Transitions to Proton States in the 90-Zr(p,p') Reaction at 160 MeV

This work was supported by National Science Foundation Grant PHY 76-84033 and Indiana Universit

Excitation of Neutron, Proton and Neutron-Hole States in the (p,p') Reaction at 160 MeV and 96 MeV

This work was supported by National Science Foundation Grant PHY 76-84033 and Indiana Universit

Systematics of Charged-Particle Products from Reactions Induced by 95-MeV 6-Li

This work was supported by National Science Foundation Grant PHY 76-84033 and Indiana Universit

Core Polarization Amplitudes for Single-Neutron-Hole Transitions Excited in the 207-Pb(p,p') Reaction at 135 MeV and 61 MeV

This work was supported by National Science Foundation Grants PHY 76-84033A01, PHY 78-22774, and Indiana Universit

Andronov-Hopf Bifurcations in Planar, Piecewise-Smooth, Continuous Flows

An equilibrium of a planar, piecewise-$C^1$, continuous system of differential equations that crosses a curve of discontinuity of the Jacobian of its vector field can undergo a number of discontinuous or border-crossing bifurcations. Here we prove that if the eigenvalues of the Jacobian limit to $\lambda_L \pm {\rm i} \omega_L$ on one side of the discontinuity and $-\lambda_R \pm {\rm i} \omega_R$ on the other, with $\lambda_L, \lambda_R >0$, and the quantity $\Lambda = \lambda_L / \omega_L -\lambda_R / \omega_R$ is nonzero, then a periodic orbit is created or destroyed as the equilibrium crosses the discontinuity. This bifurcation is analogous to the classical Andronov-Hopf bifurcation, and is supercritical if $\Lambda < 0$ and subcritical if $\Lambda >0$.Comment: laTex, 18 pages, 8 figure

Spin-Orbit Effects in the Excitation of Proton and Neutron States in the (p,p') Reaction at 160 MeV, 120 MeV, and 95 MeV

Supported by the National Science Foundation and Indiana Universit

Uniting cosmological epochs through the twister solution in cosmology with non-minimal coupling

We investigate dynamics of a flat FRW cosmological model with a barotropic matter and a non-minimally coupled scalar field (both canonical and phantom). In our approach we do not assume any specific form of a potential function for the scalar field and we are looking for generic scenarios of evolution. We show that dynamics of universe can be reduced to a 3-dimensional dynamical system. We have found the set of fixed points and established their character. These critical points represent all important epochs in evolution of the universe : (a) a finite scale factor singularity, (b) an inflation (rapid-roll and slow-roll), (c) a radiation domination, (d) a matter domination and (e) a quintessence era. We have shown that the inflation, the radiation and matter domination epochs are transient ones and last for a finite amount of time. The existence of the radiation domination epoch is purely the effect of a non-minimal coupling constant. We show the existence of a twister type solution wandering between all these critical points.Comment: 22 pages, 5 figs; (v2.) 27 pages, 12 figs, JCAP in pres

Large-scale pharmacogenomic study of sulfonylureas and the QT, JT and QRS intervals: CHARGE Pharmacogenomics Working Group

Sulfonylureas, a commonly used class of medication used to treat type 2 diabetes, have been associated with an increased risk of cardiovascular disease. Their effects on QT interval duration and related electrocardiographic phenotypes are potential mechanisms for this adverse effect. In 11 ethnically diverse cohorts that included 71 857 European, African-American and Hispanic/Latino ancestry individuals with repeated measures of medication use and electrocardiogram (ECG) measurements, we conducted a pharmacogenomic genome-wide association study of sulfonylurea use and three ECG phenotypes: QT, JT and QRS intervals. In ancestry-specific meta-analyses, eight novel pharmacogenomic loci met the threshold for genome-wide significance (P&lt;5 × 10−8), and a pharmacokinetic variant in CYP2C9 (rs1057910) that has been associated with sulfonylurea-related treatment effects and other adverse drug reactions in previous studies was replicated. Additional research is needed to replicate the novel findings and to understand their biological basis

Genome-wide meta-analysis of variant-by-diuretic interactions as modulators of lipid traits in persons of European and African ancestry

Hypertension (HTN) is a significant risk factor for cardiovascular morbidity and mortality. Metabolic abnormalities, including adverse cholesterol and triglycerides (TG) profiles, are frequent comorbid findings with HTN and contribute to cardiovascular disease. Diuretics, which are used to treat HTN and heart failure, have been associated with worsening of fasting lipid concentrations. Genome-wide meta-analyses with 39,710 European-ancestry (EA) individuals and 9925 African-ancestry (AA) individuals were performed to identify genetic variants that modify the effect of loop or thiazide diuretic use on blood lipid concentrations. Both longitudinal and cross sectional data were used to compute cohort-specific interaction results, which were then combined through meta-analysis in each ancestry. These ancestry-specific results were further combined through trans-ancestry meta-analysis. Analysis of EA data identified two genome-wide significant (p &lt; 5 × 10−8) loci with single nucleotide variant (SNV)-loop diuretic interaction on TG concentrations (including COL11A1). Analysis of AA data identified one genome-wide significant locus adjacent to BMP2 with SNV-loop diuretic interaction on TG concentrations. Trans-ancestry analysis strengthened evidence of association for SNV-loop diuretic interaction at two loci (KIAA1217 and BAALC). There were few significant SNV-thiazide diuretic interaction associations on TG concentrations and for either diuretic on cholesterol concentrations. Several promising loci were identified that may implicate biologic pathways that contribute to adverse metabolic side effects from diuretic therapy