Functional vs. Traditional Resistance Training: Affective Response and Exercise Enjoyment in College-Age Females

As young women enter college-age, their rates of physical activity decrease while rates of psychological distress increase. Resistance training (RT) has been shown to have positive effects on the musculoskeletal system, glucose metabolism, body fat, insulin resistance, blood pressure, resting metabolic rate and psychological health. Within the types of RT, there is increased interest in functional resistance training (FRT), which uses multi-joint full-body movements; however few studies have been conducted to date examining FRT in college-aged females. Preliminary evidence indicates FRT leads to increases in fitness and may address the barriers common to traditional RT including embarrassment, enjoyment and concerns of masculinity. The purpose of this study is to compare affective responses, enjoyment, and self-efficacy between FRT and traditional resistance training (TRT) in college-age females. A randomized crossover experimental design in which each participant will experience both types of training in a random order is being conducted. Thirty-four females will be recruited to complete 2 sessions for each type of training, including a familiarization session where they will perform a 10-repetition maximum (RM) test for 8 exercises, followed by an assessment session with 2 sets of 10 repetitions for each exercise. Statistical analysis will include correlational test and paired t-tests to assess relationships between type of training and outcome variables of interest. It is hypothesized that females will experience greater enjoyment, positive affect and self-efficacy as well as decreased state anxiety in the FRT group as compared to the TRT group. Data collection is currently underway and preliminary results will be reported

Weight loss in persons with serious mental illness

Comment on A behavioral weight-loss intervention in persons with serious mental illness. [N Engl J Med. 2013

Body Image Quality of Life Related to Light Physical Activity and Sedentary Behavior among Young Adults with Overweight/Obesity

Sedentary behaviors, low levels of physical activity (PA), and low body image quality of life have been identified during college years and associated with poor health outcomes. Public health efforts have recently focused on decreasing sedentary time by increasing light physical activity, both of which have been associated with body image quality of life, though mainly through self-report. In this cross-sectional study, we examined objective actigraphy and survey data from 404 of 459 young adults with overweight and obesity (mean age 23.3 +/- 4.4 years, 78.4% female, 55.4% white). PA was measured using an accelerometer worn during waking hours for \u3e 10 h/day for four days. Body image quality of life was assessed using the Body Image Quality of Life Inventory Scale. Body image was positively correlated with light PA (r = 0.15) and inversely correlated with BMI (Pearson\u27s r = -0.20) and sedentary time (r = -0.10), but not moderate PA, vigorous PA, or MVPA. Light PA and sedentary time were significantly inversely correlated (r = -0.38). When controlling for covariates, higher body image quality of life was significantly associated with higher levels of light PA (beta = 0.39; p \u3c 0.01) and lower sedentary time (beta = -0.39; p = 0.02). Participants with lower body image quality of life enrolled in weight loss interventions may benefit from prescriptions of light PA in conjunction with decreasing sedentary behaviors

HORIZON Center: Promoting Health and Health Equity in Inner Boston

The HORIZON Center is an Exploratory Center of Excellence (COE) funded by a grant from the National Institute on Minority Health and Health Disparities (NIMHD). Our mission is to improve minority health and promote health equity through research, research training, and community engagement. Like other COEs, HORIZON is organized into four core areas: research, research training, community engagement, and administration. However, we work to promote collaboration and integration across core areas

Comparison of KRAS Mutation Assessment in Tumor DNA and Circulating Free DNA in Plasma and Serum Samples

Testing for mutations in the KRAS oncogene for patients with metastatic colorectal cancer (mCRC) is generally performed using DNA from formalin-fixed paraffin-embedded tumor tissue; however, access to specimens can be limited and analysis challenging. This study assessed the identification of KRAS mutations in circulating free DNA (cfDNA) using a commercially available KRAS polymerase chain reaction (PCR) kit. Matched plasma, serum and tumor samples were available from 71 patients with mCRC who had received prior therapy but whose disease progressed following therapy. Yields of cfDNA from plasma and serum samples were comparable. Analyses were successful in 70/71 plasma-extracted samples (specificity: 97%, sensitivity: 31%) and 67/71 serum- extracted samples (specificity: 100%, sensitivity: 25%). This study demonstrates that KRAS mutations can be detected in cfDNA using a commercially available KRAS PCR kit, confirming cfDNA as a potential alternative source of tumor DNA in a diagnostic setting if access to archival tumor specimens is limited

Conditions under which glutathione disrupts the biofilms and improves antibiotic efficacy of both ESKAPE and NON-ESKAPE species

Bacterial antibiotic resistance has increased in recent decades, raising concerns in hospital and community settings. Novel, innovative strategies are needed to eradicate bacteria, particularly within biofilms, and diminish the likelihood of recurrence. In this study, we investigated whether glutathione (GSH) can act as a biofilm disruptor, and enhance antibiotic effectiveness against various bacterial pathogens. Biological levels (10 mM) of GSH did not have a significant effect in inhibiting growth or disrupting the biofilm in four out of six species tested. However, exposure to 30 mM GSH showed >50% decrease in growth for all bacterial species, with almost 100% inhibition of Streptococcus pyogenes and an average of 94–52% inhibition for Escherichia coli, Methicillin-resistant Staphylococcus aureus (MRSA) and Methicillin-sensitive S. aureus (MSSA) and multi-drug resistant Acinetobacter baumannii (MRAB) isolates, respectively. Klebsiella pneumoniae and Enterobacter sp. isolates were however, highly resistant to 30 mM GSH. With respect to biofilm viability, all species exhibited a >50% decrease in viability with 30 mM GSH, with confocal imaging showing considerable change in the biofilm architecture of MRAB isolates. The mechanism of GSH-mediated biofilm disruption is possibly due to a concentration-dependent increase in GSH acidity that triggers cleaving of the matrix components. Enzymatic treatment of MRAB revealed that eDNA and polysaccharides are essential for biofilm stability and eDNA removal enhanced amikacin efficiency. Combination of GSH, amikacin and DNase-I showed the greatest reduction in MRAB biofilm viability. Additionally, GSH alone and in combination with amikacin fostered human fibroblast cell (HFF-1) growth and confluence while inhibiting MRAB adhesion and colonization

Predicting Mobile Mental Telehealth Usability Based on Individual Differences

Due to the increased need for the delivery of successful mental health interventions in special populations (i.e., military personnel, rural populations, aging populations, etc.), mobile mental telehealth applications have been developed to supplement patient-practitioner interaction. While there is a great deal of work on both patient and practitioner satisfaction with mobile mental telehealth devices, little is known about the influence of individual differences on user perceptions of usability and usefulness. The present study seeks to better predict the usability of mobile mental telehealth applications by drawing from the Technology Acceptance Model (Davis & Venkatesh, 1996; Venkatesh & Davis, 2000; Venkatesh, 2000) and self-determination theory literature (Deci, Eghrari, Patrick, & Leone, 1994; Ryan & Deci, 2001; Ryan & Deci, 2000). Eighty undergraduate students participated in a usability study examining the perceived ease of use of two free-to-download mobile mental telehealth applications. In this experiment, participants completed a series of surveys related to attitudes towards mental telehealth applications, motivation to use mental telehealth technology, and a brief demographic survey after interacting with the mental telehealth applications. A stepwise regression with an adjusted R2 value of .41 indicated that a little less than half of the variability in perceived mental telehealth application usability is predicted by user competence, user attitudes toward telehealth technology, and user goals for the system. The implications of these findings will be discussed further, as well as the limitations of this study

Increasing Physical Activity in Inner City Youth Using Novel Interactive Gaming

The aim of this project was to assess the feasibility of participation in an afterschool physical activity program incorporating novel exercise technologies on changing physical activity level and physical fitness, compared to a nutrition education intervention alone. A second objective was to assess whether this type of intervention could modify cardiovascular risk factors and anthropometrics

Prevalence of programmed death ligand-1 (PD-L1) by demographic, disease and sample characteristics in unresectable, stage III NSCLC (PACIFIC)

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Long-term geoelectrical monitoring of landslides in natural and engineered slopes

Developments in time-lapse electrical resistivity tomography (ERT) technology are transforming our ability to monitor the subsurface due to purpose-built monitoring instruments, advances in automation and modeling, and the resulting improvements in spatial and temporal resolution. We describe the development of a novel ERT-based remote monitoring system called PRIME that integrates new low-power measurement instrumentation with data delivery, automated data processing and image generation, and web-based information delivery. Due to the sensitivity of ERT to hydrologic processes in the near surface, we focus on the application of PRIME for moisture-driven landslide monitoring. Case examples are considered of landslides in engineered and natural slopes, including those impacting geotechnical assets in rail and highways, where slope hydrology is seen to be controlled by lithology, vegetation, fissuring, and drainage structures. We conclude by taking a forward look at emerging developments in ERT monitoring relating to hardware, software and modeling, and applications