317 research outputs found

    Language Management in a Multinational Workforce: The Knowledge Worker Perspective

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    Organisations recruiting knowledge workers worldwide face a considerable challenge with regard to the choice of corporate language. The use of English as a lingua franca is often perceived as the most obvious option. However, there may be good arguments for using the host country language even in cases where the language in question is relatively small and the English skills of the local population are high. Our paper reports on the results of a study of a Nordic organisation that has chosen the local language as its corporate language. We investigate the implications for the employees’ professional and social identity and also discuss the language ideology underlying this choice. The study is based on both interviews and a survey conducted among both local and international members of the organization

    Problematisation and regulation: bodies, risk, and recovery within the context of Neonatal Abstinence Syndrome

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    Background Neonatal Abstinence Syndrome (NAS) is an anticipated effect of maternal drug use during pregnancy. Yet it remains a contested area of policy and practice. In this paper, we contribute to ongoing debates about the way NAS is understood and responded to, through different treatment regimes, or logics of care. Our analysis examines the role of risk and recovery discourses, and the way in which the bodies of women and babies are conceptualised within these. Methods Qualitative interviews with 16 parents (9 mothers, 7 fathers) and four focus groups with 27 health and social care professionals based in Scotland. All the mothers were prescribed opioid replacement therapy and parents were interviewed after their baby was born. Data collection explored understandings about the causes and consequences of NAS and experiences of preparing for, and caring for, a baby with NAS. Data were analysed using a narrative and discursive approach. Results Parent and professional accounts simultaneously upheld and subverted logics of care which govern maternal drug use and the assessment and care of mother and baby. Despite acknowledging the unpredictability of NAS symptoms and the inability of the women who are opioid-dependent to prevent NAS, logics of care centred on ‘proving’ risk and recovery. Strategies appealed to the need for caution, intervening and control, and obscured alternative logics of care that focus on improving support for mother-infant dyads and the family as a whole. Conclusion Differing notions of risk and recovery that govern maternal drug use, child welfare and family life both compel and trouble all logics of care. The contentious nature of NAS reflects wider socio-political and moral agendas that ultimately have little to do with meeting the needs of mothers and babies. Fundamental changes in the principles, quality and delivery of care could improve outcomes for families affected by NAS

    Substance use in pregnancy. A resource pack for professionals in Lothian.

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    Contents: Introduction - page 7 Key points - page 11 Setting the scene - page 15 • The extent of the problem • The nature of the problem Framework for care - page 21 • Philosophy of approach Women and family centred approach - page 21 Guidelines on good practice- page.25 • The care process Information and guidelines on drug use - page 31 Drugs and their effects on the developing baby - page 35 • Evidence base Neonatal Abstinence Syndrome (NAS) - page 43 Management of substance use in pregnancy - page 51 • Smoking cessation • Advice on alcohol consumption • Assessing drug related problems • Management of problem drug use • Maternity care - page.65 • Pre-conceptual care • Antenatal care • Risk assessment during pregnancy • Intrapartum care (labour and childbirth) • Infant feeding • Postnatal care Assessing and managing child care risk during pregnancy - page 95 Appendices - page 127 1. Blood Borne Viruses 2. Link Midwives (Substance Misuse) 3. Link Health Visitors (Substance Misuse) 4. Model Care Pathway 5. Consent form for multi-disciplinary working 6. GP allocation proforma letter 7. T-ACE alcohol screening questionnaire 8. Drug & Alcohol Diary 9. Midwifery Liaison Forms (Substance Misuse) 10. NAS assessment score chart 11. Leaflet: Pregnant… and using alcohol and drugs? 12. Leaflet: Caring for a baby with drug withdrawal symptom

    Pyrophosphate dependent phosphofructokinsase (PFP) activity and other aspects of sucrose metabolism in sugarcane internodal tissues.

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    Thesis (Ph.D.)-University of Natal, Durban, 1997.The biochemical basis for the regulation of sucrose accumulation is not fully understood. The present study was thus aimed at investigating aspects of 'coarse' (enzyme activity) and 'fine' (metabolite) control of glycolytic enzyme activity in relation to carbon partitioning in the developing stalk (internodes 3 to 10), and between varieties with significant differences in sucrose content. Particular emphasis was placed on studying pyrophosphate: D-fructose-6-phosphate 1-phosphotransferase (PFP, EC 2.7.1.90), since this enzyme has been implicated in sucrose metabolism in other plant species. Within the developing stalk, internodal maturation was associated with a redirection carbon from the insoluble matter and total respiration (C02 production and biosynthesis) to sucrose storage. Between varieties, with significant variation in sucrose content, there was an inverse relationship between hexose monophosphate partitioning into respiration and sucrose. The reduction in carbon flux to respiration was not associated with a decline in the extractable specific activity of PK, PFK and PFP. There was also no alteration in the regulation of PK, PFK and FBPase by change in the mass action ratios. Hexose monophosphate concentration declined approximately two to three-fold from internodes 3 to 9 and Fru-6-P concentration was within the lower Km or 80.5 range (Fru-6-P) of PFP and PFK, respectively (as reported from the literature) . Within the developing stalk, substrate limitation might have contributed to the decline in carbon partitioning to respiration. In sugarcane, the levels of PFP activity were controlled in part by PFP protein expression. 8ugarcane PFP polypeptide(s) are resolved as a single protein with a molecular mass of approximately 72 kO. PFP catalysed a reaction close to equilibrium in all intemodes investigated, and the concentration of Fru-2,6-P2 was shown to be in excess of the requirement to stimulate PFP activity. Carbon flux from the triose-P to hexose monophosphate pool was apparent in sugarcane, suggesting that PFP activity was functional in vivo. The developmental profile of specific PFP activity was not positively correlated to the increasing rate of sucrose accumulation in the top ten internodes of the developing stalk. Between different sugarcane varieties, specific PFP activity was shown to be inversely correlated to sucrose content

    Parents and substance use. Editorial Essay, special themed collection

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    First paragraph: Parents who use substances are the focus of governmental concern and moral opprobrium internationally, and their children are specifically targeted for social services intervention. Policies that inform practice for parents who use substances are complex and contradictory. There is widespread concern regarding the impact of parental substance use on the welfare of children, but little scientific/clinical consensus regarding what aspects of substance use represent risk or harm to children. This is despite an increasing emphasis on evidence-based policy and practice. Similarly, there is wide variability in how far poverty, poor housing or domestic violence are understood to mediate in child welfare outcomes in families with multiple and complex needs.Output Type: Editoria

    Parenting support for mothers and fathers with a drug problem: issues and challenges for parents and healthcare professionals

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    This briefing was based on findings from a two year longitudinal qualitative study funded by the NHS Lothian Health Services Research Unit.The situation in Scotland - Addressing the needs of children and families affected by parental substance misuse (alcohol and drugs) is a priority for policy and practice (Scottish Government, 2013). The number of adults dependent on opiods and/or benzodiazephines has increased in recent years, and it is estimated that up to 60,000 children in Scotland are affected by a parent's drug use. Policy initiatives emphasise the importance of early intervention alongside evidence-based parenting interventions and recovery-orientated substance misuse treatment (ACDM, 2003; Scottish Government, 2008; Scottish Government, 2012)

    Treatment of post-traumatic stress disorder and substance use disorder in adults with a history of adverse childhood experiences: A systematic review of psychological interventions

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    Background Adverse childhood experiences (ACEs) have long-term effects on adult health, including unresolved trauma and substance use disorder (SUD). There are hypotheses of a mediating role of emotion regulation. This systematic literature review and narrative synthesis assessed the effectiveness of psychological interventions on emotion regulation, PTSD and SUD symptoms. Methods Searches were conducted using the Cochrane Handbook for Systematic Reviews methodology. Eligible studies were randomised controlled trials (RCTs) and quasi-experimental psychological interventions published between 2009 and 2019. Study characteristics, results and methodological quality were systematically analysed. Results Thirteen studies, including nine RCTs, were selected. Integrated SUD and PTSD treatments consisted of Seeking Safety, exposure-based treatment, Trauma Recovery and Empowerment Model, and integrated cognitive behavioural therapy. Two studies reported emotion regulation. Five studies found a small to medium positive effect size of psychological interventions on PTSD outcomes. Two studies had a small positive effect size on SUD outcomes and two a small negative effect size. Attrition was high across most studies. Characteristics likely to affect the applicability of the review were described. Conclusion The review found some evidence of a small inconsistent positive effect of psychological interventions on PTSD outcomes, and no evidence of effect on SUD outcomes. The range of theoretical models was narrow. Overall quality was low with high clinical heterogeneity and missing key information, particularly on emotion regulation, an important transdiagnostic feature. Further research is required to establish interventions that can treat these multiple conditions with a focus on effectiveness, acceptability, and implementation in real life clinical practice

    Sucrose phosphate synthase activity and the co-ordination of carbon partitioning during sucrose and amino acid accumulation in desiccation-tolerant leaf material of the C4 resurrection plant Sporobolus stapfianus during dehydration.

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    Both sucrose and amino acids accumulate in desiccation-tolerant leaf material of the C(4) resurrection plant, Sporobolus stapfianus Gandoger (Poaceae). The present investigation was aimed at examining sucrose phosphate synthase (SPS) activity and various metabolic checkpoints involved in the co-ordination of carbon partitioning between these competing pathways during dehydration. In the initial phase of dehydration, photosynthesis and starch content declined to immeasurable levels, whilst significant increases in hexose sugars, sucrose, and amino acids were associated with concomitant significant increases in SPS and pyruvate kinase (PK) activities, and maximal activity levels of phosphoenolpyruvate carboxylase (PEPCase), NADP-dependent isocitrate dehydrogenase (NADP-ICDH), and NADH-dependent glutamate synthase (NADH-GOGAT). The next phase of dehydration was characterized by changes in metabolism coinciding with net hexose sugar phosphorylation. This phase was characterized by a further significant increase in sucrose accumulation, with increased rates of net sucrose accumulation and maximum rates of SPS activity measured under both saturating and limiting (inhibitory) conditions. SPS protein was also increased. The stronger competitive edge of SPS for carbon entering glycolysis during hexose phosphorylation was also demonstrated by the further decrease in respiration and the simultaneous, significant decline in both PEPCase and PK activities. A decreased anabolic demand for 2-oxoglutarate (2OG), which remained constant, was shown by the co-ordinated decrease in GOGAT. It is proposed that the further increase in amino acids in this phase of dehydration may be in part attributable to the breakdown of insoluble proteins

    GGE Biplot Analysis to Explore the Adaption Potential of Italian Common Wheat Genotypes

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    Given the substantial variation in global wheat yield, insufficient research in cultivar selection for climate change, and the lack of suitable germplasm in sustainable agroecosystems, there is a requisite for soft wheat genotypes, with stable grain yield as well as quality parameters. The present study was aimed at genotype evaluation (GGE biplot for “mean performance versus stability”) not only for yield, but also for technological, phytosanitary and functional quality parameters of 24 Triticum aestivum L. genotypes (eight landraces, old and modern varieties, respectively) within a single organic farm location (Argelato, Emilia-Romagna, Italy) over three consecutive years. Overall, high yield stability was shown for the landraces and old varieties. In particular, the landraces Piave and Gamba di Ferro, as well as the old variety Verna, showed high stability with above-average means for numerous quality parameters of interest. Additionally, relative stability combined with above-average mean for quality parameters was also demonstrated for the high-yielding Gentil Bianco and Guà 113. Aside from Verna, these “unrecognized” resilient genotypes were also shown to meet the requisites for suitable germplasm in sustainable agroecosystems. Future potential utilization of these more stable landraces in addressing climate change would also ultimately facilitate the survival of valuable genetic resources
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