Moans, Palpable Groin, and Entrapment of Bone: A Case of Malignant Peripheral Nerve Sheath Tumor in an otherwise Healthy Hispanic Male

Background: Malignant peripheral nerve sheath tumors (MPNTs) are rare malignant soft tissue sarcomas that have an incidence of about 0.001 %. MPNTs typically occur in individuals who have neurofibromatosis or secondary to radiation therapy and rarely occur sporadically. We present a case of a previously healthy 56-year-old gentleman who was diagnosed with MPNTs. Case: A healthy 56-year-old gentleman presented with worsening LLQ abdominal pain for 6 months. Associated symptoms included bloating, LLE swelling, early satiety for the past 2 months, and a 5-10lb unintentional weight loss. Patient denied recent cough, night sweats, dyspnea, fever, chills, melena or hematochezia. Vitals were WNL. Physical examination revealed a palpable mass on LLQ extending into the groin and edema of the left leg with diminished strength 3/5. CBC and CMP were unremarkable. CT abdomen showed a large necrotic mass in the left retroperitoneum infiltrating along the iliopsoas musculature, extending into the left hip and into the left side of L3, L4, L5 vertebral bodies and through L4 transverse process measuring up to 24.6 x 11.5 x 13 cm. Pathology revealed spindle cell sarcoma composed of moderately atypical, elongated spindle cells positive for vimentin, with loss of H3/K27me3, and negative for SMA, S-100 consistent with MPNSTs. Conclusions: The is a rare case of a sporadic presentation of MPNTs. Treatment depends on the extent of tumor burden and metastatic disease is typically treated with chemotherapy. CT chest showed innumerable pulmonary nodules. Patient is currently being treated with Doxorubicin and Ifosfamide with minimal response

Maize Provisioning of Ontario Late Woodland Turkeys: Isotopic Evidence of Seasonal, Cultural, Spatial and Temporal Variation

The isotopic composition (δ13C, δ15N) of bone collagen from Ontario Late Woodland archaeological turkeys was compared with that of modern Ontario wild turkeys, and archaeological turkeys from American Southwestern, Mexican and other Woodland sites to determine whether Late Woodland Ontario peoples managed wild turkeys by provisioning them with maize, the only isotopically distinct horticultural plant at that time. Despite the fact that humans from Late Woodland Western Basin and Iroquoian traditions consumed equal amounts of maize, wild turkeys utilized by the two groups exhibit different diets. Western Basin turkeys reflect a C3-only diet, whereas Iroquoian turkeys were consuming significant quantities of maize (a C4 plant). Both groups of archaeological turkey consumed less maize than modern wild turkeys with access to waste left in fields by mechanized agriculture, but because ancient crop yields were much lower, we suggest that Iroquoian turkeys must have been provisioned, probably to create a reliable and nearby hunting niche (Linares 1976). Archaeological and isotopic evidence supports ethnohistoric accounts that turkeys were hunted after the fall harvest. Iroquoian archaeological turkey diets, in general, reflect the seasonal consumption of maize that would have been created by cold weather maize provisioning, with the major exception of one turkey from an Attawandaron (Neutral) site that appears to have been fed maize year round. Motivations for provisioning by Middle Ontario Iroquoian people likely included climate change and ritual/ceremonial activity as well as a reliable food supply. Because Iroquoian women controlled the harvest, it is likely that they were instrumental in altering this human/animal interaction, creating a position on the wild/domesticated continuum that is unique in the North American archaeological literature

The Physical Conditions and Dynamics of the Interstellar Medium in the Nucleus of M83: Observations of CO and CI

This paper presents CI, CO J=4-3, and CO J=3-2 maps of the barred spiral galaxy M83 taken at the James Clerk Maxwell Telescope. Observations indicate a double peaked structure which is consistent with gas inflow along the bar collecting at the inner Lindblad resonance. This structure suggests that nuclear starbursts can occur even in galaxies where this inflow/collection occurs, in contrast to previous studies of barred spiral galaxies. However, the observations also suggest that the double peaked emission may be the result of a rotating molecular ring oriented nearly perpendicular to the main disk of the galaxy. The CO J=4-3 data indicate the presence of warm gas in the nucleus that is not apparent in the lower-J CO observations, which suggests that CO J=1-0 emission may not be a reliable tracer of molecular gas in starburst galaxies. The twelve CI/CO J=4-3 line ratios in the inner 24'' x 24'' are uniform at the 2 sigma level, which indicates that the CO J=4-3 emission is originating in the same hot photon-dominated regions as the CI emission. The CO J=4-3/J=3-2 line ratios vary significantly within the nucleus with the higher line ratios occurring away from peaks of emission along an arc of active star forming regions. These high line ratios (>1) likely indicate optically thin gas created by the high temperatures caused by star forming regions in the nucleus of this starburst galaxy.Comment: 15 pages with 10 figures. To appear in the August 10 1998 issue of The Astrophysical Journa

ROSAT PSPC Observations of the Richest (R≥2R \geq 2) ACO Clusters

We have compiled an X-ray catalog of optically selected rich clusters of galaxies observed by the PSPC during the pointed GO phase of the ROSAT mission. This paper contains a systematic X-ray analysis of 150 clusters with an optical richness classification of $R \geq 2$ from the ACO catalog (Abell, Corwin, and Olowin 1989). All clusters were observed within 45' of the optical axis of the telescope during pointed PSPC observations. For each cluster, we calculate: the net 0.5-2.0 keV PSPC count rate (or $4 \sigma$ upper limit) in a 1 Mpc radius aperture, 0.5-2.0 keV flux and luminosity, bolometric luminosity, and X-ray centroid. The cluster sample is then used to examine correlations between the X-ray and optical properties of clusters, derive the X-ray luminosity function of clusters with different optical classifications, and obtain a quantitative estimate of contamination (i.e, the fraction of clusters with an optical richness significantly overestimated due to interloping galaxies) in the ACO catalog

Limiting the impact of destructive analytical techniques through sequential microspatial sampling of the enamel from single teeth

A fundamental research concern within contemporary bioarchaeology is the sensitive balance between the preservation of human remains and the use of destructive techniques to collect information. Here we describe one example of how multiple microspatial destructive/semi-destructive techniques may be carried out in sequence using only the enamel of a single tooth. With careful planning of both sample preparation strategies and sequencing of sampling methods, it is possible to produce multiple datasets, and yet to retain material for future analyses. In this case, enamel from the teeth of 27 individuals who lived during the early medieval period (AD 1170-1198) in Bergen, Norway, were subjected to histological, trace element (LA-ICP-MS), diagenetic (FTIR), and isotopic analyses (δ18O and δ13C, via micromill/multiprep/IRMS)

Inequality in access to hearing care for older adults in residential homes

White, Joanna D. - ORCID 0000-0002-6513-8225 https://orcid.org/0000-0002-6513-8225Johnson, Christine - ORCID 0000-0001-8573-5396 https://orcid.org/0000-0001-8573-5396Background The population of older people in residential homes is projected to rise. There are unrecognized hearing difficulties among residents and prevalence of hearing loss in this population is underreported. This can result in an overestimation of levels of cognitive impairment. Untreated hearing loss is associated with social isolation, depression, disruptive behaviour and cognitive decline. This study aimed to explore the provision of hearing care (hearing assessment, rehabilitation and staff training) in Scottish care homes for older people.Methods A survey comprising 18 questions was distributed to the managers (or designated staff members) of 659 care homes across Scotland.Results Responses were obtained from 154 care homes. The results support existing evidence that hearing is not assessed in the majority of homes, resulting in under detection of hearing loss. Staff lack training in supporting residents’ hearing needs. Access to hearing care in residential homes differs across health board areas.Conclusions There is an urgent requirement for hearing assessment of older adults on admission to residential care. Care providers require this information to construct effective care plans and mitigate the effects of hearing loss. Those responsible for providing hearing rehabilitation services require information about service users to address any unmet need.https://doi.org/10.1093/pubmed/fdz08543pubpub

Therapeutic administration of Tregitope-Human Albumin Fusion with Insulin Peptides to promote Antigen-Specific Adaptive Tolerance Induction.

Type 1 Diabetes (T1D) is an autoimmune disease that is associated with effector T cell (Teff) destruction of insulin-producing pancreatic beta-islet cells. Among the therapies being evaluated for T1D is the restoration of regulatory T cell (Treg) activity, specifically directed toward down-modulation of beta-islet antigen-specific T effector cells. This is also known as antigen-specific adaptive tolerance induction for T1D (T1D ASATI). Tregitopes (T regulatory cell epitopes) are natural T cell epitopes derived from immunoglobulin G (IgG) that were identified in 2008 and have been evaluated in several autoimmune disease models. In the T1D ASATI studies presented here, Tregitope peptides were administered to non-obese diabetic (NOD) mice at the onset of diabetes within two clinically-relevant delivery systems (liposomes and in human serum albumin [HSA]-fusion products) in combination with preproinsulin (PPI) target antigen peptides. The combination of Tregitope-albumin fusions and PPI peptides reduced the incidence of severe diabetes and reversed mild diabetes, over 49 days of treatment and observation. Combining HSA-Tregitope fusions with PPI peptides is a promising ASATI approach for therapy of T1D

Gravitational Mesoscopic Constraints in Cosmological Dark Matter Halos

We present an analysis of the behaviour of the `coarse-grained' (`mesoscopic') rank partitioning of the mean energy of collections of particles composing virialized dark matter halos in a Lambda-CDM cosmological simulation. We find evidence that rank preservation depends on halo mass, in the sense that more massive halos show more rank preservation than less massive ones. We find that the most massive halos obey Arnold's theorem (on the ordering of the characteristic frequencies of the system) more frequently than less massive halos. This method may be useful to evaluate the coarse-graining level (minimum number of particles per energy cell) necessary to reasonably measure signatures of `mesoscopic' rank orderings in a gravitational system.Comment: LaTeX, 15 pages, 3 figures. Accepted for publication in Celestial Mechanics and Dynamical Astronomy Journa

The effects of dynamical substructure on Milky Way mass estimates from the high velocity tail of the local stellar halo

We investigate the impact of dynamical streams and substructure on estimates of the local escape speed and total mass of Milky Way-mass galaxies from modelling the high velocity tail of local halo stars. We use a suite of high-resolution, magneto-hydrodynamical cosmological zoom-in simulations, which resolve phase space substructure in local volumes around solar-like positions. We show that phase space structure varies significantly between positions in individual galaxies and across the suite. Substructure populates the high velocity tail unevenly and leads to discrepancies in the mass estimates. We show that a combination of streams, sample noise and truncation of the high velocity tail below the escape speed leads to a distribution of mass estimates with a median that falls below the true value by $\sim 20 \%$, and a spread of a factor of 2 across the suite. Correcting for these biases, we derive a revised value for the Milky Way mass presented in Deason et al. of $1.29 ^{+0.37}_{-0.47} \times 10^{12}$ $\rm M_{\odot}$.Comment: Re-submitted to MNRAS Letters after minor revisio

Police, public, and offender perceptions of body-worn video: a single jurisdictional multiple-perspective analysis

Objectives. Police, public, and offender survey responses from a single jurisdiction give a multiple-perspective insight into the use of body-worn video (BWV) cameras by police. Methods. Police attitudinal data was collected from before (n = 190), during (n = 139), and at the conclusion (n = 221) of a BWV implementation trial. Public attitudes were collected at the conclusion of the BWV implementation trial via online survey (n = 995 respondents) and intercept survey (n = 428 respondents). Offender attitudes (n = 302) were collected in police custody over a 6-month period immediately preceding the BWV trial. Results. The extent to which police felt BWV influenced their behavior tempered during the trial. All three perspectives were supportive of the use of BWV. The public who had encountered BWV-wearing officers and the offender sample indicated limited belief that BWV would reduce bad behavior. There was also clear contention about the policy and practice decisions around recording. Conclusions. These findings have significance for BWV trials, commenting on the importance of (a) collecting police attitudes at multiple points, (b) separating the attitudes of public who did encounter police wearing BWV, and (c) data collection and policy for evaluation outcomes