Myocardial tissue characterization: histological and pathophysiological correlation

Cardiovascular magnetic resonance imaging (CMR) has become the gold standard not only for cardiac volume and function quantification, but for a key unique strength: non-invasive myocardial tissue characterization. Several different techniques, separately or in combination, can detect and quantify early and established myocardial pathological processes permitting better diagnosis, prognostication and tracking of therapy. The authors will focus on the histological and pathophysiological evidence of these imaging parameters in the characterization of edema, infarction, scar and fibrosis. In addition to laying out the strengths and weaknesses of each modality, the reader will be introduced to rapid developments in T1 and T2 mapping as well as the use of contrast-derived extracellular volume for quantification of diffuse fibrosis

Extracts From New Zealand Undaria Pinnatifida Containing Fucoxanthin As Potential Functional Biomaterials Against Cancer in Vitro

This study tested extracts from New Zealand seaweed Undaria pinnatifida containing fucoxanthin, in parallel with pure fucoxanthin, in nine human cancer cell lines, for anticancer activity. Growth inhibition effects of extracts from Undaria pinnatifida were found in all types of cancer cell lines in dose- and time- dependent manners. Cytotoxicity of fucoxanthin in three human non-cancer cell lines was also tested. Compared with pure fucoxanthin, our extracts containing low level of fucoxanthin were found to be more effective in inhibiting the growth of lung carcinoma, colon adenocarcinoma and neuroblastoma. Our results suggest that fucoxanthin is a functional biomaterial that may be used as a chemopreventive phytochemical or in combination chemotherapy. Furthermore, we show for the first time that some unknown compounds with potential selective anti-cancer effects may exist in extracts of New Zealand Undaria pinnatifida, and New Zealand Undaria pinnatifida could be used as a source for either functional biomaterial extraction or production of functional food

Does Faux Pas Detection in Adult Autism Reflect Differences in Social Cognition or Decision-Making Abilities?

43 typically-developed adults and 35 adults with ASD performed a cartoon faux pas test. Adults with ASD apparently over-detected faux pas despite good comprehension abilities, and were generally slower at responding. Signal detection analysis demonstrated that the ASD participants had significantly greater difficulty detecting whether a cartoon depicted a faux pas and showed a liberal response bias. Test item analysis demonstrated that the ASD group were not in agreement with a reference control group (n = 69) about which non-faux pas items were most difficult. These results suggest that the participants with ASD had a primary problem with faux pas detection, but that there is another factor at work, possibly compensatory, that relates to their choice of a liberal response criterion

Estimation of leaf area index in eucalypt forest with vertical foliage, using cover and fullframe fisheye photography

This study compared fullframe fisheye photography and cover photography with destructive leaf area index (L) estimation and the Licor LAI-2000 plant canopy analyser (PCA) in plantations of the vertical leaved species Eucalyptus globulus. Fullframe fisheye photography differs from circular fisheye photography in that the images have reduced field of view such that the zenithal range of 0-90° extends to the corners of the rectangular image, roughly doubling image resolution compared to circular images. Cover images instead are obtained by pointing a 70 mm equivalent focal length lens (in 35 mm format) straight upwards. Measurements of cover and indirect estimates of plant area index (Lt) were made in 12 stands of 6-8 years old Eucalyptus globulus. L was measured using destructive sampling and allometry in nine of these stands and ranged from 2.5 to 6.6. Both foliage cover and Lt from the PCA were well correlated with L from allometry, but fullframe fisheye photography provided poor estimates of L despite corrections for foliage clumping. Sampling location had a significant effect on estimates of crown porosity, crown cover and zenithal clumping index from cover photography. The zenithal extinction coefficient (k), calculated from L, crown porosity and cover, ranged from 0.14 to 0.25 and appeared to decrease as L increased; hence, we were unable to obtain an unambiguous estimate of k for E. globulus stands. Nonetheless, the study showed that L can be estimated from foliage cover with similar certainty to that of the PCA. We conclude that the greatest challenge facing indirect estimation of L in forests using photographic methods is to separate the effects of foliage angle from those of foliage clumping. © 2007 Elsevier B.V. All rights reserved

Anti-proliferation Potential and Content of Fucoidan Extracted From Sporophyll of New Zealand Undaria Pinnatifida

Undaria pinnatifida is a species of brown seaweed known to contain rich amounts of fucoidan, a sulfated polysaccharide known to possess various biological activities. We isolated crude fucoidan (F0) from the sporophylls of U. pinnatifida grown in the Marlborough Sounds, New Zealand. Sulfate content, uronic acid content, and molecular weight of F0 were 15.02, 1.24, and >150 kDa, respectively. F0 was fractionated to yield three further fractions: F1, F2, and F3. Cytotoxicity of two major fractions was determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The algal fucoidans specifically suppressed the proliferation of three cancer cell lines with less cytotoxicity against the normal cells. Selective cytotoxicity could relate to the distinctive structures of each fucoidan fraction. Results from this study provide evidence that fucoidan, especially from U. pinnatifida grown in New Zealand, possesses great potential to be used as a functional food to reduce cancer risk or supplement cancer treatment

Generalized Flows around Neutron Stars

In this chapter, we present a brief and non-exhaustive review of the developments of theoretical models for accretion flows around neutron stars. A somewhat chronological summary of crucial observations and modelling of timing and spectral properties are given in sections 2 and 3. In section 4, we argue why and how the Two-Component Advective Flow (TCAF) solution can be applied to the cases of neutron stars when suitable modifications are made for the NSs. We showcase some of our findings from Monte Carlo and Smoothed Particle Hydrodynamic simulations which further strengthens the points raised in section 4. In summary, we remark on the possibility of future works using TCAF for both weakly magnetic and magnetic Neutron Stars.Comment: 15 pages, 7 figures. arXiv admin note: text overlap with arXiv:1901.0084

No future, no kids–no kids, no future?: An exploration of motivations to remain childfree in times of climate change

Individuals around the world believe global climate change is a major threat, with media attention and polling suggesting young adults may decide to go childfree as a result. Yet, there is limited research on the link between environmental concern and reproductive attitudes. The purpose of this research was to explore how climate change-related concerns affect reproductive attitudes and motivations to remain childfree. Two studies were conducted: study 1 consisted of a content analysis of reader comments on articles discussing going childfree in response to climate change, and study 2 featured semi-structured interviews conducted in New Zealand and the USA. The impact of future children on the planet, in the context of overpopulation and overconsumption, was a major theme in both studies. Perspectives of doom and hope emerged simultaneously, indicating how climate anxiety influences reproductive attitudes. Study findings point at implications for public policy makers regarding this largely neglected perspective on climate change adaptation and mitigation and potential psychological and societal effects

Caseload midwifery compared to standard or private obstetric care for first time mothers in a public teaching hospital in Australia: A cross sectional study of cost and birth outcomes

Background: In many countries midwives act as the main providers of care for women throughout pregnancy, labour and birth. In our large public teaching hospital in Australia we restructured the way midwifery care is offered and introduced caseload midwifery for one third of women booked at the hospital. We then compared the costs and birth outcomes associated with caseload midwifery compared to the two existing models of care, standard hospital care and private obstetric care.Methods: We undertook a cross sectional study examining the risk profile, birth outcomes and cost of care for women booked into one of the three available models of care in a tertiary teaching hospital in Australia between July 1st 2009 December 31st 2010. To control for differences in population or case mix we described the outcomes for a cohort of low risk first time mothers known as the 'standard primipara'.Results: Amongst the 1,379 women defined as 'standard primipara' there were significant differences in birth outcome. These first time 'low risk' mothers who received caseload care were more likely to have a spontaneous onset of labour and an unassisted vaginal birth 58.5% in MGP compared to 48.2% for Standard hospital care and 30.8% with Private obstetric care (p < 0.001). They were also significantly less likely to have an elective caesarean section 1.6% with MGP versus 5.3% with Standard care and 17.2% with private obstetric care (p < 0.001). From the public hospital perspective, over one financial year the average cost of care for the standard primipara in MGP was $3903.78 per woman. This was$1375.45 less per woman than those receiving Private obstetric care and $1590.91 less than Standard hospital care per woman (p < 0.001). Similar differences in cost were found in favour of MGP for all women in the study who received caseload care.Conclusions: Cost reduction appears to be achieved through reorganising the way care is delivered in the public hospital system with the introduction of Midwifery Group Practice or caseload care. The study also highlights the unexplained clinical variation that exists between the three models of care in Australia. © 2014 Tracy et al.; licensee BioMed Central Ltd

Business process modelling and visualisation to support e-government decision making: Business/IS alignment

© 2017 Springer-Verlag. The final publication is available at Springer via https://doi.org/10.1007/978-3-319-57487-5_4.Alignment between business and information systems plays a vital role in the formation of dependent relationships between different departments in a government organization and the process of alignment can be improved by developing an information system (IS) according to the stakeholders’ expectations. However, establishing strong alignment in the context of the eGovernment environment can be difficult. It is widely accepted that business processes in the government environment plays a pivotal role in capturing the details of IS requirements. This paper presents a method of business process modelling through UML which can help to visualise and capture the IS requirements for the system development. A series of UML models have been developed and discussed. A case study on patient visits to a healthcare clinic in the context of eGovernment has been used to validate the models