Project Andvari: A Digital Portal to the Visual World of Early Medieval Northern Europe

Project Andvari is designed to provide integrated access to dispersed collections of northern European art and artifacts of the early medieval period (4th-12th centuries). Our goal is to create a digital portal offering aggregated search options and enhanced metadata. Funding is requested to convene an international workshop for humanities scholars, museum professionals, and technology experts to refine the conceptual design of the proposed research tool and identify its technological requirements in preparation for a pilot project. Ultimately, Project Andvari will facilitate interdisciplinary research in art, archaeology, history, and literary and religious studies of the northern periphery of medieval Europe. It will allow users to study visual culture across media and beyond traditional geographical and disciplinary boundaries. Its innovative application of search methods will promote analyses of relationships of artifacts and cultures, and help us discover the hitherto unnoticed

Ubic: Bridging the gap between digital cryptography and the physical world

Advances in computing technology increasingly blur the boundary between the digital domain and the physical world. Although the research community has developed a large number of cryptographic primitives and has demonstrated their usability in all-digital communication, many of them have not yet made their way into the real world due to usability aspects. We aim to make another step towards a tighter integration of digital cryptography into real world interactions. We describe Ubic, a framework that allows users to bridge the gap between digital cryptography and the physical world. Ubic relies on head-mounted displays, like Google Glass, resource-friendly computer vision techniques as well as mathematically sound cryptographic primitives to provide users with better security and privacy guarantees. The framework covers key cryptographic primitives, such as secure identification, document verification using a novel secure physical document format, as well as content hiding. To make a contribution of practical value, we focused on making Ubic as simple, easily deployable, and user friendly as possible.Comment: In ESORICS 2014, volume 8712 of Lecture Notes in Computer Science, pp. 56-75, Wroclaw, Poland, September 7-11, 2014. Springer, Berlin, German

Nanotailoring Stereolithography Resins for Unique Applications using Carbon Nanotubes

Nanostructured materials and exploiting their properties in stereolithography (SL) may open new markets for unique rapidly manufactured functional devices. Controlled amounts of multiwalled carbon nanotubes (MWCNTs) were successfully dispersed in SL epoxy-based resins and complex three-dimensional (3D) parts were successfully fabricated by means of a multi-material SL setup. The effect of the nanosized filler was evaluated using mechanical testing. Small dispersions of MWCNTs resulted in significant effects on the physical properties of the polymerized resin. A MWCNT concentration of .05 wt% (w/v) in DSM Somos® WaterShed™ 11120 resin increased the ultimate tensile stress and fracture stress an average of 17% and 37%, respectively. Electron microscopy was used to examine the morphology of the nanocomposite and results showed affinity between the MWCNTs and SL resin and identified buckled nanotubes that illustrated strong interfacial bonding. These improved physical properties may provide opportunities for using nanocomposite SL resins in end-use applications. Varying types and concentrations of nanomaterials can be used to tailor existing SL resins for particular applications.Mechanical Engineerin

Using fourth generation management in evaluating and improving the procurement process at the State Treasurer's Office

This paper deals with the procurement process at the State Treasurer's Office

Teaching Music Theory in High School Music classes: A Comparative Study of Current Practices in High Schools of the State of Washington

It was the purpose of this study to investigate the current educational practices in providing for the teaching of music theory in the high schools of the State of Washington

Repair of Oxidative DNA Damage and Cancer: Recent Progress in DNA Base Excision Repair

SIGNIFICANCE: Reactive oxygen species (ROS) are generated by exogenous and environmental genotoxins, but also arise from mitochondria as byproducts of respiration in the body. ROS generate DNA damage of which pathological consequence, including cancer is well established. Research efforts are intense to understand the mechanism of DNA base excision repair, the primary mechanism to protect cells from genotoxicity caused by ROS. RECENT ADVANCES: In addition to the notion that oxidative DNA damage causes transformation of cells, recent studies have revealed how the mitochondrial deficiencies and ROS generation alter cell growth during the cancer transformation. CRITICAL ISSUES: The emphasis of this review is to highlight the importance of the cellular response to oxidative DNA damage during carcinogenesis. Oxidative DNA damage, including 7,8-dihydro-8-oxoguanine, play an important role during the cellular transformation. It is also becoming apparent that the unusual activity and subcellular distribution of apurinic/apyrimidinic endonuclease 1, an essential DNA repair factor/redox sensor, affect cancer malignancy by increasing cellular resistance to oxidative stress and by positively influencing cell proliferation. FUTURE DIRECTIONS: Technological advancement in cancer cell biology and genetics has enabled us to monitor the detailed DNA repair activities in the microenvironment. Precise understanding of the intracellular activities of DNA repair proteins for oxidative DNA damage should provide help in understanding how mitochondria, ROS, DNA damage, and repair influence cancer transformation

Topical anti-inflammatory activity of Polygonum cuspidatum extract in the TPA model of mouse ear inflammation

<p>Abstract</p> <p>Background</p> <p>This study tested the ability of a characterized extract of <it>Polygonum cuspidatum </it>(PCE) to inhibit mouse ear inflammation in response to topical application of 12-<it>O-</it>tetradecanoylphorbol-13-acetate (TPA).</p> <p>Methods</p> <p>A 50% (wt:vol) ethanolic solution of commercial 200:1 PCE was applied to both ears of female Swiss mice (n = 8) at 0.075, 0.15, 0.3, 1.25 and 2.5 mg/ear 30 min after TPA administration (2 μg/ear). For comparison, 3 other groups were treated with TPA and either 1) the vehicle (50% ethanol) alone, 2) indomethacin (0.5 mg/ear), or 3) <it>trans</it>-resveratrol (0.62 mg/ear). Ear thickness was measured before TPA and at 4 and 24 h post-TPA administration to assess ear edema. Ear punch biopsies were collected at 24 h and weighed as a second index of edema. Myeloperoxidase activity was measured in each ear punch biopsy to assess neutrophil infiltration.</p> <p>Results</p> <p>PCE treatment at all doses significantly reduced ear edema compared to the TPA control. The PCE response was dose-dependent and 2.5 mg PCE significantly inhibited all markers of inflammation to a greater extent than indomethacin (0.5 mg). MPO activity was inhibited at PCE doses ≥ 1.25 mg/ear. <it>Trans-</it>resveratrol inhibited inflammation at comparable doses.</p> <p>Conclusion</p> <p>PCE inhibits development of edema and neutrophil infiltration in the TPA-treated mouse ear model of topical inflammation.</p

BITC Sensitizes Pancreatic Adenocarcinomas to TRAIL-Induced Apoptosis

Pancreatic adenocarcinoma is an aggressive cancer with a greater than 95% mortality rate and short survival after diagnosis. Chemotherapeutic resistance hinders successful treatment. This resistance is often associated with mutations in codon 12 of the K-Ras gene (K-Ras 12), which is present in over 90% of all pancreatic adenocarcinomas. Codon 12 mutations maintain Ras in a constitutively active state leading to continuous cellular proliferation. Our study determined if TRAIL resistance in pancreatic adenocarcinomas with K-Ras 12 mutations could be overcome by first sensitizing the cells with Benzyl isothiocyanate (BITC). BITC is a component of cruciferous vegetables and a cell cycle inhibitor. BxPC3, MiaPaCa2 and Panc-1 human pancreatic adenocarcinoma cell lines were examined for TRAIL resistance. Our studies show BITC induced TRAIL sensitization by dual activation of both the extrinsic and intrinsic apoptotic pathways

Early Cenozoic Fluvial Deposits of the Renova Formation in SW Montana: Links to Southern Nevada and Utah?

Examination of the early Cenozoic fluvial deposits of the Renova Formation provides support for the hypothesis that a southern branch of the pre-ice age Bell River of Canada, a river thought to have been the size of the Amazon, may have originated in the southern Colorado Plateau and flowed northward through Nevada, Utah, Idaho, and Montana. The Renova Formation mostly comprises fluvially-reworked and degraded volcanic ash. Radiometric ages of zircon grains from the Renova Formation, reported in the literature, correlate with the ages of zircons from ash-flow tuffs that erupted from mega-calderas in southern Nevada and Utah. There are also older zircons present in the Renova deposits which indicate recycling of zircon grains from Precambrian and Cambrian quartzites of Utah. These results provide evidence of river transport of ash and sand from Nevada and Utah into Montana. Previous research has been reviewed and assessed in the context of the Bell River hypothesis. A field trip was taken to physically observe the composition and depositional features of the Renova. Histograms generated by mass spectroscopy of Renova Formation zircon have been re-analyzed in light of the mega-caldera origin hypothesis. This new model suggests that a major, north-flowing Cenozoic drainage system was present in the western interior of North America before being segmented and destroyed by faulting and volcanism

Self-reported adverse reactions in 4337 healthcare workers immunizations against novel H1N1 influenza

Purpose: The use of the 2009 H1N1 vaccine has generated much debate concerning safety issues among the general population and physicians. Therefore, we investigated the safety of an inactivated monovalent H1N1 pandemic influenza vaccine Methods: We focused on the H1N1 pandemic influenza vaccine Pandemrix(R) and applied a self reporting questionnaire in a population of healthcare workers (HCWs) and medical students at a major university hospital. Results: In total, 4337 individuals were vaccinated, consisting of 3808 HCWs and 529 medical students. The vaccination rate of the employees was higher than 40%.The majority of individuals were vaccinated in November 2009. In total, 291 of the 4337 vaccinations were reported to lead to one or more adverse reactions (6.7%). Local reactions were reported in 3.8%, myalgia and arthralgia in 3.7%, fatigue in 3.7%, headache in 3.1%. Conclusions: Our data together with available data from several national and international institutions points to a safe pandemic influenza vaccine