Modeling Temporal Pattern and Event Detection using Hidden Markov Model with Application to a Sludge Bulking Data

This paper discusses a method of modeling temporal pattern and event detection based on Hidden Markov Model (HMM) for a continuous time series data. We also provide methods for checking model adequacy and predicting future events. These methods are applied to a real example of sludge bulking data for detecting sludge bulking for a water plant in Chicago

A novel mechanism for binding of galactose-terminated glycans by the C-type carbohydrate recognition domain in blood dendritic cell antigen 2

Blood dendritic cell antigen 2 (BDCA-2; also designated CLEC4C or CD303) is uniquely expressed on plasmacytoid dendritic cells. Stimulation of BDCA-2 with antibodies leads to an anti-inflammatory response in these cells, but the natural ligands for the receptor are not known. The C-type carbohydrate recognition domain in the extracellular portion of BDCA-2 contains a signature motif typical of C-type animal lectins that bind mannose, glucose, or GlcNAc, yet it has been reported that BDCA-2 binds selectively to galactose-terminated, biantennary N-linked glycans. A combination of glycan array analysis and binding competition studies with monosaccharides and natural and synthetic oligosaccharides have been used to define the binding epitope for BDCA-2 as the trisaccharide Galβ1–3/4GlcNAcβ1–2Man. X-ray crystallography and mutagenesis studies show that mannose is ligated to the conserved Ca2+ in the primary binding site that is characteristic of C-type carbohydrate recognition domains, and the GlcNAc and galactose residues make additional interactions in a wide, shallow groove adjacent to the primary binding site. As predicted from these studies, BDCA-2 binds to IgG, which bears galactose-terminated glycans that are not commonly found attached to other serum glycoproteins. Thus, BDCA-2 has the potential to serve as a previously unrecognized immunoglobulin Fc receptor

Generalised Wick Transform in Dimensionally Reduced Gravity

In the context of canonical quantum gravity, we study an alternative real quantisation scheme, which is arising by relating simpler Riemannian quantum theory to the more complicated physical Lorentzian theory - the generalised Wick transform. On the symmetry reduced models, homogenous Bianchi cosmology and 2+1 gravity, we investigate its generalised construction principle, demonstrate that the emerging quantum theory is equivalent to the one obtained from standard quantisation and how to obtain physical states in Lorentzian gravity from Wick transforming solutions of Riemannian quantum theory.Comment: 25 pages, 3 figures, revtex4; v.2: referencing improve

Average-Case Optimal Approximate Circular String Matching

Approximate string matching is the problem of finding all factors of a text t of length n that are at a distance at most k from a pattern x of length m. Approximate circular string matching is the problem of finding all factors of t that are at a distance at most k from x or from any of its rotations. In this article, we present a new algorithm for approximate circular string matching under the edit distance model with optimal average-case search time O(n(k + log m)/m). Optimal average-case search time can also be achieved by the algorithms for multiple approximate string matching (Fredriksson and Navarro, 2004) using x and its rotations as the set of multiple patterns. Here we reduce the preprocessing time and space requirements compared to that approach

Intracranial hypotension secondary to spinal arachnoid cyst rupture presenting with acute severe headache: a case report

<p>Abstract</p> <p>Introduction</p> <p>Headache is a common presenting complaint and has a wide differential diagnosis. Clinicians need to be alert to clues that may suggest an underlying secondary aetiology. We describe a novel case of headache secondary to intracranial hypotension which was precipitated by the rupture of a spinal arachnoid cyst.</p> <p>Case report</p> <p>A 51-year-old Indian female presented with sudden onset severe headache suggestive of a subarachnoid haemorrage. Investigations including a computed tomography brain scan, cerebrospinal fluid examination and a magnetic resonance angiogram were normal. The headache persisted and magnetic resonance imaging revealed bilateral thin subdural collections, a spinal subarachnoid cyst and a right-sided pleural effusion. This was consistent with a diagnosis of headache secondary to intracranial hypotension resulting from spinal arachnoid cyst rupture.</p> <p>Conclusions</p> <p>Spinal arachnoid cyst rupture is a rare cause of spontaneous intracranial hypotension. Spontaneous intracranial hypotension is a common yet under-diagnosed heterogeneous condition. It should feature significantly in the differential diagnosis of patients with new-onset daily persistent headache.</p

Effect of using micropalm oil fuel ash as partial replacement of cement on the properties of cement mortar

This study investigates the effects of micropalm oil fuel ash (mPOFA) on compressive strength and pore structure of cement mortar. Various experimental techniques, such as compression test, isothermal calorimetry, mercury intrusion porosimetry, and X-ray diffraction, are performed to figure out the effect of using mPOFA as partial replacement of cement on the hydration of cement and determine its optimal replacement level to increase mechanical property of the mortar specimens. 10 wt.% of cement replacement with mPOFA is found to give the highest level of compressive strength, achieving a 23% increase over the control specimens after 3 days of curing. High K2O contents in mPOFA stimulate C3S in cement to form C-S-H at early ages, and high surface area of mPOFA acts as a nucleus to develop C-S-H. Also, small mPOFA particles and C-S-H formed by pozzolanic reaction fill the pores and lead to reduction in large capillary pores. In XRD analysis, a decrease in Ca(OH)2 and SiO2 contents with age confirmed a high pozzolanic reactivity of mPOFA

Common Polymorphisms in Human Langerin Change Specificity for Glycan Ligands

Langerin, a C-type lectin on Langerhans cells, mediates carbohydrate-dependent uptake of pathogens in the first step of antigen presentation to the adaptive immune system. Langerin binds a diverse range of carbohydrates including high mannose structures, fucosylated blood group antigens, and glycans with terminal 6-sulfated galactose. Mutagenesis and quantitative binding assays indicate that salt bridges between the sulfate group and two lysine residues compensate for the nonoptimal binding of galactose at the primary Ca(2+) site. A commonly occurring single nucleotide polymorphism (SNP) in human langerin results in change of one of these lysine residues, Lys-313, to isoleucine. Glycan array screening reveals that this amino acid change abolishes binding to oligosaccharides with terminal 6SO(4)-Gal and enhances binding to oligosaccharides with terminal GlcNAc residues. Structural analysis shows that enhanced binding to GlcNAc may result from Ile-313 packing against the N-acetyl group. The K313I polymorphism is tightly linked to another SNP that results in the change N288D, which reduces affinity for glycan ligands by destabilizing the Ca(2+)-binding site. Langerin with Asp-288 and Ile-313 shows no binding to 6SO(4)-Gal-terminated glycans and increased binding to GlcNAc-terminated structures, but overall decreased binding to glycans. Altered langerin function in individuals with the linked N288D and K313I polymorphisms may affect susceptibility to infection by microorganisms

The Effects of Climate Change on Seasonal Snowpack and the Hydrology of the Northeastern and Upper Midwest United States

Permission to use figures, tables, and brief excerpts from this work in scientific and educational works is hereby granted provided that the source is acknowledged. Any use of material in this work that is determined to be “fair use” under Section 107 of the U.S. Copyright Act or that satisfies the conditions specified in Section 108 of the U.S. Copyright Act (17 USC §108) does not require the AMS’s permission. Republication, systematic reproduction, posting in electronic form, such as on a website or in a searchable database, or other uses of this material, except as exempted by the above statement, requires written permission or a license from the AMS. All AMS journals and monograph publications are registered with the Copyright Clearance Center (http://www.copyright.com). Questions about permission to use materials for which AMS holds the copyright can also be directed to the AMS Permissions Officer at [email protected]. Additional details are provided in the AMS Copyright Policy statement, available on the AMS website (http://www.ametsoc.org/CopyrightInformation).The potential effects of climate change on the snowpack of the northeastern and upper Midwest United States are assessed using statistically downscaled climate projections from an ensemble of 10 climate models and a macroscale hydrological model. Climate simulations for the region indicate warmer-than-normal temperatures and wetter conditions for the snow season (November–April) during the twenty-first century. However, despite projected increases in seasonal precipitation, statistically significant negative trends in snow water equivalent (SWE) are found for the region. Snow cover is likely to migrate northward in the future as a result of warmer-than-present air temperatures, with higher loss rates in northern latitudes and at high elevation. Decreases in future (2041–95) snow cover in early spring will likely affect the timing of maximum spring peak streamflow, with earlier peaks predicted in more than 80% of the 124 basins studied

Electronic structures of Zn1−x_{1-x}Cox_xO using photoemission and x-ray absorption spectroscopy

Electronic structures of Zn$_{1-x}$Co$_x$O have been investigated using photoemission spectroscopy (PES) and x-ray absorption spectroscopy (XAS). The Co 3d states are found to lie near the top of the O $2p$ valence band, with a peak around $\sim 3$ eV binding energy. The Co $2p$ XAS spectrum provides evidence that the Co ions in Zn$_{1-x}$Co$_{x}$O are in the divalent Co$^{2+}$ ($d^7$) states under the tetrahedral symmetry. Our finding indicates that the properly substituted Co ions for Zn sites will not produce the diluted ferromagnetic semiconductor property.Comment: 3 pages, 2 figure