Latest Development of the Interstate Commerce Power

The litigation under the anti-lottery act of 1895, has for the first time raised the important constitutional question whether congress, under its general power to regulate interstate commerce, can select any particular article and exclude it from interstate commerce altogether-whether the power to regulate involves the power to prohibit. For nearly a century after the foundation of the government no attempt was made by congress to restrict interstate commerce by excluding any article therefrom. Quarantine legislation, however, opened the way, and the anti-lottery act sharply raised the question of power. Lottery tickets in the earliest days of the republic were the subjects of lawful and popular, and even pious traffic. They were among the most universal means of raising money. They built churches, schools and colleges. They were used by the United States government itself as a fiscal agency. Bold would have been the man who would dare predict what has, however, happened-that lottery tickets in a century would be regarded by the great majority of the people as an evil, and would be prohibited by the legislature of almost every state. Congress first excluded them from the mails, and this, after much litigation, was sustained under the general power to conduct the mails. Congress next, in 1895, took a more radical step and excluded them from interstate commerce altogether. This raised two interesting questions under the power to regulate commerce; first, whether a lottery ticket is an article of commerce at all; and second, whether the power to regulate commerce implies the power to prohibit it

Doctrine of Stare Decisis

I am requested to present a paper whose theme is suggested by the Present Problems of Private Law, as distinguished from law that has a constitutional or international aspect. I doubt whether there is any other section of the Congress whose themes are so difficult to select. We cover, indeed, those branches that mainly concern the ordinary, plain, steady-going, stay-at-home, law-abiding citizen,-that multitude of questions among which most legal practitioners everywhere are wearing out their lives; working every day and all day upon Present Problems of Private Law. Each of those problems interests the parties to the particular litigation or negotiation or dispute or difficulty which brings it up. Some interest even the lawyers to whom they are presented. Few interest anybody else; and even among these few but a small minority possess such worldwide interest that they are worthy of the consideration of a Congress representing all the civilized nations of the globe. Furthermore, this is not an International Congress of Lawyers. There is such a Congress; but it is a different one, and does not meet until next week. This is a Congress of Arts and Science; and of all the Present Problems of Private Law none is so difficult as to give to any portion of Private Law, as known at least to the American practitioner, the semblance either of a Science or of an Art

Absolute diffuse calibration of IRAC through mid-infrared and radio study of HII regions

We investigate the diffuse absolute calibration of the InfraRed Array Camera on the Spitzer Space Telescope at 8.0microns using a sample of 43 HII regions with a wide range of morphologies near GLON=312deg. For each region we carefully measure sky-subtracted,point-source- subtracted, areally-integrated IRAC 8.0-micron fluxes and compare these with Midcourse Space eXperiment (MSX) 8.3-micron images at two different spatial resolutions, and with radio continuum maps. We determine an accurate median ratio of IRAC 8.0-micron/MSX\8.3-micron fluxes, of 1.55+/-0.15. From robust spectral energy distributions of these regions we conclude that the present 8.0-micron diffuse calibration of the SST is 36% too high compared with the MSX validated calibration, perhaps due to scattered light inside the camera. This is an independent confirmation of the result derived for the diffuse calibration of IRAC by the Spitzer Science Center (SSC). From regression analyses we find that 843-MHz radio fluxes of HII regions and mid-infrared (MIR) fluxes are linearly related for MSX at 8.3-microns and Spitzer at 8.0 microns, confirming the earlier MSX result by Cohen & Green. The median ratio of MIR/843-MHz diffuse continuum fluxes is 600 times smaller in nonthermal than thermal regions, making it a sharp discriminant. The ratios are largely independent of morphology up to a size of ~24 arcsec. We provide homogeneous radio and MIR morphologies for all sources. MIR morphology is not uniquely related to radio structure. Compact regions may have MIR filaments and/or diffuse haloes, perhaps infrared counter- parts to weakly ionized radio haloes found around compact HII regions. We offer two IRAC colour-colour plots as quantitative diagnostics of diffuse HII regions.Comment: 29 pages, LaTeX (aastex), incl. 31 PostScript (ps,eps) figures and 5 tables. Accepted by MNRAS (main journal). Replaced an unused file and added this URL for people wishing to download a version with high-resolution images: http://www.astro.wisc.edu/sirtf/martin.hii.accepted.pd

Increased expression of programmed death ligand 1 (PD-L1) in human pituitary tumors

PURPOSE: Subsets of pituitary tumors exhibit an aggressive clinical courses and recur despite surgery, radiation, and chemotherapy. Because modulation of the immune response through inhibition of T-cell checkpoints has led to durable clinical responses in multiple malignancies, we explored whether pituitary adenomas express immune-related biomarkers that could suggest suitability for immunotherapy. Specifically, programmed death ligand 1 (PD-L1) has emerged as a potential biomarker whose expression may portend more favorable responses to immune checkpoint blockade therapies. We thus investigated the expression of PD-L1 in pituitary adenomas. METHODS: PD-L1 RNA and protein expression were evaluated in 48 pituitary tumors, including functioning and non-functioning adenomas as well as atypical and recurrent tumors. Tumor infiltrating lymphocyte populations were also assessed by immunohistochemistry. RESULTS: Pituitary tumors express variable levels of PD-L1 transcript and protein. PD-L1 RNA and protein expression were significantly increased in functioning (growth hormone and prolactin-expressing) pituitary adenomas compared to non-functioning (null cell and silent gonadotroph) adenomas. Moreover, primary pituitary adenomas harbored higher levels of PD-L1 mRNA compared to recurrent tumors. Tumor infiltrating lymphocytes were observed in all pituitary tumors and were positively correlated with increased PD-L1 expression, particularly in the functional subtypes. CONCLUSIONS: Human pituitary adenomas harbor PD-L1 across subtypes, with significantly higher expression in functioning adenomas compared to non-functioning adenomas. This expression is accompanied by the presence of tumor infiltrating lymphocytes. These findings suggest the existence of an immune response to pituitary tumors and raise the possibility of considering checkpoint blockade immunotherapy in cases refractory to conventional management

G313.3+00.3: A New Planetary Nebula discovered by the Australia Telescope Compact Array and the Spitzer Space Telescope

We present a new planetary nebula, first identified in images from the Australia Telescope Compact Array, although not recognized at that time. Recent observations with the Spitzer Space Telescope during the GLIMPSE Legacy program have rediscovered the object. The high-resolution radio and infrared images enable the identification of the central star or its wind, the recognition of the radio emission as thermal, and the probable presence of polycylic aromatic hydrocarbons in and around the source. These lead to the conclusion that G313.3+00.3 is a planetary nebula. This object is of particular interest because it was discovered solely through radio and mid-infrared imaging, without any optical (or near-infrared) confirmation, and acts as a proof of concept for the discovery of many more highly extinguished planetary nebulae. G313.3+00.3 is well-resolved by both the instruments with which it was identified, and suffers extreme reddening due to its location in the Scutum-Crux spiral arm.Comment: 18 pages, LaTeX (aastex), incl. 8 PostScript (eps) figures and 1 table. Accepted by ApJ (Part 1

Spitzer IRAC observations of newly-discovered planetary nebulae from the Macquarie-AAO-Strasbourg H-alpha Planetary Nebula Project

We compare H-alpha, radio continuum, and Spitzer Space Telescope (SST) images of 58 planetary nebulae (PNe) recently discovered by the Macquarie-AAO-Strasbo- urg H-alpha PN Project (MASH) of the SuperCOSMOS H-alpha Survey. Using InfraRed Array Camera (IRAC) data we define the IR colors of PNe and demonstrate good isolation between these colors and those of many other types of astronomical object. The only substantive contamination of PNe in the color-color plane we illustrate is due to YSOs. However, this ambiguity is readily resolved by the unique optical characteristics of PNe and their environs. We also examine the relationships between optical and MIR morphologies from 3.6 to 8.0um and explore the ratio of mid-infrared (MIR) to radio nebular fluxes, which is a valuable discriminant between thermal and nonthermal emission. MASH emphasizes late evolutionary stages of PNe compared with previous catalogs, enabling study of the changes in MIR and radio flux that attend the aging process. Spatially integrated MIR energy distributions were constructed for all MASH PNe observed by the GLIMPSE Legacy Project, using the H-alpha morphologies to establish the dimensions for the calculations of the Midcourse Space Experiment (MSX), IRAC, and radio continuum (from the Molonglo Observatory Synthesis Telescope and the Very Large Array) flux densities. The ratio of IRAC 8.0-um to MSX 8.3-um flux densities provides a measure of the absolute diffuse calibration of IRAC at 8.0 um. We independently confirm the aperture correction factor to be applied to IRAC at 8.0um to align it with the diffuse calibration of MSX. The result agrees with the recommendations of the Spitzer Science Center and with results from a parallel study of HII regions. These PNe probe the diffuse calibration of IRAC on a spatial scale of 9-77 arcsec.Comment: 48 pages, LaTeX (aastex), incl. 18 PostScript (eps) figures and 3 tables. Accepted by Astrophysical Journa

LOW-FREQUENCY OBSERVATIONS OF THE MOON WITH THE MURCHISON WIDEFIELD ARRAY

A new generation of low-frequency radio telescopes is seeking to observe the redshifted 21 cm signal from the epoch of reionization (EoR), requiring innovative methods of calibration and imaging to overcome the difficulties of wide-field low-frequency radio interferometry. Precise calibration will be required to separate the expected small EoR signal from the strong foreground emission at the frequencies of interest between 80 and 300 MHz. The Moon may be useful as a calibration source for detection of the EoR signature, as it should have a smooth and predictable thermal spectrum across the frequency band of interest. Initial observations of the Moon with the Murchison Widefield Array 32 tile prototype show that the Moon does exhibit a similar trend to that expected for a cool thermally emitting body in the observed frequency range, but that the spectrum is corrupted by reflected radio emission from Earth. In particular, there is an abrupt increase in the observed flux density of the Moon within the internationally recognized frequency modulated (FM) radio band. The observations have implications for future low-frequency surveys and EoR detection experiments that will need to take this reflected emission from the Moon into account. The results also allow us to estimate the equivalent isotropic power emitted by the Earth in the FM band and to determine how bright the Earth might appear at meter wavelengths to an observer beyond our own solar system.National Science Foundation (U.S.) (Grant AST-0457585)National Science Foundation (U.S.) (Grant AST-0908884)National Science Foundation (U.S.) (Grant PHY-0835713)United States. Air Force Office of Scientific Research (Grant FA9550-0510247)Smithsonian Astrophysical ObservatoryMIT School of Scienc

The giant lobes of Centaurus A observed at 118 MHz with the Murchison Widefield Array

We present new wide-field observations of Centaurus A (Cen A) and the surrounding region at 118 MHz with the Murchison Widefield Array (MWA) 32-tile prototype, with which we investigate the spectral-index distribution of Cen A's giant radio lobes. We compare our images to 1.4 GHz maps of Cen A and compute spectral indices using temperature–temperature plots and spectral tomography. We find that the morphologies at 118 MHz and 1.4 GHz match very closely apart from an extra peak in the southern lobe at 118 MHz, which provides tentative evidence for the existence of a southern counterpart to the northern middle lobe of Cen A. Our spatially averaged spectral indices for both the northern and southern lobes are consistent with previous analyses, however we find significant spatial variation of the spectra across the extent of each lobe. Both the spectral-index distribution and the morphology at low radio frequencies support a scenario of multiple outbursts of activity from the central engine. Our results are consistent with inverse-Compton modelling of radio and gamma-ray data that support a value for the lobe age of between 10 and 80 Myr.National Science Foundation (U.S.) (Grant AST-0457585)National Science Foundation (U.S.) (Grant PHY-0835713)National Science Foundation (U.S.) (Grant CAREER-0847753)National Science Foundation (U.S.) (Grant AST-0908884)United States. Air Force Office of Scientific Research (Grant FA9550-0510247)Smithsonian Astrophysical ObservatoryMIT School of Scienc