTO can be seen at g 0 ∼ 24 with a photometric uncertainty of 0.03 mag. We show Grus i to be consistent with an old, metal-poor (∼13.3 Gyr, [Fe/H] ∼ -1.9) dwarf galaxy. We derive updated distance and structural parameters for Grus i using this deep, uniform, wide-field data set. We find an azimuthally-averaged halflight radius more than two times larger (∼151+21-31 pc; ∼ 4′.16-0.74+0.54) and an absolute V-band magnitude ∼-4.1 that is ∼1 magnitude brighter than previous studies. We obtain updated distance, ellipticity, and centroid parameters that are in agreement with other studies within uncertainties. Although our photometry of Indus ii is ∼2-3 magnitudes deeper than the DES Y1 public release, we find no coherent stellar population at its reported location. The original detection was located in an incomplete region of sky in the DES Y2Q1 data set and was flagged due to potential blue horizontal branch member stars. The best-fit isochrone parameters are physically inconsistent with both dwarf galaxies and globular clusters. We conclude that Indus ii is likely a false positive, flagged due to a chance alignment of stars along the line of sight

OzDES multi-object fibre spectroscopy for the Dark Energy Survey: Results and second data release

We present a description of the Australian Dark Energy Survey (OzDES) and summarize the results from its 6 years of operations. Using the 2dF fibre positioner and AAOmega spectrograph on the 3.9-m Anglo-Australian Telescope, OzDES has monitored 771 active galactic nuclei, classified hundreds of supernovae, and obtained redshifts for thousands of galaxies that hosted a transient within the 10 deep fields of the Dark Energy Survey. We also present the second OzDES data release, containing the redshifts of almost 30 000 sources, some as faint as r = 24 mag, and 375 000 individual spectra. These data, in combination with the time-series photometry from the Dark Energy Survey, will be used to measure the expansion history of the Universe out to z ∼1.2 and the masses of hundreds of black holes out to z ∼4. OzDES is a template for future surveys that combine simultaneous monitoring of targets with wide-field imaging cameras and wide-field multi-object spectrographs.Funding for the DES Projects has been provided by the U.S. Department of Energy, the U.S. National Science Foundation, the Ministry of Science and Education of Spain, the Science and Technology Facilities Council of the United Kingdom, the Higher Education Funding Council for England, the National Center for Supercomputing Applications at the University of Illinois at Urbana-Champaign, the Kavli Institute of Cosmological Physics at the University of Chicago, the Center for Cosmology and Astro-Particle Physics at the Ohio State University, the Mitchell Institute for Fundamental Physics and Astronomy at Texas A&M University, Fi-nanciadora de Estudos e Projetos, Fundac¸ão Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro, Conselho Nacional de Desenvolvimento Científico e Tecnológico and the Ministério da Ciência, Tecnologia e Inovação, the Deutsche Forschungsgemein-schaft, and the Collaborating Institutions in the DES. LG was funded by the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement no. 839090. The DES data management system is supported by the National Science Foundation under Grant Numbers AST-1138766 and AST-1536171. The DES participants from Spanish institutions are partially supported by MINECO under grants AYA2015-71825, ESP2015-66861, FPA2015-68048, SEV-2016-0588, SEV-2016-0597, and MDM-2015-0509, some of which include ERDF funds from the European Union. IFAE is partially funded by the CERCA program of the Generalitat de Catalunya. Research leading to these results has received funding from the European Research Council under the European Union’s Seventh Framework Program (FP7/2007-2013) including ERC grant agreements 240672, 291329, and 306478. We acknowledge support from the Brazilian Instituto Nacional de Ciência e Tecnologia (INCT) e-Universe (CNPq grant 465376/2014-2). Parts of this research were supported by the Australian Research Council under grants DP160100930, FL180100168, and FT140101270