1,023 research outputs found

    Exact norm-conserving stochastic time-dependent Hartree-Fock

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    We derive an exact single-body decomposition of the time-dependent Schroedinger equation for N pairwise-interacting fermions. Each fermion obeys a stochastic time-dependent norm-preserving wave equation. As a first test of the method we calculate the low energy spectrum of Helium. An extension of the method to bosons is outlined.Comment: 21 pages, 3 figures, LaTeX fil

    Numerical Methods for Stochastic Differential Equations

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    Stochastic differential equations (sdes) play an important role in physics but existing numerical methods for solving such equations are of low accuracy and poor stability. A general strategy for developing accurate and efficient schemes for solving stochastic equations in outlined here. High order numerical methods are developed for integration of stochastic differential equations with strong solutions. We demonstrate the accuracy of the resulting integration schemes by computing the errors in approximate solutions for sdes which have known exact solutions

    Diverse and productive source of biopolymer inspiration: marine collagens

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    Marine biodiversity is expressed through the huge variety of vertebrate and invertebrate species inhabiting intertidal to deep-sea environments. The extraordinary variety of â forms and functionsâ  exhibited by marine animals suggests they are a promising source of bioactive molecules and provides potential inspiration for different biomimetic approaches. This diversity is familiar to biologists and has led to intensive investigation of metabolites, polysaccharides, and other compounds. However, marine collagens are less well-known. This review will provide detailed insight into the diversity of collagens present in marine species in terms of their genetics, structure, properties, and physiology. In the last part of the review the focus will be on the most common marine collagen sources and on the latest advances in the development of innovative materials exploiting, or inspired by, marine collagens.The authors are grateful for the financial support from European Union, under the scope of European Regional Development Fund((ERDF) through the POCTEP project 0687_NOVOMAR_1_P and Structured Project NORTE-01- 0145-FEDER-000021 and from the Portuguese Foundation for Science and Technology (FCT), under the scope of the BiogenInk project (M-ERA-NET2/0022/2016) and from the European Cooperation in Science & Technology program (EU COST). Grant title: “Stem cells of marine/aquatic inverte brates: from basic research to innovative applications” (MARISTEM). MSR acknowledges FCT for the Ph.D. scholarship (PD/BD/143091/2018)

    Σύνθεση ιοντικών υγρών και βαθέων ευτηκτικών διαλυτών και εφαρμογή τους στο διαχωρισμό του αζεοτροπικού μίγματος αιθανόλης/νερού

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    Productivity in temperate tree crops such as apple has been lifted several-fold by research focusing on optimising a combination of canopy components including light relations, vigour control, tree architecture and crop load. This paper outlines the research behind the Small Tree-High Productivity Initiative (STHPI), which is focused on improving productivity of mango, avocado and macadamia. Preliminary results from work we are undertaking for each of the above canopy components in mango will be outlined. A rootstock screening trial to identify vigour-managing, high-productivity rootstocks is being undertaken, and we present a comparison of the best-performing low-medium vigour rootstock varieties compared with control 'Kensington Pride' (KP) rootstock at 6 months old. Comparisons between 'Keitt', 'NMBP 1243' and 'Calypso' scion cultivars with regard to tree diameter, height and canopy growth at different orchard densities and training systems will also be presented. Preliminary results from an orchard light-relations study indicate that mango yields continued to increase with light interception up to 50%, and reached a maximum of 20-30 t ha at 68% light interception in KP trees approximately 25 years old. In a crop load trial, inflorescence thinning in a 'Calypso' orchard did not significantly reduce yields when up to 90% of inflorescences were removed, but did when 95% of inflorescences were removed, as trees were unable to compensate by adjusting fruit set, size and yield. Inflorescence thinning beyond 80% increased the number of fruit set per panicle, and thinning up to and including 90% of inflorescences increased fruit weight from 340 g to >400 g per fruit. This project is still in its initial stages; however, early indications suggest there may be opportunities to improve early orchard yields through optimising light interception in an orchard's life, potentially through the use of higher densities, and that rootstocks and tree training methods, once identified, may help in the management of vigour. It is also hoped to obtain a better understanding of how crop load influences the balance between vegetative growth, flowering, fruiting, alternate bearing and fruit quality

    Exponential Divergence and Long Time Relaxation in Chaotic Quantum Dynamics

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    Phase space representations of the dynamics of the quantal and classical cat map are used to explore quantum--classical correspondence in a K-system: as 0\hbar \to 0, the classical chaotic behavior is shown to emerge smoothly and exactly. The quantum dynamics near the classical limit displays both exponential separation of adjacent distributions and long time relaxation, two characteristic features of classical chaotic motion.Comment: 10 pages, ReVTeX, to appear in Phys. Rev. Lett. 13 figures NOT included. Available either as LARGE (uuencoded gzipped) postscript files or hard-copies from [email protected]

    First-principles quantum dynamics in interacting Bose gases I: The positive P representation

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    The performance of the positive P phase-space representation for exact many-body quantum dynamics is investigated. Gases of interacting bosons are considered, where the full quantum equations to simulate are of a Gross-Pitaevskii form with added Gaussian noise. This method gives tractable simulations of many-body systems because the number of variables scales linearly with the spatial lattice size. An expression for the useful simulation time is obtained, and checked in numerical simulations. The dynamics of first-, second- and third-order spatial correlations are calculated for a uniform interacting 1D Bose gas subjected to a change in scattering length. Propagation of correlations is seen. A comparison is made to other recent methods. The positive P method is particularly well suited to open systems as no conservation laws are hard-wired into the calculation. It also differs from most other recent approaches in that there is no truncation of any kind.Comment: 21 pages, 7 figures, 2 tables, IOP styl

    Molecular architecture of Gαo and the structural basis for RGS16-mediated deactivation

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    Heterotrimeric G proteins relay extracellular cues from heptahelical transmembrane receptors to downstream effector molecules. Composed of an α subunit with intrinsic GTPase activity and a βγ heterodimer, the trimeric complex dissociates upon receptor-mediated nucleotide exchange on the α subunit, enabling each component to engage downstream effector targets for either activation or inhibition as dictated in a particular pathway. To mitigate excessive effector engagement and concomitant signal transmission, the Gα subunit's intrinsic activation timer (the rate of GTP hydrolysis) is regulated spatially and temporally by a class of GTPase accelerating proteins (GAPs) known as the regulator of G protein signaling (RGS) family. The array of G protein-coupled receptors, Gα subunits, RGS proteins and downstream effectors in mammalian systems is vast. Understanding the molecular determinants of specificity is critical for a comprehensive mapping of the G protein system. Here, we present the 2.9 Å crystal structure of the enigmatic, neuronal G protein Gαo in the GTP hydrolytic transition state, complexed with RGS16. Comparison with the 1.89 Å structure of apo-RGS16, also presented here, reveals plasticity upon Gαo binding, the determinants for GAP activity, and the structurally unique features of Gαo that likely distinguish it physiologically from other members of the larger Gαi family, affording insight to receptor, GAP and effector specificity

    Ethical issues in the use of in-depth interviews: literature review and discussion

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    This paper reports a literature review on the topic of ethical issues in in-depth interviews. The review returned three types of article: general discussion, issues in particular studies, and studies of interview-based research ethics. Whilst many of the issues discussed in these articles are generic to research ethics, such as confidentiality, they often had particular manifestations in this type of research. For example, privacy was a significant problem as interviews sometimes probe unexpected areas. For similar reasons, it is difficult to give full information of the nature of a particular interview at the outset, hence informed consent is problematic. Where a pair is interviewed (such as carer and cared-for) there are major difficulties in maintaining confidentiality and protecting privacy. The potential for interviews to harm participants emotionally is noted in some papers, although this is often set against potential therapeutic benefit. As well as these generic issues, there are some ethical issues fairly specific to in-depth interviews. The problem of dual role is noted in many papers. It can take many forms: an interviewer might be nurse and researcher, scientist and counsellor, or reporter and evangelist. There are other specific issues such as taking sides in an interview, and protecting vulnerable groups. Little specific study of the ethics of in-depth interviews has taken place. However, that which has shows some important findings. For example, one study shows participants are not averse to discussing painful issues provided they feel the study is worthwhile. Some papers make recommendations for researchers. One such is that they should consider using a model of continuous (or process) consent rather than viewing consent as occurring once, at signature, prior to the interview. However, there is a need for further study of this area, both philosophical and empirical

    Can we avoid high coupling?

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    It is considered good software design practice to organize source code into modules and to favour within-module connections (cohesion) over between-module connections (coupling), leading to the oft-repeated maxim "low coupling/high cohesion". Prior research into network theory and its application to software systems has found evidence that many important properties in real software systems exhibit approximately scale-free structure, including coupling; researchers have claimed that such scale-free structures are ubiquitous. This implies that high coupling must be unavoidable, statistically speaking, apparently contradicting standard ideas about software structure. We present a model that leads to the simple predictions that approximately scale-free structures ought to arise both for between-module connectivity and overall connectivity, and not as the result of poor design or optimization shortcuts. These predictions are borne out by our large-scale empirical study. Hence we conclude that high coupling is not avoidable--and that this is in fact quite reasonable

    Ultrastructural and biochemical characterization of mechanically adaptable collagenous structures in the edible sea urchin Paracentrotus lividus

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    The viscoelastic properties of vertebrate connective tissues rarely undergo significant changes withinphysiological timescales, the only major exception being the reversible destiffening of the mammalianuterine cervix at the end of pregnancy. In contrast to this, the connective tissues of echinoderms (seaurchins, starfish, sea cucumbers, etc.) can switch reversibly between stiff and compliant conditions intimescales of around a second to minutes. Elucidation of the molecular mechanism underlying suchmutability has implications for the zoological, ecological and evolutionary field. Important informationcould also arise for veterinary and biomedical sciences, particularly regarding the pathological plasti-cization or stiffening of connective tissue structures. In the present investigation we analyzed aspectsof the ultrastructure and biochemistry in two representative models, the compass depressor ligamentand the peristomial membrane of the edible sea urchin Paracentrotus lividus, compared in three differentmechanical states. The results provide further evidence that the mechanical adaptability of echinodermconnective tissues does not necessarily imply changes in the collagen fibrils themselves. The higher gly-cosaminoglycan (GAG) content registered in the peristomial membrane with respect to the compassdepressor ligament suggests a diverse role of these molecules in the two mutable collagenous tissues.The possible involvement of GAG in the mutability phenomenon will need further clarification. Duringthe shift from a compliant to a standard condition, significant changes in GAG content were detected onlyin the compass depressor ligament. Similarities in terms of ultrastructure (collagen fibrillar assembling)and biochemistry (two alpha chains) were found between the two models and mammalian collagen.Nevertheless, differences in collagen immunoreactivity, alpha chain migration on SDS-PAGE and BLASTalignment highlighted the uniqueness of sea urchin collagen with respect to mammalian collagen
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