Jacobean Textile Design: Surviving (and Thriving) Through the Test of Time

Jacobean textile design sprang from the Tree of Life motif, an ancient design that carried religious symbolism for many early cultures. It represented a greater power and as such could provide protection and even fertility. When trade routes opened up between the East and West in the early 17th century, Europeans were eager for items made in the East and in particular for textiles from India embellished with The Tree of Life. This increase in trade provided a booming time for commerce. During the reign of James I in the early 1600’s, the English designers added their own creative touches to the Tree of Life, enhancing it with large, outrageous, exotic flowers, and highly designed leaves. Thus was born the Jacobean textile design. The textiles being imported into Europe from the East were expensive and therefore largely limited to the wealthy. As a result, textiles were often status symbols and considered to have considerable value, however, as technology advanced and textiles could be mass-produced more affordably, they became available to people of all economic groups. Over the years other artists, such as William Morris, have gained inspiration from the Jacobean textile design and made their own interpretations of it as well. Today, its complex arrangements of winding vines and fantasy flowers remain a popular design in home furnishings and other products

Asymmetric Bethe-Salpeter equation for pairing and condensation

The Martin-Schwinger hierarchy of correlations are reexamined and the three-particle correlations are investigated under various partial summations. Besides the known approximations of screened, ladder and maximally crossed diagrams the pair-pair correlations are considered. It is shown that the recently proposed asymmetric Bethe-Salpeter equation to avoid unphysical repeated collisions is derived as a result of the hierarchical dependencies of correlations. Exceeding the parquet approximation we show that an asymmetry appears in the selfconsistent propagators. This form is superior over the symmetric selfconsistent one since it provides the Nambu-Gorkov equations and gap equation for fermions and the Beliaev equations for bosons while from the symmetric form no gap equation results. The selfenergy diagrams which account for the subtraction of unphysical repeated collisions are derived from the pair-pair correlation in the three-particle Greenfunction. It is suggested to distinguish between two types of selfconsistency, the channel-dressed propagators and the completely dressed propagators, with the help of which the asymmetric expansion completes the Ward identity and is $\Phi$-derivable.Comment: 12 pages. 26 figure

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570