2,780 research outputs found
The Physiological Basis for Altered Na\u3csup\u3e+\u3c/sup\u3e and Cl\u3csup\u3e-\u3c/sup\u3e Movement Across the Gills of Rainbow Trout (\u3cem\u3eOncorhynchus mykiss\u3c/em\u3e) in Alkaline (pH=9.5) Water
To test the hypothesis that internal ion imbalances at high pH are caused by altered branchial ion transporting capacity and permeability, radiotracers (24Na+ and 36Cl-) were used to measure ion movements across the gills of intact rainbow trout (Oncorhynchus mykiss) during 3 d exposure to pH 9.5. At control pH (pH 8.0), the trout were in net ion balance, but by 8 h at high pH, 60%â70% reductions in Cl- influx (Cl) and Na+ influx (JNa/in) led to net Cl- and Na+ losses of -200 ”mol kg-1 h-1. Outflux (diffusive efflux plus renal ion losses) was not initially altered. By 72 h, net Cl- balance was reestablished because of a restoration of JCl/in. Although JNa/in remained 50% lower at this time, counterbalancing reductions in Na+ outflux restored net Na+ balance. One-substrate ion-uptake kinetics analyses indicated that reduced ion influx after 8 h at pH 9.5 was caused by 50% decreases in Cl- and Na+ maximal transport rates (JCl/max, JNa/max), likely reflecting decreased numbers of functional transport sites. Two-substrate kinetic analyses indicated that reduced internal HCO3- and H+ supply for respective branchial Cl-/base and Na+/acid transport systems also contributed to lower JCl/in and, to a lesser extent, lower JNa/in at pH 9.5. Recovery in in of JCl/in after 3 d accounted for restoration of Cl- balance and max likely reflected increased numbers of transport sites. In contrast, JNa/in remained 33% lower after 3 d, but a lower affinity of the max gills for Na+ (fourfold greater KNa/m) accounted for the chronic m reduction in Na+ influx at pH 9.5. Thus, reestablishment of Cl- uptake capacity and counterbalancing reductions in Na+ outflux allows rainbow trout to reestablish net ion balance in alkaline waters
A cascaded H-bridge BLDC drive incorporating battery management
A multilevel BLDC drive is proposed using cascaded H-bridges with isolated sources to provide superior output waveforms and reduced current ripple whilst incorporating observer based SoC estimation. Energy management, based on SoC, is incorporated to improve battery performance, reduce variation between cells and to control charge/discharge profiles
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Neural processing of imminent collision in humans
Detecting a looming object and its imminent collision is imperative to survival. For most humans, it is a fundamental aspect of daily activities such as driving, road crossing and participating in sport, yet little is known about how the brain both detects and responds to such stimuli. Here we use functional magnetic resonance imaging to assess neural response to looming stimuli in comparison with receding stimuli and motion-controlled static stimuli. We demonstrate for the first time that, in the human, the superior colliculus and the pulvinar nucleus of the thalamus respond to looming in addition to cortical regions associated with motor preparation. We also implicate the anterior insula in making timing computations for collision events
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An fMRI study of parietal cortex involvement in the visual guidance of locomotion
Locomoting through the environment typically involves anticipating impending changes in heading trajectory in addition to maintaining the current direction of travel. We explored the neural systems involved in the âfar roadâ and ânear roadâ mechanisms proposed by Land and Horwood (1995) using simulated forward or backward travel where participants were required to gauge their current direction of travel (rather than directly control it). During forward egomotion, the distant road edges provided future path information, which participants used to improve their heading judgments. During backward egomotion, the road edges did not enhance performance because they no longer provided prospective information. This behavioral dissociation was reflected at the neural level, where only simulated forward travel increased activation in a region of the superior parietal lobe and the medial intraparietal sulcus. Providing only near road information during a forward heading judgment task resulted in activation in the motion complex. We propose a complementary role for the posterior parietal cortex and motion complex in detecting future path information and maintaining current lane positioning, respectively. (PsycINFO Database Record (c) 2010 APA, all rights reserved
Hardware-in-the-loop tuning of a feedback controller for a buck converter using a GA
This paper presents a methodology for tuning a PID-based feedback controller for a buck converter using the ITAE controller performance index. The controller parameters are optimized to ensure that a reasonable transient response can be achieved whilst retaining stable operation. Experimental results demonstrate the versatility of the on-line tuning methodology
Peritonitis. Some experimental and clinical observations on its pathology, prophylaxis and treatment
The impression conveyed to one from a
rapid survey of the vast literature 011 the subject
of Peritonitis is that this literature may be
divided into two clearly defined and widely differing
parts.
The one part dealing with the experimental
side of the subject,is chiefly concerned with
physiological and pathological questions,and to a
less degree with prophylactic measures for peritonltis;
this part is highly scientific in its methods and design.
The other part deals with the methods and
the results of the surgical treatment of Peritonitis
practised in various hospitals and this section
bears for the most part singularly little relation
to the former one.
This separation and lack of co-operation
between the experimental and the clinical workers
on the subject has, one feels sure, retarded the
progress of our treatment of Peritonitis.
The work recorded in this thesis is an
attempt to harmonise and to combine the methods of
experimental research with those of clinical and
practical therapeutics. Whilst this thesis treats
essentially of the use of certain prophylactic and
therapeutic measures for peritoneal infections,
facts of a more purely pathological and bacteriological
nature which were brought out during the
research are ,however,also recorded and discussed
Rapid Metabolic Recovery Following Vigorous Exercise in Burrow-Dwelling Larval Sea Lampreys (\u3cem\u3ePetromyzon marinus\u3c/em\u3e)
Although the majority of the sea lampreyâs (Petromyzon marinus) life cycle is spent as a burrow-dwelling larva, or ammocoete, surprisingly little is known about intermediary metabolism in this stage of the lampreyâs life history. In this study, larval sea lampreys (ammocoetes) were vigorously exercised for 5 min, and their patterns of metabolic fuel depletion and replenishment and oxygen consumption, along with measurements of net whole-body acid and ion movements, were followed during a 4â24-h postexercise recovery period. Exercise led to initial five- to sixfold increases in postexercise oxygen consumption, which remained significantly elevated by 1.5â2.0 times for the next 3 h. Exercise also led to initial 55% drops in whole-body phosphocreatine, which was restored by 0.5 h, but no significant changes in whole-body adenosine triphosphate were observed. Whole-body glycogen concentrations dropped by 70% immediately following exercise and were accompanied by a simultaneous ninefold increase in lactate. Glycogen and lactate were quickly restored to resting levels after 0.5 and 2.0 h, respectively. The presence of an associated metabolic acidosis was supported by very high rates of metabolic acid excretion, which approached 1,000 nmol g-1 during the first 2 h of postexercise recovery. Exercise-induced ion imbalances were also rapidly alleviated, as initially high rates of net Na+ and Cl- loss (â1,200 nmol g-1h-1 and â1,800 nmol g-1h-1 respectively) were corrected within 1â2 h. Although larval sea lampreys spend most of their time burrowed, they are adept at performing and recovering from vigorous anaerobic exercise. Such attributes could be important when these animals are vigorously swimming or burrowing as they evade predators or forage
Numerical Methods for Stochastic Differential Equations
Stochastic differential equations (sdes) play an important role in physics
but existing numerical methods for solving such equations are of low accuracy
and poor stability. A general strategy for developing accurate and efficient
schemes for solving stochastic equations in outlined here. High order numerical
methods are developed for integration of stochastic differential equations with
strong solutions. We demonstrate the accuracy of the resulting integration
schemes by computing the errors in approximate solutions for sdes which have
known exact solutions
The Effect of Natural Dissolved Organic Carbon on the Acute Toxicity of Copper to Larval Freshwater Mussels (\u3cem\u3eGlochidia\u3c/em\u3e)
The present study examined the effect of dissolved organic carbon (DOC), both added and inherent, on Cu toxicity in glochidia, the larvae of freshwater mussels. Using incremental additions of natural DOC concentrate and reconstituted water, a series of acute copper toxicity tests were conducted. An increase in DOC from 0.7 to 4.4 mg C/L resulted in a fourfold increase (36â150 ÎŒg Cu/L) in the 24-h median effective concentration (EC50) and a significant linear relationship (r2=0.98, p=0.0008) between the DOC concentration and the Cu EC50 of Lampsilis siliquoidea glochidia. The ameliorating effect of added DOC on Cu toxicity was confirmed using a second mussel species, the endangered (in Canada) Lampsilis fasciola. The effect of inherent (i.e., not added) DOC on Cu toxicity was also assessed in eight natural waters (DOC 5â15 mg C/L). These experiments revealed a significant relationship between the EC50 and the concentration of inherent DOC (r2=0.79, p=0.0031) with EC50s ranging from 27 to 111 ÎŒg Cu/L. These laboratory tests have demonstrated that DOC provides glochidia with significant protection from acute Cu toxicity. The potential risk that Cu poses to mussel populations was assessed by comparing Cu and DOC concentrations from significant mussel habitats in Ontario to the EC50s. Although overall mean Cu concentration in the musselâs habitat was well below the acutely toxic level given the concentration of DOC, episodic Cu releases in low DOC waters may be a concern for the recovery of endangered freshwater mussels. The results are examined in the context of current Cu water quality regulations including the U.S. Environmental Protection Agencyâs (U.S. EPA) biotic ligand model
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