Emergence and rapid global dissemination of CTX-M-15-associated Klebsiella pneumoniae strain ST307

Abstract Recent reports indicate the emergence of a new carbapenemase producing Klebsiella pneumoniae clone, ST307. Here we show that ST307 emerged in the mid-1990s (nearly 20 years prior to its first report), is already globally distributed and is intimately associated with a conserved plasmid harbouring the bla CTX-M-15 extended-spectrum beta-lactamase (ESBL) gene plus other antimicrobial resistance determinants. Our findings support the need for enhanced surveillance of this widespread ESBL clone in which carbapenem resistance is now emerging

Solitosynthesis of Q-balls

We study the formation of Q-balls in the early universe, concentrating on potentials with a cubic or quartic attractive interaction. Large Q-balls can form via solitosynthesis, a process of gradual charge accretion, provided some primordial charge assymetry and initial ``seed'' Q-balls exist. We find that such seeds are possible in theories in which the attractive interaction is of the form $A H \psi^* \psi$, with a light ``Higgs'' mass. Condensate formation and fragmentation is only possible for masses $m_\psi$ in the sub-eV range; these Q-balls may survive untill present.Comment: 9 pages, 1 figur

Reactivity of Gold Hydrides: O2 Insertion into the Au–H Bond

Dioxygen reacts with the gold(I) hydride (IPr)AuH under insertion to give the hydroperoxide, (IPr)AuOOH, a long-postulated reaction in gold catalysis and the first demonstration of O2 activation by Au-H in a well-defined system. Subsequent condensation gave the peroxide (IPr)Au-OO-Au(IPr) (IPr = 1,3-bis(2,6-diisopropylphenyl)imidazole-2-ylidene). The reaction kinetics are reported, as well as the reactivity of Au(I) hydrides with radical scavengers