295 research outputs found

    Epigenetic mechanisms of fine-tuning FKBP5 gene expression

    Get PDF

    Shear bond strength of brackets to demineralize enamel after different pretreatment methods

    Full text link
    Objective: To compare the influence of demineralized and variously pretreated demineralized enamel on the shear bond strength of orthodontic brackets. Materials and Methods: Sixty bovine enamel specimens were allocated to five groups (n  =  12). Specimens of group 1 were not demineralized and were not pretreated, but served as controls. The other specimens were demineralized to form artificial carious lesions. Samples from group 2 were only demineralized and were kept untreated in artificial saliva. The other samples were pretreated with highly concentrated fluoride preparations (group 3: Elmex Gelee, 1.23% F; group 4: Clinpro White Varnish, 2.23% F) or with an infiltrating resin (group 5: Icon). After respective pretreatments, brackets were adhesively fixed on all specimens with an adhesive system after etching with 35% phosphoric acid and application of a primer and bracket resin cement (Transbond XT). Bracket shear bond strength was evaluated with a universal testing machine. Statistical analysis was performed by one-way analysis of variance followed by a post-hoc Scheffé test. Results: Shear bond strength in control group 1 was statistically significantly greater compared with that in all other groups. Application of the infiltrating resin Icon (group 5) as pretreatment resulted in statistically significantly greater bond strength as compared with pretreatments with fluoride compounds (groups 3 and 4) and treatment provided without pretreatment (group 2). Groups 2, 3, and 4 did not significantly differ from each other. Conclusion: Pretreatment with the infiltrating resin is a beneficial approach to increasing the shear bond strength of brackets to demineralized enamel

    The effect of e-learning on the quality of orthodontic appliances

    Full text link
    Purpose: The effect of e-learning on practical skills in medicine has not yet been thoroughly investigated. Today’s multimedia learning environment and access to e-books provide students with more knowledge than ever before. The aim of this study is to evaluate the effect of online demonstrations concerning the quality of orthodontic appliances manufactured by undergraduate dental students. Materials and methods: The study design was a parallel-group randomized clinical trial. Fifty-four participants were randomly assigned to one of the three groups: 1) conventional lectures, 2) conventional lectures plus written online material, and 3) access to resources of groups one and two plus access to online video material. Three orthodontic appliances (Schwarz Plate, U-Bow Activator, and Fränkel Regulator) were manufactured during the course and scored by two independent raters blinded to the participants. A 15-point scale index was used to evaluate the outcome quality of the appliances. Results: In general, no significant differences were found between the groups. Concerning the appliances, the Schwarz Plate obtained the highest scores, whereas the Fränkel Regulator had the lowest scores; however, these results were independent of the groups. Females showed better outcome scores than males in groups two and three, but the difference was insignificant. Age of the participants also had no significant effect. Conclusion: The offer that students could use additional time and course-independent e-learning resources did not increase the outcome quality of the orthodontic appliances. The advantages of e-learning observed in the theoretical fields of medicine were not achieved in the educational procedures for manual skills. Factors other than e-learning may have a higher impact on manual skills, and this should be investigated in further studies

    Gender plays no role in student ability to perform on computer-based examinations

    Get PDF
    BACKGROUND: To see if there is a difference in performance when students switch from traditional paper-and-pencil examinations to computer-based examinations, and to determine whether there are gender differences in student performance in these two examination formats. METHODS: This study involved first year medical students at the University of Illinois at Urbana-Champaign over three Academic Years 2002–03/2003–04 and 2003–05. Comparisons of student performance by overall class and gender were made. Specific comparisons within courses that utilized both the paper-and-pencil and computer formats were analyzed. RESULTS: Overall performance scores for students among the various Academic Years revealed no differences between exams given in the traditional pen-and-paper and computer formats. Further, when we looked specifically for gender differences in performance between these two testing formats, we found none. CONCLUSION: The format for examinations in the courses analyzed does not affect student performance. We find no evidence for gender differences in performance on exams on pen-and-paper or computer-based exams

    High Throughput, Multiplexed Pathogen Detection Authenticates Plague Waves in Medieval Venice, Italy

    Get PDF
    Background: Historical records suggest that multiple burial sites from the 14th-16(th) centuries in Venice, Italy, were used during the Black Death and subsequent plague epidemics.Methodology/Principal Findings: High throughput, multiplexed real-time PCR detected DNA of seven highly transmissible pathogens in 173 dental pulp specimens collected from 46 graves. Bartonella quintana DNA was identified in five (2.9%) samples, including three from the 16th century and two from the 15th century, and Yersinia pestis DNA was detected in three (1.7%) samples, including two from the 14th century and one from the 16th century. Partial glpD gene sequencing indicated that the detected Y. pestis was the Orientalis biotype.Conclusions: These data document for the first time successive plague epidemics in the medieval European city where quarantine was first instituted in the 14th century

    Die Zukunft der Regionen in Nordrhein-Westfalen gestalten: Eine gemeinsame Aufgabe von Regionalplanung und Regionalentwicklung

    Get PDF
    In NRW haben sowohl die Regionalplanung als auch integrierte Ansätze der Regionalentwicklung, wie z.B. die REGIONALE NRW, eine lange Tradition. Das bisherige Nebeneinander soll im Sinne eines besseren Zusammenwirkens von Regionalplanung und Regionalentwicklung mit dem Ziel eines "guten Raumzustandes" überwunden werden. Elemente einer neuen Praxis könnten etwa ein "Brückendokument" (z.B. Raumbild) zur Vermittlung zwischen Regionalplanung und -entwicklung sowie eine eigenständig handlungsfähige organisatorische Verankerung des Prozessmanagements sein. Unabdingbar dafür sind eine entsprechende politische Legitimation und ein Wille zur regionalen Zusammenarbeit.In NRW, both regional planning and integrated approaches to regional development, such as the REGIONALE NRW, have a long tradition. These two fields have previously existed in parallel, a situation that should be overcome through the better interaction of regional planning and regional development with the goal of creating "good spatial conditions". Elements of a new practice approach could include a "bridging document" (e.g. spatial vision) to mediate between regional planning and development, and also independent, empowered and organisationally anchored process management. Indispensable here are the appropriate political legitimacy and a will for regional cooperation
    • …
    corecore