Synthetic Photoswitchable Neurotransmitters Based on Bridged Azobenzenes

Photoswitchable neurotransmitters of ionotropic kainate receptors were synthesized by tethering a glutamate moiety to disubstituted C2-bridged azobenzenes, which were prepared through a novel methodology that allows access to diazocines with higher yields and versatility. Because of the singular properties of these photochromes, photoisomerizable compounds were obtained with larger thermal stability for their inert cis isomer than for their biologically activity trans state. This enabled selective neuronal firing upon irradiation without background activity in the dark

A letter from Widukind ()

This is a letter from "Epistolae: Medieval Women's Letters". Epistolae is a collection of medieval Latin letters to and from women. The letters collected date from the 4th to the 13th centuries, and they are presented in their original Latin as well as in English translation. Dr. Joan Ferrante, Professor Emerita of English and Comparative Literature of Columbia University, has, with her colleagues, collected and translated these letters mainly from printed sources. She worked with the Columbia Center for New Media Teaching and Learning to develop this unique open online collection for teaching and research purposes

A letter from Widukind ()

This is a letter from "Epistolae: Medieval Women's Letters". Epistolae is a collection of medieval Latin letters to and from women. The letters collected date from the 4th to the 13th centuries, and they are presented in their original Latin as well as in English translation. Dr. Joan Ferrante, Professor Emerita of English and Comparative Literature of Columbia University, has, with her colleagues, collected and translated these letters mainly from printed sources. She worked with the Columbia Center for New Media Teaching and Learning to develop this unique open online collection for teaching and research purposes

A letter from Widukind ()

This is a letter from "Epistolae: Medieval Women's Letters". Epistolae is a collection of medieval Latin letters to and from women. The letters collected date from the 4th to the 13th centuries, and they are presented in their original Latin as well as in English translation. Dr. Joan Ferrante, Professor Emerita of English and Comparative Literature of Columbia University, has, with her colleagues, collected and translated these letters mainly from printed sources. She worked with the Columbia Center for New Media Teaching and Learning to develop this unique open online collection for teaching and research purposes

Synthese von funktionalisierten Diazocinen für die Photopharmakologie, Molekularbiologie und für responsive Materialien

The development of artificial photoswitches, which can change their configuration upon activation with light, has paved the way to numerous applications. These applications include drugs that can be activated in the affected tissue and no longer cause side effects elsewhere in the body, peptide cross-linkers, allowing the investigation of complex interactions in biological systems with high spatiotemporal resolution and stress sensing polymers. So far, many of the available artificial photoswitches were suffering from imperfect photophysical properties limiting their use in practical applications. To achieve this objective, improved systems are required, which overcome the systematic limitations of their predecessors. With high quantum yields and superior switching efficiency, diazocines have the potential to meet these requirements. One major advantage is the fact that already the parent system switches upon irradiation with visible light. The diazocine, often referred to as bridged azobenzene, in contrast to azobenzene is thermally stable in its cis configuration and should thus be suitable for photopharmacology and as a mechanophore in mechanoresponsive materials. Furthermore, it should be advantageous as a cross-linker for macromolecules, since its structure reduces hydrophobic interactions. To demonstrate the applicability of diazocines in a broad range of fields, it was essential to develop a synthesis strategy, allowing specific functionalization. The synthesis started from commercially or synthetically available 2 nitrotoluene derivatives. These were dimerized in an oxidative C-C coupling and subsequently converted either in reductive or oxidative azo cyclization reactions. In combination with a suitable protecting group strategy, several functional diazocines were synthesized and tested regarding their applicability in photopharmacology, molecular biology and materials science. In collaboration, diazocine-based synthetic neurotransmitters were synthesized and used to successfully activate and deactivate neuronal signaling and thereby prove the concept of diazocines in photopharmacology. Furthermore, it was shown that diazocines are suitable cross-linkers in both artificial and bio macromolecules

Historiae Tam Sacrae Quam Profanae Cognitio Et methodo & oratione utiliter pertractata

a Reinero Reineccio SteinhemioTitelaufl. der Ausg. Martinus Vogel & Johan Georg Täger, Helmstadii, 1660Vorlageform des Erscheinungsvermerks des beigef. Werks: Helmestadii, Excuderunt Martinus Vogel & Johan Georg Täger. Anno MDCLX.Beigef. Werk im Innern u.d.T.: Widechindi Magni, Regis Saxonum, Dynastae Angrivariorum, Et Illustriss. Stirpis Saxonicae, multarumq[ue] aliarum praepotentium familiarum, conditoris, effigies, insignia, versus epitaphi

Wittekindus Magnus

publicae luci expositus a Conrado Samuele SchurtzfleischGeschätztes Erscheinungsjahr aufgrund einer Druckvariante von 169

Jacobi Andreae Crusii ... Witikindus. Sive De Witikindi Principis Angariae, Ac Ducis Saxonum, Nec Non Libertatis Germanicae Diuturno Bello Contra Carolum Magnum Imperatorem Gesto Propugnatoris Fortissimi Vita, Moribus, Rebus Bello, Paceve Praeclare Gestis ... Liber Singularis : Ex Optimis Veterum Monumentis Concinnatus

Textteil auch in: Crusius, Christoph: Tractatus De Indiciis Delictorum, 1682Vorlageform des Erscheinungsvermerks: Mindae Sumptibus Jacobi Godefredi Seyler. Typis Joannis Pileri MDCLXXIX

Wie heeft Lahaut vermoord? De geheime Koude Oorlog in België.

Op 11 augustus 1950 wordt de eedaflegging van Koning Boudewijn door communisten verstoord met de beruchte kreet “Vive la République!”. Een week later wordt de populaire communistische partijleider, Julien Lahaut, voor zijn deur doodgeschoten. Het is de belangrijkste politieke moord in de Belgische geschiedenis, maar ze wordt nooit opgehelderd. Wie heeft Lahaut vermoord? werpt een kritische blik op het gerechtelijk onderzoek en gaat op zoek naar nieuwe sporen. Zo vonden de auteurs in een archief een ‘vergeten’ document dat verwijst naar André Moyen, een spion die een anticommunistisch netwerk uitbouwde in het naoorlogse België. Het boek bijt zich vast in de levensloop van Moyen en zijn ondergronds netwerk. De auteurs komen een web van leugens en fouten in het gerechtelijk onderzoek op het spoor. Ze leggen de redenen bloot waarom de moord nooit werd opgelost en plaatsen die in de ruimere context van de geheime Koude Oorlog in België