622 research outputs found
Hole Dispersions for Antiferromagnetic Spin-1/2 Two-Leg Ladders by Self-Similar Continuous Unitary Transformations
The hole-doped antiferromagnetic spin-1/2 two-leg ladder is an important
model system for the high- superconductors based on cuprates. Using the
technique of self-similar continuous unitary transformations we derive
effective Hamiltonians for the charge motion in these ladders. The key
advantage of this technique is that it provides effective models explicitly in
the thermodynamic limit. A real space restriction of the generator of the
transformation allows us to explore the experimentally relevant parameter
space. From the effective Hamiltonians we calculate the dispersions for single
holes. Further calculations will enable the calculation of the interaction of
two holes so that a handle of Cooper pair formation is within reach.Comment: 16 pages, 26 figure
Resuscitation and quantification of stressed Escherichia coli K12 NCTC8797 in water samples
The aim of this study was to investigate the impact on numbers of using different media for the enumeration of Escherichia coli subjected to stress, and to evaluate the use of different resuscitation methods on bacterial numbers. E. coli was subjected to heat stress by exposure to 55 °C for 1 h or to light-induced oxidative stress by exposure to artificial light for up to 8 h in the presence of methylene blue. In both cases, the bacterial counts on selective media were below the limits of detection whereas on non-selective media colonies were still produced. After resuscitation in non-selective media, using a multi-well MPN resuscitation method or resuscitation on membrane filters, the bacterial counts on selective media matched those on non-selective media. Heat and light stress can affect the ability of E. coli to grow on selective media essential for the enumeration as indicator bacteria. A resuscitation method is essential for the recovery of these stressed bacteria in order to avoid underestimation of indicator bacteria numbers in water. There was no difference in resuscitation efficiency using the membrane filter and multi-well MPN methods. This study emphasises the need to use a resuscitation method if the numbers of indicator bacteria in water samples are not to be underestimated. False-negative results in the analysis of drinking water or natural bathing waters could have profound health effects
Staggered dimer order in S=1/2 quantum spin ladder system with four spin exchange
We study the S=1/2 quantum spin ladder system with the four-spin exchange,
using density matrix renormalization group method and an exact diagonalization
method. Recently, the phase transition in this system and its universality
class are studied. But there remain controversies whether the phase transition
is second order type or the other type and the nature of order parameter. There
are arguments that the massless phase appears. But this does not agree with our
previous result. Analyzing DMRG data, we try a new approach in order to
determine a phase which appears after the phase transition. We find that the
edge state appears in the open boundary condition, investigating excitation
energies of states with higher magnetizations.Comment: Submitted to Phys. Rev. B, (REVTeX4
Spectral properties of the dimerized and frustrated chain
Spectral densities are calculated for the dimerized and frustrated S=1/2
chain using the method of continuous unitary transformations (CUTs). The
transformation to an effective triplon model is realized in a perturbative
fashion up to high orders about the limit of isolated dimers. An efficient
description in terms of triplons (elementary triplets) is possible: a detailed
analysis of the spectral densities is provided for strong and intermediate
dimerization including the influence of frustration. Precise predictions are
made for inelastic neutron scattering experiments probing the S=1 sector and
for optical experiments (Raman scattering, infrared absorption) probing the S=0
sector. Bound states and resonances influence the important continua strongly.
The comparison with the field theoretic results reveals that the sine-Gordon
model describes the low-energy features for strong to intermediate dimerization
only at critical frustration.Comment: 21 page
Antineutrinos from Earth: A reference model and its uncertainties
We predict geoneutrino fluxes in a reference model based on a detailed
description of Earth's crust and mantle and using the best available
information on the abundances of uranium, thorium, and potassium inside Earth's
layers. We estimate the uncertainties of fluxes corresponding to the
uncertainties of the element abundances. In addition to distance integrated
fluxes, we also provide the differential fluxes as a function of distance from
several sites of experimental interest. Event yields at several locations are
estimated and their dependence on the neutrino oscillation parameters is
discussed. At Kamioka we predict N(U+Th)=35 +- 6 events for 10^{32} proton yr
and 100% efficiency assuming sin^2(2theta)=0.863 and delta m^2 = 7.3 X 10^{-5}
eV^2. The maximal prediction is 55 events, obtained in a model with fully
radiogenic production of the terrestrial heat flow.Comment: 24 pages, ReVTeX4, plus 7 postscript figures; minor formal changes to
match version to be published in PR
Magnetic field diagnostics and spatio-temporal variability of the solar transition region
Magnetic field diagnostics of the transition region from the chromosphere to
the corona faces us with the problem that one has to apply extreme UV
spectro-polarimetry. While for coronal diagnostic techniques already exist
through infrared coronagraphy above the limb and radio observations on the
disk, for the transition region one has to investigate extreme UV observations.
However, so far the success of such observations has been limited, but there
are various projects to get spectro-polarimetric data in the extreme UV in the
near future. Therefore it is timely to study the polarimetric signals we can
expect for such observations through realistic forward modeling.
We employ a 3D MHD forward model of the solar corona and synthesize the
Stokes I and Stokes V profiles of C IV 1548 A. A signal well above 0.001 in
Stokes V can be expected, even when integrating for several minutes in order to
reach the required signal-to-noise ratio, despite the fact that the intensity
in the model is rapidly changing (just as in observations). Often this
variability of the intensity is used as an argument against transition region
magnetic diagnostics which requires exposure times of minutes. However, the
magnetic field is evolving much slower than the intensity, and thus when
integrating in time the degree of (circular) polarization remains rather
constant. Our study shows the feasibility to measure the transition region
magnetic field, if a polarimetric accuracy on the order of 0.001 can be
reached, which we can expect from planned instrumentation.Comment: Accepted for publication in Solar Physics (4.Mar.2013), 19 pages, 9
figure
A-dependence of nuclear transparency in quasielastic A(e,e'p) at high Q^2
The A-dependence of the quasielastic A(e,e'p) reaction has been studied at
SLAC with H-2, C, Fe, and Au nuclei at momentum transfers Q^2 = 1, 3, 5, and
6.8 (GeV/c)^2. We extract the nuclear transparency T(A,Q^2), a measure of the
average probability that the struck proton escapes from the nucleus A without
interaction. Several calculations predict a significant increase in T with
momentum transfer, a phenomenon known as Color Transparency. No significant
rise within errors is seen for any of the nuclei studied.Comment: 5 pages incl. 2 figures, Caltech preprint OAP-73
A 46,XY female DSD patient with bilateral gonadoblastoma, a novel SRY missense mutation combined with a WT1 KTS splice-site mutation
Patients with Disorders of Sex Development (DSD), especially those with gonadal dysgenesis and hypovirilization are at risk of developing malignant type II germ cell tumors/cancer (GCC) (seminoma/dysgerminoma and nonseminoma), with either carcinoma in situ (CIS) or gonadoblastoma (GB) as precursor lesion. In 10-15% of 46,XY g
An IRAK1-PIN1 signalling axis drives intrinsic tumour resistance to radiation therapy
Drug-based strategies to overcome tumour resistance to radiotherapy (R-RT) remain limited by the single-agent toxicity of traditional radiosensitizers (for example, platinums) and a lack of targeted alternatives. In a screen for compounds that restore radiosensitivity in p53 mutant zebrafish while tolerated in non-irradiated wild-type animals, we identified the benzimidazole anthelmintic oxfendazole. Surprisingly, oxfendazole acts via the inhibition of IRAK1, a kinase thus far implicated in interleukin-1 receptor (IL-1R) and Toll-like receptor (TLR) immune responses. IRAK1 drives R-RT in a pathway involving IRAK4 and TRAF6 but not the IL-1R/TLR-IRAK adaptor MyD88. Rather than stimulating nuclear factor-ÎşB, radiation-activated IRAK1 prevented apoptosis mediated by the PIDDosome complex (comprising PIDD, RAIDD and caspase-2). Countering this pathway with IRAK1 inhibitors suppressed R-RT in tumour models derived from cancers in which TP53 mutations predict R-RT. Moreover, IRAK1 inhibitors synergized with inhibitors of PIN1, a prolyl isomerase essential for IRAK1 activation in response to pathogens and, as shown here, in response to ionizing radiation. These data identify an IRAK1 radiation-response pathway as a rational chemoradiation therapy target
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