Why stellar feedback promotes disc formation in simulated galaxies

We study how feedback influences baryon infall onto galaxies using cosmological, zoom-in simulations of haloes with present mass $M_{vir}=6.9\times10^{11} M_{\odot}$ to $1.7\times10^{12} M_{\odot}$. Starting at z=4 from identical initial conditions, implementations of weak and strong stellar feedback produce bulge- and disc-dominated galaxies, respectively. Strong feedback favours disc formation: (1) because conversion of gas into stars is suppressed at early times, as required by abundance matching arguments, resulting in flat star formation histories and higher gas fractions; (2) because 50% of the stars form in situ from recycled disc gas with angular momentum only weakly related to that of the z=0 dark halo; (3) because late-time gas accretion is typically an order of magnitude stronger and has higher specific angular momentum, with recycled gas dominating over primordial infall; (4) because 25-30% of the total accreted gas is ejected entirely before z~1, removing primarily low angular momentum material which enriches the nearby inter-galactic medium. Most recycled gas roughly conserves its angular momentum, but material ejected for long times and to large radii can gain significant angular momentum before re-accretion. These processes lower galaxy formation efficiency in addition to promoting disc formation.Comment: 23 pages, 29 figures, accepted for publication in MNRA

Junior Recital, Gabriel V. Taylor, guitar

The presentation of this junior recital will fulfill in part the requirements for the Bachelor of Music degree in Performance. Gabriel V. Taylor studies guitar with David Toussaint

Loss of Num1-mediated cortical dynein anchoring negatively impacts respiratory growth

Num1 is a multifunctional protein that both tethers mitochondria to the plasma membrane and anchors dynein to the cell cortex during nuclear inheritance. Previous work has examined the impact loss of Num1-based mitochondrial tethering has on dynein function in Saccharomyces cerevisiae; here, we elucidate its impact on mitochondrial function. We find that like mitochondria, Num1 is regulated by changes in metabolic state, with the protein levels and cortical distribution of Num1 differing between fermentative and respiratory growth conditions. In cells lacking Num1, we observe a reproducible respiratory growth defect, suggesting a role for Num1 in not only maintaining mitochondrial morphology, but also function. A structure–function approach revealed that, unexpectedly, Num1- mediated cortical dynein anchoring is important for normal growth under respiratory conditions. The severe respiratory growth defect in Δnum1 cells is not specifically due to the canonical functions of dynein in nuclear migration but is dependent on the presence of dynein, as deletion of DYN1 in Δnum1 cells partially rescues respiratory growth. We hypothesize that misregulated dynein present in cells that lack Num1 negatively impacts mitochondrial function resulting in defects in respiratory growth

Feedback and the Structure of Simulated Galaxies at redshift z=2

We study the properties of simulated high-redshift galaxies using cosmological N-body/gasdynamical runs from the OverWhelmingly Large Simulations (OWLS) project. The runs contrast several feedback implementations of varying effectiveness: from no-feedback, to supernova-driven winds to powerful AGN-driven outflows. These different feedback models result in large variations in the abundance and structural properties of bright galaxies at z=2. We find that feedback affects the baryonic mass of a galaxy much more severely than its spin, which is on average roughly half that of its surrounding dark matter halo in our runs. Feedback induces strong correlations between angular momentum content and galaxy mass that leave their imprint on galaxy scaling relations and morphologies. Encouragingly, we find that galaxy disks are common in moderate-feedback runs, making up typically ~50% of all galaxies at the centers of haloes with virial mass exceeding 1e11 M_sun. The size, stellar masses, and circular speeds of simulated galaxies formed in such runs have properties that straddle those of large star-forming disks and of compact early-type galaxies at z=2. Once the detailed abundance and structural properties of these rare objects are well established it may be possible to use them to gauge the overall efficacy of feedback in the formation of high redshift galaxies.Comment: 16 pages, 12 figures. Accepted for publication in MNRAS. Minor changes to match published versio

Evolution of the Ionizing Background and the Epoch of Reionization from the Spectra of z~6 Quasars

We study the process of cosmic reionization and estimate the ionizing background in the IGM using the Lyman series absorption in the spectra of the four quasars at 5.7<z<6.3 discovered by the SDSS. We derive the evolution of the ionizing background at high redshifts, using both semi-analytic techniques and cosmological simulations to model the density fluctuations in the IGM. The existence of the complete Ly alpha Gunn-Peterson trough in the spectrum of the z=6.28 quasar SDSS 1030+0524 indicates a photoionization rate Gamma_{-12} at z~6 lower than 0.08, at least a factor of 6 smaller than the value at z~3. The Ly beta and Ly gamma Gunn-Peterson troughs give an even stronger limit Gamma_{-12}<0.02 due to their smaller oscillator strengths, indicating that the ionizing background in the IGM at z~6 is more than 20 times lower than that at z~3. Meanwhile, the volume-averaged neutral hydrogen fraction increases from 10^{-5} at z~3 to >10^{-3} at z~6. At this redshift, the mass-averaged neutral hydrogen fraction is larger than 1%; the mildly overdense regions (delta > 3) are still mostly neutral and the comoving mean free path of ionizing photons is shorter than 8 Mpc. Comparison with simulations of cosmological reionization shows that the observed properties of the IGM at z~6 are typical of those in the era at the end of the overlap stage of reionization when the individual HII regions merge. Thus, z~6 marks the end of the reionization epoch. The redshift of reionization constrains the small scale power of the mass density fluctuations and the star forming efficiency of the first generation of objects.Comment: AJ accepted, 27 pages; minor change

The bidirectional association between sleep problems and autism spectrum disorder

Background: Sleep difficulties are prevalent in children with autism spectrum disorder (ASD). The temporal nature of the association between sleep problems and ASD is unclear because longitudinal studies are lacking. Our aim is to clarify whether sleep problems precede and worsen autistic traits and ASD or occur as a consequence o

Cognitive behaviour therapy versus counselling intervention for anxiety in young people with high-functioning autism spectrum disorders: a pilot randomised controlled trial

The use of cognitive-behavioural therapy (CBT) as a treatment for children and adolescents with autism spectrum disorder (ASD) has been explored in a number of trials. Whilst CBT appears superior to no treatment or treatment as usual, few studies have assessed CBT against a control group receiving an alternative therapy. Our randomised controlled trial compared use of CBT against person-centred counselling for anxiety in 36 young people with ASD, ages 12–18. Outcome measures included parent- teacher- and self-reports of anxiety and social disability. Whilst each therapy produced improvements inparticipants, neither therapy was superior to the other to a significant degree on any measure. This is consistent with findings for adults

Bioengineered lungs generated from human iPSCs‐derived epithelial cells on native extracellular matrix

The development of an alternative source for donor lungs would change the paradigm of lung transplantation. Recent studies have demonstrated the potential feasibility of using decellularized lungs as scaffolds for lung tissue regeneration and subsequent implantation. However, finding a reliable cell source and the ability to scale up for recellularization of the lung scaffold still remain significant challenges. To explore the possibility of regeneration of human lung tissue from stem cells in vitro, populations of lung progenitor cells were generated from human iPSCs. To explore the feasibility of producing engineered lungs from stem cells, we repopulated decellularized human lung and rat lungs with iPSC‐derived epithelial progenitor cells. The iPSCs‐derived epithelial progenitor cells lined the decellularized human lung and expressed most of the epithelial markers when were cultured in a lung bioreactor system. In decellularized rat lungs, these human‐derived cells attach and proliferate in a manner similar to what was observed in the decellularized human lung. Our results suggest that repopulation of lung matrix with iPSC‐derived lung epithelial cells may be a viable strategy for human lung regeneration and represents an important early step toward translation of this technology.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142929/1/term2589.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142929/2/term2589_am.pd