The bacillary and macrophage response to hypoxia in tuberculosis and the consequences for T cell antigen recognition

M. tuberculosis is a facultative anaerobe and its characteristic pathological hallmark, the granuloma, exhibits hypoxia in humans and in most experimental models. Thus the host and bacillary adaptation to hypoxia is of central importance in understanding pathogenesis and thereby to derive new drug treatments and vaccines

The answers are within me. An evaluation of a person centred counselling service for men at HMP Doncaster who have had experience of domestic violence 2005-2007

This report is the second year evaluation of the person centred counselling service for male victims and perpetrators of domestic violence at HMP Doncaster in 2006/7. This report follows on from the previous year's evaluation, Raging Anger Within Me, which evaluated this project in 2005/6. Initiated by the Doncaster Rape and Sexual Abuse Counselling Centre (DRSACC), the second year of counselling service delivery was also funded by Lloyds TSB and the Tudor Trust. The report provides a background to the service offered, details the key factors in the service's success and makes recommendations for the future sustainability of this innovative service. The report also contains a particularly interesting section detailing how the appropriateness of the service is perceived by experienced prison staff

NICMOS and VLBA observations of the gravitational lens system B1933+503

NICMOS observations of the complex gravitational lens system B1933+503 reveal infrared counterparts to two of the inverted spectrum radio images. The infrared images have arc-like structures. The corresponding radio images are also detected in a VLBA map made at 1.7 GHz with a resolution of 6 mas. We fail to detect two of the four inverted radio spectrum components with the VLBA even though they are clearly visible in a MERLIN map at the same frequency at a different epoch. The absence of these two components could be due to rapid variability on a time-scale less than the time delay, or to broadening of the images during propagation of the radio waves through the ISM of the lensing galaxy to an extent that they fall below the surface brightness detectability threshold of the VLBA observations. The failure to detect the same two images with NICMOS is probably due to extinction in the ISM of the lensing galaxy.Comment: 5 pages, 4 figures, submitted to MNRA

Assessment of treatment response in tuberculosis

Antibiotic treatment of tuberculosis has a duration of several months. There is significant variability of the host immune response and the pharmacokinetic-pharmacodynamic properties of Mycobacterium tuberculosis sub-populations at the site of disease. A limitation of sputum-based measures of treatment response may be sub-optimal detection and monitoring of Mycobacterium tuberculosis sub-populations. Potential biomarkers and surrogate endpoints should be benchmarked against hard clinical outcomes (failure/relapse/death) and may need tailoring to specific patient populations. Here, we assess the evidence supporting currently utilized and future potential host and pathogen-based models and biomarkers for monitoring treatment response in active and latent tuberculosis. Biomarkers for monitoring treatment response in extrapulmonary, pediatric and drug resistant tuberculosis are research priorities

Study of Apollo water impact. Volume 6 - User's manual - Interaction Final report

Computer program for hydroelastic responses of flexible shells of revolution during axially symmetric impact into incompressible fluids as in Apollo water impac

NASTRAN used in a production environment

A finite element analysis procedure built around the NASTRAN system is assessed. A number of support programs that were either written or modified to interface with NASTRAN and some improvements that were made to NASTRAN itself are noted. Some typical models are analyzed and an actual schedule is followed for constructing and analyzing the models to support a large design program

Ergodic and non-ergodic clustering of inertial particles

We compute the fractal dimension of clusters of inertial particles in mixing flows at finite values of Kubo (Ku) and Stokes (St) numbers, by a new series expansion in Ku. At small St, the theory includes clustering by Maxey's non-ergodic 'centrifuge' effect. In the limit of St to infinity and Ku to zero (so that Ku^2 St remains finite) it explains clustering in terms of ergodic 'multiplicative amplification'. In this limit, the theory is consistent with the asymptotic perturbation series in [Duncan et al., Phys. Rev. Lett. 95 (2005) 240602]. The new theory allows to analyse how the two clustering mechanisms compete at finite values of St and Ku. For particles suspended in two-dimensional random Gaussian incompressible flows, the theory yields excellent results for Ku < 0.2 for arbitrary values of St; the ergodic mechanism is found to contribute significantly unless St is very small. For higher values of Ku the new series is likely to require resummation. But numerical simulations show that for Ku ~ St ~ 1 too, ergodic 'multiplicative amplification' makes a substantial contribution to the observed clustering.Comment: 4 pages, 2 figure

The N-steps Invasion Percolation Model

A new kind of invasion percolation is introduced in order to take into account the inertia of the invader fluid. The inertia strength is controlled by the number N of pores (or steps) invaded after the perimeter rupture. The new model belongs to a different class of universality with the fractal dimensions of the percolating clusters depending on N. A blocking phenomenon takes place in two dimensions. It imposes an upper bound value on N. For pore sizes larger than the critical threshold, the acceptance profile exhibits a permanent tail.Comment: LaTeX file, 12 pages, 5 ps figures, to appear in Physica

Adiabatic theorem for non-hermitian time-dependent open systems

In the conventional quantum mechanics (i.e., hermitian QM) the adia- batic theorem for systems subjected to time periodic fields holds only for bound systems and not for open ones (where ionization and dissociation take place) [D. W. Hone, R. Ketzmerik, and W. Kohn, Phys. Rev. A 56, 4045 (1997)]. Here with the help of the (t,t') formalism combined with the complex scaling method we derive an adiabatic theorem for open systems and provide an analytical criteria for the validity of the adiabatic limit. The use of the complex scaling transformation plays a key role in our derivation. As a numerical example we apply the adiabatic theorem we derived to a 1D model Hamiltonian of Xe atom which interacts with strong, monochromatic sine-square laser pulses. We show that the gener- ation of odd-order harmonics and the absence of hyper-Raman lines, even when the pulses are extremely short, can be explained with the help of the adiabatic theorem we derived