Desarrollo de un aderezo saludable a base de aceite de canola: influencia de la viscosidad en la percepción del sabor y preferencias de los consumidores

El aceite de canola (fuente de vitamina E)contiene grasos esenciales, omega 3 y omega 6.El objetivo de este trabajo fue desarrollar un aderezo con bajo contenido graso, saludable y sabroso. Para la mezcla base se probaron dos gomas –guar y xántica- con el agregado de inulina como fibra saludable, aceite de canola, mostaza en polvo y betacaroteno como colorante. La saborización se realizó ensayando siete condimentos y sus combinaciones. Las muestras fueron caracterizadas por su comportamiento reológico y la preferencia de los consumidores.Fil: Whelan, María Rosario. Universidad Tecnológica Nacional. Facultad Regional Buenos Aires; ArgentinaFil: Cairo, Federico. Universidad Tecnológica Nacional. Facultad Regional Buenos Aires; ArgentinaFil: Zangrando, Agustina. Universidad Tecnológica Nacional. Facultad Regional Buenos Aires; ArgentinaFil: Hovsepian, Julieta. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Agrarias; ArgentinaFil: Santana, Susana Noemi. Universidad Tecnológica Nacional. Facultad Regional Buenos Aires; ArgentinaFil: Zamora, María Clara. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; ArgentinaFil: de Breier, Rosa M.. Universidad Tecnológica Nacional. Facultad Regional Buenos Aires; Argentin

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele