Going to BAT: Assessing Disgust Sensitivity and Related Factors in Behavioral Avoidance

The present study used archival data (N = 194) consisting of responses from a battery of questionnaires and data from eight behavioral avoidance tasks (BATs). Correlational analyses demonstrated that disgust sensitivity, anxiety sensitivity, state disgust and anxiety ratings during BATs, and behavioral avoidance on BATs were significantly correlated. Higher disgust sensitivity and behavioral avoidance was also associated with being female. Unexpectedly, emotion dysregulation was not correlated with disgust sensitivity or behavioral avoidance. Next, a series of hierarchical multiple linear regressions indicated that the contamination disgust domain appeared to be the strongest predictor of behavioral avoidance on core- and contamination-related BATs, while animal reminder disgust appeared to be the strongest on animal reminder-related BATs. Surprisingly, core disgust did not individually predict avoidance on any associated BATs. A subsequent hierarchical multiple linear regression demonstrated that disgust sensitivity (Step 4) uniquely predicted steps refused on the BATs while controlling for gender (Step 1), state disgust and anxiety ratings (Step 2), and anxiety sensitivity and emotion dysregulation (Step 3). Interestingly, this model was not significant when examining distance approached on the BATs, and neither anxiety sensitivity nor emotion dysregulation significantly contributed to either models. Lastly, moderation analyses revealed that emotion dysregulation and anxiety sensitivity did not moderate the relationship between disgust sensitivity and behavioral avoidance. Overall, findings from the present study highlight that sensitivity towards the emotion of disgust is particularly important to increased behavioral avoidance in this context

IR-Singularities in Noncommutative Perturbative Dynamics?

We analyse the IR-singularities that appear in a noncommutative scalar quantum field theory on $\mathcal{E}_4$. We demonstrate with the help of the quadratic one-loop effective action and an appropriate field redefinition that no IR-singularities exist. No new degrees of freedom are needed to describe the UV/IR-mixing.Comment: 6 pages, amsLaTe

Postoperative Pyoderma Gangrenosum in Association with Renal Cell Carcinoma and Chronic Lymphocytic Leukemia

INTRODUCTION: Pyoderma gangrenosum (PG) is a rare sterile neutrophilic dermatosis characterized by painful recurrent ulcerations. It is frequently associated with inflammatory bowel disease, rheumatoid arthritis, or malignancies. PG is a diagnosis of exclusion, and it is based on clinical presentation, histology, history of an underlying disease, and exclusion of other causes of ulceration. CASE REPORT: The authors report a 62-year-old male who developed a nonhealing ulcer at the site of incision following nephrectomy for renal cell carcinoma. Past medical history included chronic lymphocytic leukemia treated with rituximab. Histology of the skin lesion showed a phlegmonous nonspecific inflammation without being able to differentiate between a necrotizing wound infection and PG. The patient’s condition was initially diagnosed as an infectious process and treated accordingly. After unsuccessful results with systemic antibiotics, high-dose corticosteroids induced prompt healing of the wound. On these bases, the diagnosis of postoperative PG within chronic lymphocytic leukemia and renal cell carcinoma was made. CONCLUSION: Faced with postoperative necrotizing ulceration resistant to correctly administered antibiotics, PG must be considered. In such condition, the diagnosis must not be guided primarily by histology and early advice of a dermatologist is recommended

In vitro models as tools for screening treatment options of head and neck cancer

Various in vitro models using primary and established 2- and 3-dimensional cultures, multicellular tumor spheroids, standardized tumor slice cultures, tumor organoids, and microfluidic systems obtained from tumor lesions/biopsies of head and neck cancer (HNC) have been employed for exploring and monitoring treatment options. All of these in vitro models are to a different degree able to capture the diversity of tumors, recapitulate the disease genetically, histologically, and functionally and retain their tumorigenic potential upon xenotransplantation. The models were used for the characterization of the malignant features of the tumors and for in vitro screens of drugs approved for the treatment of HNC, including chemotherapy and radiotherapy as well as recently developed targeted therapies and immunotherapies, or for novel treatments not yet licensed for these tumor entities. The implementation of the best suitable model will enlarge our knowledge of the oncogenic properties of HNC, expand the drug repertoire and help to develop individually tailored treatment strategies resulting in the translation of these findings into the clinic. This review summarizes the different approaches using preclinical in vitro systems with their advantages and disadvantages and their implementation as preclinical platforms to predict disease course, evaluate biomarkers and test therapy efficacy.Peer reviewe

Analysis of Two-Dimensional Photoelectron Momentum Spectra and the Effect of the Long-Range Coulomb Potential in Single Ionization of Atoms by Intense Lasers

Two-dimensional (2D) electron momentum distributions and energy spectra for multiphoton ionization of atoms by intense laser pulses, calculated by solving the time-dependent Schrödinger equation (TDSE) for different wavelengths and intensities, are compared to those predicted by the strong-field approximation (SFA). It is shown that the momentum spectra at low energies between the TDSE and SFA are quite different and the differences arise largely from the absence of a long-range Coulomb interaction in the SFA. We further found that the low-energy 2D momentum spectra from the TDSE exhibit ubiquitous fanlike features where the number of stripes is due to a single dominant angular momentum of the low-energy electron. The specific dominant angular momentum in turn has been found to be decided by the minimum number of photons needed to ionize the atom only. The electron momentum spectra predicted by models modified from the SFA are also examined and found to lack the fanlike features as in the SFA

Signatures of tunneling and multiphoton ionization in the electron-momentum distributions of atoms by intense few-cycle laser pulses

Electron-momentum distributions for above-threshold ionization of argon in a few-cycle, linearly polarized laser pulse are investigated. Spectral features characteristic of multiphoton as well as tunneling ionization coexist over a range of the Keldysh parameter gamma in the transition regime gamma~1. Surprisingly, the simple strong-field approximation (SFA) is capable of reproducing the key features of the two-dimensional momentum distributions found in the full solution of the time-dependent Schrödinger equation, despite the fact that SFA is known to severely underestimate the total ionization probability

The Energy-Momentum Tensor in Noncommutative Gauge Field Models

We discuss the different possibilities of constructing the various energy-momentum tensors for noncommutative gauge field models. We use Jackiw's method in order to get symmetric and gauge invariant stress tensors--at least for commutative gauge field theories. The noncommutative counterparts are analyzed with the same methods. The issues for the noncommutative cases are worked out.Comment: 11 pages, completed reference