The timing of maternal depressive symptoms and child cognitive development: a longitudinal study.

Background: Maternal depression is known to be associated with impairments in child cognitive development, although the effect of timing of exposure to maternal depression is unclear. Methods: Data collected for the Avon Longitudinal Study of Parents and Children, a longitudinal study beginning in pregnancy, included self-report measures of maternal depression the Edinburgh Postnatal Depression Scale, completed on 6 occasions up to 3 years of age, and IQ of the index child (WISC) measured at aged 8 years. We used these data to assign women to 8 groups according to whether depression occurred in the antenatal, postnatal, preschool period, any combination of these times, or not at all. We compared a model comprising all patterns of depression (saturated model) with models nested within this to test whether there is a relationship between depression and child cognitive development and, if so, whether there is a sensitive period. We then investigated the relationship with child IQ for each model, following adjustment for confounders. Results: Six thousand seven hundred and thirty-five of 13,615 children from singleton births (49.5%, of eligible core sample) attended a research clinic at 8 years and completed a WISC with a score ≥ 70. A total of 5,029 mothers of these children had completed mood assessments over the 3 time periods. In unadjusted analyses, all three sensitive period models were as good as the saturated model, as was an accumulation model. Of the sensitive period models, only that for antenatal exposure was a consistently better fit than the accumulation model. After multiple imputation for missing data (to n = 6,735), there was no effect of postnatal depression on child IQ independent of depression at other times [-0.19 IQ points, 95% confidence interval (CI) -1.5 to 1.1 points]. There was an effect of antenatal depression (-3.19 IQ points, 95% CI: -4.33 to -2.06) which attenuated following adjustment (-0.64 IQ points, 95% CI: -1.68 to 0.40). Conclusions: The postnatal period is not a sensitive one for the effect of maternal depression on child cognitive development. © 2011 The Authors. Journal of Child Psychology and Psychiatry

The effects of isometric exercise training on femoral and brachial artery dimension and blood flow in middle-aged men.

Introduction Previous isometric training studies reporting reductions in resting blood pressure have not explored whether there are concomitant changes in resting artery dimensions and blood flow. Furthermore, the influence of isometric training intensity on these adaptations has not been investigated. Therefore, the purpose of this study was to explore whether training-induced reductions in resting blood pressure are associated with concomitant changes in the vasculature of the trained and untrained limbs and to establish if these adaptations were intensity dependent. Methods Subjects undertook an 8 week training programme consisting of 4x2 min bilateral-leg isometric contractions 3 x per week (Wiles et al., 2010). Two groups exercised at intensities equivalent to 70% (n=10) or 85% (n=10) of their peak heart rate (%HRpeak; as established in a prior incremental test), and a third group acted as controls (n=10). Resting systolic (SBP), mean arterial (MAP) and diastolic (DBP) blood pressure was measured at baseline and post-training. Artery diameter and mean blood flow (brachial and femoral) were also measured at rest using Doppler ultrasound. Analysis of variance was used to determine whether post-training measures were significantly different to baseline. Also, baseline values were used as a covariate to account for initial resting blood pressure values. Results There were significant reductions in resting SBP (-10.8±7.9 mmHg) and MAP (-4.7±6.8 mmHg) in the 85%T group post-training and concomitant significant increases in resting femoral mean artery diameter (FMAD; 1.0±0.4 mm) and femoral mean blood velocity (FMBV; 0.68±0.83 cm/s), which resulted in increased femoral artery blood flow (FABF; 82.06±31.92 ml/min). There were no significant changes in brachial artery measures after training. Furthermore, there were no significant changes in any resting measure in the 70%T or control group. Discussion This study shows that the reductions in resting SBP and MAP observed after isometric training are associated with concomitant increases in resting artery dimensions and blood flow, but these changes were restricted to the trained limbs. This suggests that the vascular adaptations were localised. Furthermore, these adaptations seem to be training-intensity dependent, as they were not observed in the 70%T training group. These findings could be explained by reduced resting vascular tone, enhanced endothelium-dependent function or by vascular remodelling. The stimulus for such adaptations may arise from changes in availability/activity of nitric oxide as a result of sheer stresses during isometric exercise (McGowan et al. 2007). Exactly how these sheer stresses occur during isometric exercise and how they might be related to isometric training intensity would be deserving of future study. McGowan CL, Levy AS, McCartney N, MacDonald MJ. (2007). Clin. Sci. 112, 403-409. Wiles JD, Coleman DA, Swaine IL. (2010). Eur. J. Appl. Physiol. 108, 419-428

K-Rational D-Brane Crystals

In this paper the problem of constructing spacetime from string theory is addressed in the context of D-brane physics. It is suggested that the knowledge of discrete configurations of D-branes is sufficient to reconstruct the motivic building blocks of certain Calabi-Yau varieties. The collections of D-branes involved have algebraic base points, leading to the notion of K-arithmetic D-crystals for algebraic number fields K. This idea can be tested for D0-branes in the framework of toroidal compactifications via the conjectures of Birch and Swinnerton-Dyer. For the special class of D0-crystals of Heegner type these conjectures can be interpreted as formulae that relate the canonical Neron-Tate height of the base points of the D-crystals to special values of the motivic L-function at the central point. In simple cases the knowledge of the D-crystals of Heegner type suffices to uniquely determine the geometry.Comment: 36 page

Individuals' Long Term Use of Cognitive Behavioural Skills to Manage their Depression: A Qualitative Study

Background: Cognitive Behavioural Therapy (CBT) aims to teach people skills to help them self-manage their depression. Trial evidence shows that CBT is an effective treatment for depression and individuals may experience benefits long-term. However, there is little research about individuals’ continued use of CBT skills once treatment has finished. Aims: To explore whether individuals who had attended at least 12 sessions of CBT continued to use and value the CBT skills they had learnt during therapy. Method: Semi-structured interviews were held with participants from the CoBalT trial who had received CBT, approximately 4 years earlier. Interviews were audio-recorded, transcribed and analysed thematically. Results: 20 participants were interviewed. Analysis of the interviews suggested that individuals who viewed CBT as a learning process, at the time of treatment, recalled and used specific skills to manage their depression once treatment had finished. In contrast, individuals who viewed CBT only as an opportunity to talk about their problems did not appear to utilize any of the CBT skills they had been taught and reported struggling to manage their depression once treatment had ended. Conclusions: Our findings suggest individuals may value and use CBT skills if they engage with CBT as a learning opportunity at the time of treatment. Our findings underline the importance of the educational model in CBT and the need to emphasize this to individuals receiving treatment

Ethical issues in the use of in-depth interviews: literature review and discussion

This paper reports a literature review on the topic of ethical issues in in-depth interviews. The review returned three types of article: general discussion, issues in particular studies, and studies of interview-based research ethics. Whilst many of the issues discussed in these articles are generic to research ethics, such as confidentiality, they often had particular manifestations in this type of research. For example, privacy was a significant problem as interviews sometimes probe unexpected areas. For similar reasons, it is difficult to give full information of the nature of a particular interview at the outset, hence informed consent is problematic. Where a pair is interviewed (such as carer and cared-for) there are major difficulties in maintaining confidentiality and protecting privacy. The potential for interviews to harm participants emotionally is noted in some papers, although this is often set against potential therapeutic benefit. As well as these generic issues, there are some ethical issues fairly specific to in-depth interviews. The problem of dual role is noted in many papers. It can take many forms: an interviewer might be nurse and researcher, scientist and counsellor, or reporter and evangelist. There are other specific issues such as taking sides in an interview, and protecting vulnerable groups. Little specific study of the ethics of in-depth interviews has taken place. However, that which has shows some important findings. For example, one study shows participants are not averse to discussing painful issues provided they feel the study is worthwhile. Some papers make recommendations for researchers. One such is that they should consider using a model of continuous (or process) consent rather than viewing consent as occurring once, at signature, prior to the interview. However, there is a need for further study of this area, both philosophical and empirical

Elliptic Curves over Real Quadratic Fields are Modular

We prove that all elliptic curves defined over real quadratic fields are modular.Comment: 38 pages. Magma scripts available as ancillary files with this arXiv versio

Modular symbols in Iwasawa theory

This survey paper is focused on a connection between the geometry of $\mathrm{GL}_d$ and the arithmetic of $\mathrm{GL}_{d-1}$ over global fields, for integers $d \ge 2$. For $d = 2$ over $\mathbb{Q}$, there is an explicit conjecture of the third author relating the geometry of modular curves and the arithmetic of cyclotomic fields, and it is proven in many instances by the work of the first two authors. The paper is divided into three parts: in the first, we explain the conjecture of the third author and the main result of the first two authors on it. In the second, we explain an analogous conjecture and result for $d = 2$ over $\mathbb{F}_q(t)$. In the third, we pose questions for general $d$ over the rationals, imaginary quadratic fields, and global function fields.Comment: 43 page

Information needs after stroke: What to include and how to structure it on a website. A qualitative study using focus groups and card sorting

Background: Use of the Internet to obtain health and other information is increasing. Previous studies have identified the specific information needs of people with stroke but not in relation to the Internet. People with aphasia (PwA) may face barriers in accessing the Internet: Navigating websites requires an ability to categorise information and this ability is often impaired in PwA. The website categorisation preferences of people with stroke and with aphasia have not yet been reported. Aims: This study aimed: (a) to determine what information people who have had a stroke would like to see on a website about living with stroke; (b) to determine the most effective means of structuring information on the website so that it is accessible to people with stroke; and c) to identify any differences between people with and without aphasia in terms of preferences for structuring information on the website. Methods & Procedures: Participants were recruited from a hospital's Stroke Database. Focus groups were used to elicit what information participants wanted on a website about living with stroke. The themes raised were depicted on 133 cards. To determine the most effective way of structuring information on the website, and whether there were any differences in preferences between PwA and PwoA, participants used a modified closed card-sorting technique to sort the cards under website categories. Outcomes & Results: A total of 48 people were invited, and 12 (25%) agreed to take part. We ran three focus groups: one with PwA (n = 5) and two with people without aphasia (PwoA) (n = 3, n = 4). Participants wanted more information about stroke causes and effects (particularly emotional issues), roles of local agencies, and returning to previous activities (driving, going out). All participants completed the card-sorting exercise. Few cards (6%) were categorised identically by everyone. Cards relating to local agencies and groups were not consistently categorised together. Cards relating to emotions were segregated. The categorisation preferences for PwA were more fragmented than those for PwoA: 60% of PwA agreed on the categorisation of 51% of the cards, whereas 60% of PwoA agreed on the categorisation of 76% of the cards. Conclusions: Information needs covered all stages of the stroke journey. The card sorting was accessible to everyone, and provided evidence of structuring preferences and of some of the categorisation difficulties faced by PwA. More research is needed on what an accessible website looks like for PwA

A new foundational crisis in mathematics, is it really happening?

The article reconsiders the position of the foundations of mathematics after the discovery of HoTT. Discussion that this discovery has generated in the community of mathematicians, philosophers and computer scientists might indicate a new crisis in the foundation of mathematics. By examining the mathematical facts behind HoTT and their relation with the existing foundations, we conclude that the present crisis is not one. We reiterate a pluralist vision of the foundations of mathematics. The article contains a short survey of the mathematical and historical background needed to understand the main tenets of the foundational issues.Comment: Final versio