Embedding realistic surveys in simulations through volume remapping

Connecting cosmological simulations to real-world observational programs is often complicated by a mismatch in geometry: while surveys often cover highly irregular cosmological volumes, simulations are customarily performed in a periodic cube. We describe a technique to remap this cube into elongated box-like shapes that are more useful for many applications. The remappings are one-to-one, volume-preserving, keep local structures intact, and involve minimal computational overhead.Comment: 4 pages, 4 figures. Companion material at http://mwhite.berkeley.edu/BoxRemap

Clean Air Act Mayhem: EPA’s Tailoring Rule Stitches Greenhouse Gas Emissions Into the Wrong Regulatory Fitting

Regardless of whether you believe that human activities cause or contribute to global warming, regulatory action seeking to mitigate the future consequences of climate change will impact the lives of every American. On January 2, 2011, U.S. Environmental Protection Agency ( EPA ) regulation of greenhouse gas emissions from stationary sources took effect. The EPA rule implementing this regulation is the conclusion, for the time being, of a sequence of recent judicial and administrative activities comparable to a regulatory domino effect. The Supreme Court started the cascade of regulation in Massachusetts v. EPA, in which the Court held that the EPA has the authority to regulate greenhouse gas emissions under the Clean Air Act if further evaluation indicated greenhouse gases were endangering public health and mobile sources were contributing to the threat. Under President Obama\u27s guidance, the EPA finalized that Endangerment Finding and concluded human health was threatened by greenhouse gas emissions from mobile sources. Subsequently, the EPA published three codependent directives to regulate greenhouse gases under the Clean Air Act: (1) the Tailpipe Rule to regulate emissions from mobile sources; (2) an official interpretation of the Clean Air Act, concluding that when greenhouse gases are actually regulated under the Tailpipe Rule, stationary sources are also subject to regulation; and (3) the Tailoring Rule, a revision of statutory thresholds aimed at shielding small sources from rigorous Clean Air Act permitting requirements. In light of the unique challenges presented by global climate change, this Comment analyzes whether the EPA\u27s Tailoring Rule is lawful under existing statutory authority. According to the express language of the Clean Air Act, congressional intent underlying the statute, and legal precedent, the EPA\u27s Tailoring Rule represents an unauthorized expansion of EPA authority and is an arbitrary use of the Clean Air Act to regulate greenhouse gases. Because the Tailoring Rule violates the unambiguous language of the Clean Air Act, subverts the congressional intent underlying the Act, infringes upon the separation of legislative and executive powers, and relies improperly upon the disfavored legal doctrines, the Tailoring Rule should fail judicial review

Re-Establishing Food Retail in St. John, Kansas

Presenters lead a session that highlights a case study on developing a new grocery facility in a town of 1200 people. They describe what it took and the lessons learned, such as defining the size of the market; feasibility; and compensating when the market isn’t big enough to justify the investment they want from a public policy/town survival viewpoint. Some perspectives gained during the experience include conducting a market study; the value of a Citizen Committee; the real issue of population decline and job creation; how other businesses can be incorporated into the store (such as fuel, laundromat, liquor store, cell phone provider, etc.); the need for an experienced established operator; and what it takes to build a business and keep grocery stores going

Tributes to Professor Robert Berkley Harper

In 1977, I began teaching at The University of Pittsburgh Law School and in short order one of my closest friends during my tenure there was Professor Robert “Bob” Harper. I wondered when I was hired whether I was selected because I looked strikingly similar to Bob, and perhaps the faculty thought my favoring Professor Harper would make my assimilation into the law school faculty that much easier. Students constantly called me Professor Harper and, indeed, many on the faculty called me Bob for several years; I never bothered to correct them. I thought if they paid that little attention to detail in law school, I would just let them go through life missing some of the finer points their education, and life for that matter, has to offer

Cycles, wheels, and gears in finite planes

The existence of a primitive element of $GF(q)$ with certain properties is used to prove that all cycles that could theoretically be embedded in $AG(2,q)$ and $PG(2,q)$ can, in fact, be embedded there (i.e. these planes are `pancyclic'). We also study embeddings of wheel and gear graphs in arbitrary projective planes

Cariogenic Pathogens: One Less Thing To WINE About

Recently, studies have explored how biologically active compounds in wine benefit human teeth. Dietary polyphenols, in particular wine polyphenols, seem to balance the composition of the oral microbiota, thus leading to potentially more effective anti-carious effects on the individual. Recent research has discussed the main action mechanisms of polyphenols against oral microbial diseases and highlighted the antiadhesive capacity of caffeic and p-coumaric acids as well as grape seed and red wine extracts. It has been found that polyphenols increased their inhibition potential against S. mutans adhesion when combined with S. dentisani.¹ Other research regarding polyphenols, specifically resveratrol, discussed the anti-inflammatory effects of resveratrol and concluded that these polyphenols are effective against fighting cariogenic and periodontal disease pathogens. In conclusion, polyphenols in wine can have anti-carious effects. Because polyphenols have antiadhesive properties and antioxidant activity, this decreases the dental plaque accumulation in the oral cavity. The antiadhesive capacity in red wine polyphenols, in addition to complementary actions of an oral probiotic S. dentisani, increases the inhibition potential against S. mutans, thus concluding that wine polyphenols have an anti-carious effect and aid in the prevention of caries in the oral cavity.https://dune.une.edu/dh_studpost/1001/thumbnail.jp

Genre & écrans. L’intersectionnalité dans les séries télévisées et le cinéma anglophones

Continuing the RIN project “Genre & écrans,” l’Université Le Havre Normandie welcomed speakers from various disciplines to discuss notions of intersectionality in a plethora of British and American television series and films. These talks analyse the multi-layered representations of gender, race and class in the audiovisual fictions presented, as well as the real-world ideological implications anchored in British and American culture that these reflect. To begin the conference, first keynote ..

Characterization of TSG101 Induced Allostery within Glucocorticoid Receptor and Computational Drug-Lead Targeting of the Glucocorticoid Receptor DNA-Binding Domain

Glucocorticoid Receptor (GR) is a typical steroid hormone receptor. GR has a disordered N-terminal domain that binds transcriptional cofactors, a DNA-binding domain, and a steroid binding domain. Most work for the past forty years has been focused on the latter two domains that are structured and amenable to characterization. Yet, the disordered N-terminus makes up more than half of the protein and is absolutely required for transcriptional activation (repression can occur regardless). There are also translational isoforms with truncated N-termini that alter the resulting activity of GR. How the disordered isoforms of the N-terminus couple to cofactors and transcriptional activity is currently unclear. In this thesis, I sought organizing principles to explain the varying activities of GR translational isoforms. I found that a transcriptional cofactor, tumor susceptibility gene 101 (TSG101), can bind and fold the disordered N-terminus of GR. TSG101's binding is allosterically coupled to binding of DNA, but the exact mechanism differs between different isoforms of GR. In this thesis I also characterized the thermodynamic stability of the TSG101 coiled-coil, which binds GR, and I used computational docking to develop novel drug-leads targeted against the GR DNA-binding domain