3 research outputs found
Hair Follicle Dermal Cells Support Expansion of Murine and Human Embryonic and Induced Pluripotent Stem Cells and Promote Haematopoiesis in Mouse Cultures
- Author
- Publication venue
- Hindawi
- Publication date
- 01/01/2018
- Field of study
In the hair follicle, the dermal papilla (DP) and dermal sheath (DS) support and maintain proliferation and differentiation of the epithelial stem cells that produce the hair fibre. In view of their regulatory properties, in this study, we investigated the interaction between hair follicle dermal cells (DP and DS) and embryonic stem cells (ESCs); induced pluripotent stem cells (iPSCs); and haematopoietic stem cells. We found that coculture of follicular dermal cells with ESCs or iPSCs supported their prolonged maintenance in an apparently undifferentiated state as established by differentiation assays, immunocytochemistry, and RT-PCR for markers of undifferentiated ESCs. We further showed that cytokines that are involved in ESC support are also expressed by cultured follicle dermal cells, providing a possible explanation for maintenance of ES cell stemness in cocultures. The same cytokines were expressed within follicles in situ in a pattern more consistent with a role in follicle growth activities than stem cell maintenance. Finally, we show that cultured mouse follicle dermal cells provide good stromal support for haematopoiesis in an established coculture model. Human follicular dermal cells represent an accessible and readily propagated source of feeder cells for pluripotent and haematopoietic cells and have potential for use in clinical applications
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro Carà Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Aquino Maia
- Arabi Yaseen M.
- Arachchige Malka
- Aravindan Latha
- Arbane Gill
- Archambault Patrick
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Arnott Andrew
- Arora Anand
- Aryal Diptesh
- Asghar Adeeba
- Asif Namra
- Aspinwall Angelique
- Attokaran Antony
- Attwood Ben
- Au Carly
- Audry Mathilde
- Austin Karen
- Austin Pauline
- Auvet Adrien
- Avard Bronwyn
- Awan Sidra
- Ayee Robert
- Azaiz Amine
- Azzaui Harun
- Babu Suresh
- Bacon Gina
- Badalamenti Salvatore
- Badie Julio
- Bagavathy Kavitha
- Bagot Catherine
- Bagshaw Sean
- Baig Nadia
- Baikady Ravishankar
- Bailey Lucy
- Baillie Kenneth
- Bain William
- Baker Alice
- Baker Evelyn
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- Bakthavatsalam Dhanalakshmi
- Balaie Morteza
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- Bariola Ryan
- Barker Gareth
- Barker Stephanie
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- Wright Kim
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- Xavier Kugan
- Yamagishi Yoshiaki
- Yamashita Chizuru
- Yang Yang
- Yarad Elizabeth
- Yates Bryan
- Yates David
- Yealy Donald
- Young Ian
- Young Meredith
- Young Paul
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- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
Critical care admission following elective surgery was not associated with survival benefit: prospective analysis of data from 27 countries
- Author
- A T Landers
- Aaron Lawson McLean
- Abbey Paton
- Abdel Razzaq Khalaf
- Abdul Hafiz Alias
- Abdurrahman Ahmad
- Abegail Salvana
- Abigail Keen
- Abigail Patrick
- Abraham Hulst
- Acela G Lopez
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- Adamu Muhammad Sarki
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- Rong Hu
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- Rory Riddell
- Rosanna Greaves
- Rosanna Varden
- Rose Damant
- Rose English
- Roshan Rao
- Rosie Dudson
- Ross Cruickshank
- Ross Kennedy
- Ross Kerridge
- Rotimi Peter Olonisakin
- Rubendraj R Chetty
- Rubeshan Naidoo
- Rudy Harris
- Rui Freitas Mendonça Correia da Silva
- Rui Moreno
- Rui Moreno
- Rui Xue
- Ruilin Zhang
- Rune Sarauw Lundsgaard
- Rupert Broomby
- Rupert M Pearse
- Rupert M. Pearse
- Rusnah Ab Rahman
- Russ Hewson
- Russell Hewson
- Ruth Argue
- Ruvashni Naidoo
- Ryan Humphries
- Ryan Salter
- Sabah Al Hussaini
- Sabine Ethgen
- Safauldeensalem Albaj
- Sahayam Santa
- Sahely Flores Risco
- Saiful Aizar Kesut
- Sailaja Pothuneedi
- Sailaja Pothuneedi
- Salim Tayeh
- Sally Anne Pearson
- Sally Humphreys
- Sally Wright
- Salome Cruz
- Salvador Fernández
- Sam Montasser
- Sam Papadopoullos
- Samantha Allen
- Samantha Keenan
- Sameer Garg
- Sameer Somanath
- Samir Patel
- Samson Tou
- Samuel Denham
- Sanda Maria Copotoiu
- Sandeep Varma
- Sandra Dias
- Sandra Holmström
- Sandra Jumbe
- Sanghamitra Mishra
- Sanjay Shah
- Sanjeev Garg
- Santiago Garcia Del Valle
- Saoirse Lyons
- Sara Jane Allen
- Sara Lyckner
- Sara Pick
- Sara Pick
- Sara Rêgo
- Sara Scott
- Sarah Ali
- Sarah Bates
- Sarah Bowrey
- Sarah Buckley
- Sarah Cavanagh
- Sarah Cooper
- Sarah Craw
- Sarah Harris
- Sarah James
- Sarah Mills
- Sarah Moreton
- Sarah Rasip
- Sarah Scourfield
- Sarah Welsh
- Sarah Williams
- Satwant Gill
- Satwant Kaur
- Saul Sundayi
- Saul Velaz Dominguez
- Savino Spadaro
- Scott Beattie
- Scott Beattie
- Scott Beattie
- Scott Nicol
- Sean Mcmullan
- Sebastian Tranca
- Seigne Richard
- Seleen Cheah
- Selina Sewpersad
- Semarawima Wima
- Serge Molliex
- Sergey Puzanov
- Sergi Tormo
- Shafa Ullah
- Shailendra Sham
- Shalil Solanki
- Shan Luo
- Shane McQuoid
- Shanglong Yao
- Shantal Deepak
- Shara McDonald
- Shardha Chandrasekharan
- Sharif Darwish
- Sharon Cacala
- Sharon Cotterell
- Shasha Chen
- Shashikant Yegnaram
- Shaun Naidoo
- Sheba Predeep
- Shelley Baillie
- Sheng Wang
- Shenhui Jin
- Shenhui Wang
- Sheraz Markar
- Sherezade Tovar Doncel
- Sheshagiri Bengeri
- Sheshendrasurian Visvalingam
- Shihai Zhang
- Shilpaja Karpate
- Shirley Pyke
- Shiv Chande
- Shiva Tripathi
- Shiva Tripathi
- Shixia Xu
- Shiyu Chen
- Shobhit Arya
- Shu Kai Ma
- Shuangfei Hu
- Shuangjia Yang
- Shuchi Kaushik
- Shuchun Yu
- Shuijing Wu
- Shun Wang
- Shuna Zhao
- Shuying Fu
- Si Yuan Dai
- Sian Gallard
- Sian Thomas
- Sibongile J Mothae
- Siegfried Veit
- Siew Ching Tan
- Sigismond Lasocki
- Sijia Chen
- Silvano Cardellino
- Silvia Martín
- Silvia Sanchez-Morcillo
- Simao Esteves
- Simeon Olateju
- Simon Bisgaard Heintzelmann
- Simon Chau
- Simon Davis
- Simon Hill
- Simon Large
- Simon Lawson
- Simon Lewthwaite
- Simon Nørgaard Granum
- Simon Pickard
- Simon Varley
- Simona Margarit
- Simone Haselberger
- Sindiswa Ntloko
- Sinead Kelly
- Siobhan Hoare
- Sofia Kokkini
- Sofia Marques
- Sofia Serra
- Solange R Nahum
- Somasundaram Jeyanthan
- Song Huang
- Sonia Sampson
- Sonja Meier
- Sonya Daniel
- Sophia Tsiligiannis
- Sophie Gray
- Sophie Mathoulin
- Sotannde Sola
- Sotirios Bristogiannis
- Sotirios Georgios Popeskou
- Speranza Bocchino
- Spyros Zakynthinos
- Srikanth Chukkambotla
- Stanislav Pugachev
- Stavros Tsampalas
- Stefaan Bouchez
- Stefan Angermair
- Stefan Breitenstein
- Stefan de Hert
- Stefan De Hert
- Stefan Wildi
- Stephan Holliger
- Stephan Thilen
- Stephanie Bell
- Stephanie Jones
- Stephen Barrett
- Stephen Choi
- Stephen John Roberts
- Stephen Kowalski
- Stephen P Blakemore
- Stephen Phillips
- Stephen Webb
- Stephens Robert
- Steve Rose
- Steve White
- Steven Kim
- Steven Kleopoulos
- Steven Takemoto
- Steyn van Wyk
- Stuart White
- Stylianos Gaitanakis
- Stylianos Karatzas
- Stéphane de Rudnicki
- Su Meng
- Subash Chirkut
- Sudha Bechan
- Sudheer Karlakki
- Sue Hesketh
- Sue Olliff
- Suhas Kumar
- Sujith Basanth
- Sukhada Savarkar
- Sukumar Nagaiah
- Suman Mewa Kinoo
- Sumara Niman
- Sumayer Sanghera
- Sumitra Lahiri
- Suneetha Venugopal
- Sunny Karadia
- Suparna Das
- Suren R Ramphal
- Susan Melbourne
- Susan Smolen
- Susanna Chu
- Susanne Sonnemann
- Susanne Sonnemann
- Susilo Chandra
- Susilo Chandra
- Suwayba Adam
- Suzana Lobo
- Suzana M Lobo
- Suzanne Coulter
- Suzanne Odeberg-Wernerman
- Svenja Pabel
- Swarna Arumugam
- Swarna Baskar Sharma
- Swati Karmarkar
- Swati Pande
- Sze Meng Wong
- Sérgio Baldisserotto
- Søren Hübertz Smith
- Taeyang Kim
- Tahania Ahmad
- Tahania Ahmed
- Talvinder Gill
- Tamara Brunete
- Tamas Szakmany
- Tamas Szakmany
- Tanaka Muzenda
- Tania Socorro Artiles
- Tara Campbell
- Tara Walker
- Tarek Bejia
- Tariq Deen
- Tatiana Lefaki
- Tatiana Slepova
- Tauqeer Husain
- Tejal Dave
- Temlett Emma
- Tengku Alini Tengku Lih
- Teresa Branco
- Teresa Rotunno
- Terry Martin
- Tesuven K Naidu
- Thais Creary
- Thalissa Hermínia Baio
- Thandinkosi E Madiba
- Thelma Commey
- Theodora Christodoulopoulou
- Theodora Melissopoulou
- Theodosios Theodosopoulos
- Theoniki Paraforou
- Theonymfi Papavasilopoulou
- Theophilos Rozenberg
- Thiago Motta Netto
- Thinagrin Dhasarthun Naidoo
- Thomas Bührer
- Thomas Daubeny
- Thomas Egan
- Thomas Hillermann
- Thomas Hopkins
- Thomas Hughes
- Thomas Jared McCormick
- Thomas Jared McCormick
- Thomas Mayrhofer
- Thomas McCormick
- Thomas Mencke
- Thomas Owen
- Thomas Parsons
- Thomas Smith
- Thuli Biyase
- Tiago do Nascimento Cabral
- Tian Yu
- Tianlong Wang
- Tianqin Yang
- Tianzhao Zheng
- Tim Cook
- Tim Short
- Timothy Jones
- Timothy McCulloch
- Timothy Salmond
- Tina Kobborg
- Ting Zhao
- Tingju Hu
- Tinuolac Adigun
- Tjokorda Gde Agung Senapathi
- Tokunbo Olajumoke
- Tom Abbott
- Tom Burrows
- Tom Jacobs
- Tom Jowitt
- Tom Lawson
- Tom Lawton
- Tom van Zundert
- Tonia Onyeka
- Tony Smith
- Tony Wong
- Tracey Hodgkiss
- Tracey Lowery
- Tracey Nolan
- Tracey Nolan
- Tracey Roberts
- Tracy Lam
- Tracy Norton
- Tracy-Lee Jansen
- Tressy Pitt-Kerby
- Troy Wildes
- Tse Siang Tan
- Tunde Osinaike
- Ucu Nurhadiat Abidin
- Ulf Kessler
- Ulrich Goebel
- Ulrika Winstone
- Uma Shastri
- Umar Musa Sule
- Ummi Azmira Ahmad Azam
- Urs Zingg
- Utara Hartawan Utara
- Vaia Aliki Rompou
- Valentin Tutunaru
- Valentina Paola Plumari
- Valentina Testa
- Valentina Tulupova
- Valerie Banner-Goodspeed
- Valerie Serra Maudet
- Valerie Smit-Fun
- Valeriy Levin
- Vandana Agarwal
- Vanessa Beavis
- Vanessa Beavis
- Vanessa Beavis
- Vanessa Nesbitt
- Varvara Vanessa Gardikou
- Vasileia Nyktari
- Vasileios Despotidis
- Vasileios Kalles
- Vasileios Ourailoglou
- Vasilios Bouris
- Vasilios Koulouras
- Veerle Van Mossevelde
- Vera Guttenthaler
- Veronica Cherrett
- Veronika Cakova
- Vicari Sottosanti
- Vicente Chisbert Cuenca
- Vicky Hills
- Victor Anillo
- Victor Aspelund Liljequist
- Victor Ionita
- Victor Raji
- Victoria Bennett
- Victoria Boggiano
- Victoria Freeman
- Victoria Frost
- Victoria Lambourne
- Victoria Martinson
- Victoria Phelps
- Vieri Parrini
- Vikas Kaura
- Vilavan Koompirochana
- Vimal Hariharan
- Vincent Chan
- Vineshykaa Ramesh Kumar
- Vinícius Nascimento
- Vishal Narwani
- Vishendran Govindasamy
- Vivek Sinha
- Vivesh Rughubar
- Vlad Kushakovsky
- Vladimir Kretov
- Vladislav Belskiy
- Vukani T Manzini
- Vítor Miguel Pinho-Oliveira
- Wai Cheong Soon
- Wai Kit Jacky Chan
- Wangpin Xiao
- Warren Paul Kuhn
- Wei Ren
- Wei Xiao
- Weihong Zhao
- Weilin Sung
- Weilu Zhao
- Weiwei Zhang
- Weixing Wang
- Wendy Bertram
- Wendy Joan Barrett
- Weng Ken Chan
- Wenhui Huang
- Werner Schmid
- Werner Schmid
- Weslley Mendes
- Widnyana Made Wid
- William Almeida
- William Foers
- William Peat
- Wilson Binh Quan Huynh
- Wilson Fabio Serna Martínez
- Wilton van Klei
- Wing LamWong
- Wing Sze Li
- Wing Yan Lam
- Wiryana Made Wir
- Wolfgang Buhre
- Wolfgang Buhre
- Wujun Geng
- Xenia Souvatzis
- Xian-Jin Zhou
- Xianfu Lu
- Xiangming Fang
- Xianwen Hu
- Xiao Hong Wen
- Xiaocui Lv
- Xiaodong Ge
- Xiaodong Qiu
- Xiaoguang Zhang
- Xiaohua Zou
- Xiaolan Hu
- Xiaolin Zhang
- Xiaomao Zhu
- Xiaoqin Li
- Xiaoyan Zhang
- Xiaoying Li
- Xiaoying Zhao
- Xiaoyu Li
- Xiaoyun Shi
- Xiapei Xiong
- Xin He
- Xindan Du
- Xinjian Lu
- Xinmei Jiang
- Xinyu Qi
- Xiu-Li Wang
- Xiumei Song
- Xiuxiu Zhuang
- Xuewu Lin
- Xuming Hu
- Yan Jing
- Yan Leng
- Yan Pan
- Yan Zhang
- Yana Ilyina
- Yanbing Bi
- Yanfei Xia
- Yang Liu
- Yang Yang
- Yangwen Ou
- Yangyang Han
- Yanling Li
- Yanming Huang
- Yanqiu Ai
- Yapping Zhang
- Yaqi Li
- Yaqiu Chen
- Yassr Al-Soudaine
- Yavor Metodiev
- Yazhou Wen
- Yazhuo Yuan
- Ye Zhang
- Yelong Ren
- Yemi Adelaja
- Yetong Li
- Yew Ching Lee
- Yi Liu
- Yi Zhong
- Yi Zhu
- Yijiao Chen
- Yijun Chen
- Yik Lam Chan
- Ying Cao
- Yingfen Xiong
- Yingping Liang
- Yixiu Yan
- Yiyi Shi
- Yonghao Yu
- Yongjie Chen
- Yongqing Guo
- Yongtao Sun
- Yongzhong Tang
- Yoni van Duivenvoorde
- Youliang Tong
- Yousif Saeed
- Yousra Ahmad
- Yu Fan
- Yu Sun
- Yuan Hsuan Chang
- Yuan Liang Woon
- Yuan Zhang
- Yuanming Pan
- Yuanyuan Pan
- Yue Fei
- Yuehong Qi
- Yuejiang Liu
- Yuelan Wang
- Yugang Shi
- Yuhong Li
- Yuksel Gercek
- Yun Bai
- Yun Ren
- Yunbin Fu
- Yunchang Mo
- Yunfei Cai
- Yunlin Feng
- Yunzhi Ling
- Yurui Yao
- Yushio Cheing
- Yusuf Ameer
- Yuting Wang
- Yves Jaquet
- Yvonne Hack
- Yvonne Selibea
- Zaheer Moolla
- Zaid Makzal
- Zane Farina
- Zhang Chen
- Zhen Dan Peng
- Zhen Wang
- Zhen Wang
- Zheng Guo
- Zhengyuan Liu
- Zhenrong Ji
- Zhi Wang
- Zhipeng Wang
- Zhipeng Zhu
- Zhisong Li
- Zhiting Wen
- Zhong-Yuan Xia
- Zhongming Cao
- Zi-Ying Shen
- Zin Nico
- Ziqiang Miao
- Zoe Davies
- Zoe Drinkwater
- Zoe Whitman
- Zulkarnain Hamzah
- Álvaro Réa-Neto
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
This was an investigator initiated study funded by Nestle Health Sciences through an unrestricted research grant, and by a National Institute for Health Research (UK) Professorship held by RP. The study was sponsored by Queen Mary University of London