Open Charm and Beauty at Ultrarelativistic Heavy Ion Colliders

Important goals of RHIC and LHC experiments with ion beams include the creation and study of new forms of matter, such as the Quark Gluon Plasma. Heavy quark production and attenuation will provide unique tomographic probes of that matter. We predict the suppression pattern of open charm and beauty in $Au+Au$ collisions at RHIC and LHC energies based on the DGLV formalism of radiative energy loss. A cancelation between effects due to the $\sqrt{s}$ energy dependence of the high $p_T$ slope and heavy quark energy loss is predicted to lead to surprising similarity of heavy quark suppression at RHIC and LHC.Comment: 4 pages, 6 *.eps files combined into 4 figure

Open heavy flavor production at RHIC

The study of heavy flavor production in relativistic heavy ion collisions is an extreme experimental challenge but provides important information on the properties of the Quark-Gluon Plasma (QGP) created in Au+Au collisions at RHIC. Heavy-quarks are believed to be produced in the initial stages of the collision, and are essential on the understanding of parton energy loss in the dense medium created in such environment. Moreover, heavy-quarks can help to investigate fundamental properties of QCD in elementary p+p collisions. In this work we review recent results on heavy flavor production and their interaction with the hot and dense medium at RHIC.Comment: Quark Matter 2006 proceedings, 8 pages, 5 figure

High power diode laser Master Oscillator-Power Amplifier (MOPA)

High power multiple quantum well AlGaAs diode laser master oscillator - power amplifier (MOPA) systems were examined both experimentally and theoretically. For two pass operation, it was found that powers in excess of 0.3 W per 100 micrometers of facet length were achievable while maintaining diffraction-limited beam quality. Internal electrical-to-optical conversion efficiencies as high as 25 percent were observed at an internal amplifier gain of 9 dB. Theoretical modeling of multiple quantum well amplifiers was done using appropriate rate equations and a heuristic model of the carrier density dependent gain. The model gave a qualitative agreement with the experimental results. In addition, the model allowed exploration of a wider design space for the amplifiers. The model predicted that internal electrical-to-optical conversion efficiencies in excess of 50 percent should be achievable with careful system design. The model predicted that no global optimum design exists, but gain, efficiency, and optical confinement (coupling efficiency) can be mutually adjusted to meet a specific system requirement. A three quantum well, low optical confinement amplifier was fabricated using molecular beam epitaxial growth. Coherent beam combining of two high power amplifiers injected from a common master oscillator was also examined. Coherent beam combining with an efficiency of 93 percent resulted in a single beam having diffraction-limited characteristics. This beam combining efficiency is a world record result for such a system. Interferometric observations of the output of the amplifier indicated that spatial mode matching was a significant factor in the less than perfect beam combining. Finally, the system issues of arrays of amplifiers in a coherent beam combining system were investigated. Based upon experimentally observed parameters coherent beam combining could result in a megawatt-scale coherent beam with a 10 percent electrical-to-optical conversion efficiency

Synthesis and Reactions of Halogenated Polyethers and Polysulfides

Polyepichlorohydrin (PECH) is well known as a reactive elastomer. Displacement at the carbon-chlorine bond of PECH has been accomplished with a wide variety of nucleophilic reagents, for the purposes of polymer modification, grafting and cross1inking. On the other hand, the PECH structure is hardly optimal from the point of view of its reactivity as a substrate for nucleophilic substitution: chloride is modest in its leaving group ability, and the β-branch point (i.e. the chain backbone) would be expected to depress reaction rates by a factor of 10 or so

Cardiovascular disease in systemic sclerosis - an emerging association?

Microvascular disease is a prominent feature of systemic sclerosis (SSc) and leads to Raynaud's phenomenon, pulmonary arterial hypertension, and scleroderma renal crisis. The presence of macrovascular disease is less well established, and, in particular, it is not known whether the prevalence of coronary heart disease in SSc is increased. Furthermore, in terms of cardiac involvement in SSc, there remains conjecture about the relative contributions of atherosclerotic macrovascular disease and myocardial microvascular disease. In this review, we summarize the literature describing cardiovascular disease in SSc, discuss the pathophysiological mechanisms common to SSc and atherosclerosis, and review the surrogate markers of cardiovascular disease which have been examined in SSc. Proposed mediators of the vasculopathy of SSc which have also been implicated in atherosclerosis include endothelial dysfunction, a reduced number of circulating endothelial progenitor cells, and an increased number of microparticles. Excess cardiovascular risk in SSc is suggested by increased arterial stiffness and carotid intima thickening and reduced flow-mediated dilatation. Cohort studies of adequate size are required to resolve whether this translates into an increased incidence of cardiovascular events in patients with SSc

Phosphodiesterase-5 inhibitors in management of pulmonary hypertension: safety, tolerability, and efficacy

Pulmonary arterial hypertension (PAH) is a progressive disease that causes severe disability and has no cure. Over the past 20 years, a variety of treatment options have evolved for the management of PAH. With an expanded therapeutic armamentarium come more complex decisions regarding treatment options. Agent selection depends upon several factors including efficacy, side effect profile, and cost, as well as convenience of administration. We have undertaken a review of phosphodiesterase-5 (PDE-5) inhibitors in PAH with a focus on efficacy and safety. A literature search was conducted using the Medline and Cochrane Central Register of Controlled Trials databases (1966–February 2010) for relevant randomized clinical studies. Overall, 10 studies met our inclusion criteria. Sildenafil was the most commonly studied agent, followed by tadalafil and vardenafil. Most trials found that the PDE-5 inhibitors significantly improved exercise capacity and lowered pulmonary pressures. However, there were conflicting results regarding these agents’ impact on improving cardiac function and functional class. Overall, these medications were effective and well tolerated with a relatively benign side effect profile. The PDE-5 inhibitors are an important option in treating PAH. While most of the published clinical data involved sildenafil, the other PDE-5 inhibitors show promise as well. Further studies are needed to determine the optimal doses of this therapeutic drug class, as well as its effects as adjunctive therapy with other agents in PAH

Anisotropy of Solar Wind Turbulence between Ion and Electron Scales

The anisotropy of turbulence in the fast solar wind, between the ion and electron gyroscales, is directly observed using a multispacecraft analysis technique. Second order structure functions are calculated at different angles to the local magnetic field, for magnetic fluctuations both perpendicular and parallel to the mean field. In both components, the structure function value at large angles to the field S_perp is greater than at small angles S_par: in the perpendicular component S_perp/S_par = 5 +- 1 and in the parallel component S_perp/S_par > 3, implying spatially anisotropic fluctuations, k_perp > k_par. The spectral index of the perpendicular component is -2.6 at large angles and -3 at small angles, in broad agreement with critically balanced whistler and kinetic Alfven wave predictions. For the parallel component, however, it is shallower than -1.9, which is considerably less steep than predicted for a kinetic Alfven wave cascade.Comment: 4 pages, 4 figures, replaced to match published versio

Heavy-Quark Diffusion, Flow and Recombination at RHIC

We discuss recent developments in assessing heavy-quark interaction in the Quark-Gluon Plasma (QGP). While induced gluon radiation is expected to be the main energy-loss mechanism for fast-moving quarks, we focus on elastic scattering which prevails toward lower energies, evaluating both perturbative (gluon-exchange) and nonperturbative (resonance formation) interactions in the QGP. The latter are treated within an effective model for D- and B-meson resonances above T_c as motivated by current QCD lattice calculations. Pertinent diffusion and drag constants, following from a Fokker-Planck equation, are implemented into an expanding fireball model for Au-Au collisions at RHIC using relativistic Langevin simulations. Heavy quarks are hadronized in a combined fragmentation and coalescence framework, and resulting electron-decay spectra are compared to recent RHIC data. A reasonable description of both nuclear suppression factors and elliptic flow up to momenta of ~5 GeV supports the notion of a strongly interacting QGP created at RHIC. Consequences and further tests of the proposed resonance interactions are discussed.Comment: 8 pages, 14 figures, contribution to the proceedings for the "International Conference on Strangeness in Quark Matter 2006