Evaluation of thermal insulation materials

Data was obtained on silicone-bonded fiberglass, isocyanurate foam, and two dozen other insulators. Materials were selected to withstand heat sterilization, outer space, and the Martian atmosphere. Significant environmental parameters were vibration, landing shock, and launch venting

Martian soft lander insulation study Final report

Martian soft lander insulation stud

Towards Open Access Publishing in High Energy Physics : Report of the SCOAP3 Working Party

This Report concerns the implementation of a process today supported by leading actors from the particle physics community, and worked through in detail by members of an international Working Party. The initiative offers an opportunity for the cost-effective dissemination of high-quality research articles in particle physics, enabling use of the new technologies of e-Science across the literature of High Energy physics

Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis

Switching to a glycolytic metabolism is a rapid adaptation of tumor cells to hypoxia. Although this metabolic conversion may primarily represent a rescue pathway to meet the bioenergetic and biosynthetic demands of proliferating tumor cells, it also creates a gradient of lactate that mirrors the gradient of oxygen in tumors. More than a metabolic waste, the lactate anion is known to participate to cancer aggressiveness, in part through activation of the hypoxia-inducible factor-1 (HIF-1) pathway in tumor cells. Whether lactate may also directly favor HIF-1 activation in endothelial cells (ECs) thereby offering a new druggable option to block angiogenesis is however an unanswered question. In this study, we therefore focused on the role in ECs of monocarboxylate transporter 1 (MCT1) that we previously identified to be the main facilitator of lactate uptake in cancer cells. We found that blockade of lactate influx into ECs led to inhibition of HIF-1-dependent angiogenesis. Our demonstration is based on the unprecedented characterization of lactate-induced HIF-1 activation in normoxic ECs and the consecutive increase in vascular endothelial growth factor receptor 2 (VEGFR2) and basic fibroblast growth factor (bFGF) expression. Furthermore, using a variety of functional assays including endothelial cell migration and tubulogenesis together with in vivo imaging of tumor angiogenesis through intravital microscopy and immunohistochemistry, we documented that MCT1 blockers could act as bona fide HIF-1 inhibitors leading to anti-angiogenic effects. Together with the previous demonstration of MCT1 being a key regulator of lactate exchange between tumor cells, the current study identifies MCT1 inhibition as a therapeutic modality combining antimetabolic and anti-angiogenic activities

Onderzoeksvoorstel Buijtenland van Rhoon

Rapport in opdracht van de Provincie Zuid-Holland. Ten zuiden van Rotterdam ontwikkelt de provincie Zuid?Holland een landschapspark van 600 hectare, het Buijtenland van Rhoon. Het belangrijkste doel van dit project is het verbeteren van de leefbaarheid in de regio. Tegelijkertijd met de keuze voor de aanleg van de tweede Maasvlakte is namelijk besloten dat behalve in de economie óók extra in leefbaarheid geïnvesteerd moet worden. Dit gegeven is de belangrijkste aanleiding om ten zuiden van Rotterdam, in de gemeente Albrandswaard, tussen Rhoon en de Oude Maas een aaneengesloten gebied van 600 hectare landbouwgebied om te vormen naar natuuren recreatiegebied ? met daarin ruimte voor agrarische bedrijvigheid. Veldacademie en Urban Landscape Architecture van de Technische Universiteit Delft zijn gevraagd een voorstel te doen om de ruimtelijke en maatschappelijke verbinding tussen het ‘nieuwe’ Buijtenland van Rhoon en haar omgeving in de komende jaren te versterken. Gezien de complexiteit van het vraagstuk is eerste stap een quickscan uitgevoerd, die in een discussiebijeenkomst is bediscussieerd. Ook zijn mogelijke partijen genoemd om mee samen te werken. Aan de hand van die input is dit voorstel opgezet.UrbanismArchitectur