2,006 research outputs found
Finite-time quantum-to-classical transition for a Schroedinger-cat state
The transition from quantum to classical, in the case of a quantum harmonic
oscillator, is typically identified with the transition from a quantum
superposition of macroscopically distinguishable states, such as the
Schr\"odinger cat state, into the corresponding statistical mixture. This
transition is commonly characterized by the asymptotic loss of the interference
term in the Wigner representation of the cat state. In this paper we show that
the quantum to classical transition has different dynamical features depending
on the measure for nonclassicality used. Measures based on an operatorial
definition have well defined physical meaning and allow a deeper understanding
of the quantum to classical transition. Our analysis shows that, for most
nonclassicality measures, the Schr\"odinger cat dies after a finite time.
Moreover, our results challenge the prevailing idea that more macroscopic
states are more susceptible to decoherence in the sense that the transition
from quantum to classical occurs faster. Since nonclassicality is prerequisite
for entanglement generation our results also bridge the gap between
decoherence, which appears to be only asymptotic, and entanglement, which may
show a sudden death. In fact, whereas the loss of coherences still remains
asymptotic, we have shown that the transition from quantum to classical can
indeed occur at a finite time.Comment: 9+epsilon pages, 4 figures, published version. Originally submitted
as "Sudden death of the Schroedinger cat", a bit too cool for APS policy :-
In search of clarity about parity
First paragraph: Andy Clark's Supersizing the Mind: Embodiment, Action, and Cognitive Extension (Clark 2008) is, among other things, a characteristically bold and timely defence of the extended mind hypothesis (Clark and Chalmers 1998). According to this hypothesis, which Clark here calls EXTENDED, the physical mechanisms of mind (the material vehicles that realize cognition) sometimes extend beyond the traditional boundaries of skull and skin, such that "actions and loops through nonbiological structure [sometimes count] as genuine aspects of extended cognitive processes" (p. 85). In the brief treatment that follows I cannot hope to engage with everything that is worthy of discussion in Clark's rich and exciting text, so I shall content myself with exploring and assessing a central thread in his argument for EXTENDED. That thread revolves around what is called the parity principle. Here is how that principle is formulated in Supersizing the Mind (p. 77, drawing on Clark and Chalmers 1998, p. 8): If, as we confront some task, a part of the world functions as a process which, were it to go on in the head, we would have no hesitation in accepting as part of the cognitive process, then that part of the world is (for that time) part of the cognitive process. The general idea is this: if there is functional equality with respect to governing intelligent behaviour (for example, in the way stored information is poised to guide such behaviour), between the causal contribution of certain internal elements and the causal contribution of certain external elements, and if the internal elements concerned already qualify as the proper parts of a cognitive trait (system, state, process, mechanism, architecture...), then there is no good reason to deny equivalent status to the relevant external elements. Parity of causal contribution mandates parity of status with respect to the cognitive
Genetic contribution to radiographic severity in osteoarthritis of the knee
Objective Knee osteoarthritis (OA) has a significant genetic component. The authors have assessed the role of three variants reported to influence risk of knee OA with p<5×10–8 in determining patellofemoral and tibiofemoral Kellgren Lawrence (K/L) grade in knee OA cases.
Methods 3474 knee OA cases with sky-line and weight-bearing antero-posterior x-rays of the knee were selected based on the presentation of K/L grade ≥2 at either the tibiofemoral or patellofemoral compartments for one or both knees. Patients belonging to three UK cohorts, were genotyped for rs143383, rs4730250 and rs11842874 mapping to the GDF5, COG5 and MCF2L genes, respectively. The association between tibiofemoral K/L grade and patellofemoral K/L grade was assessed after adjusting for age, gender and body mass index.
Results No significant association was found between the rs4730250 and radiographic severity. The rs11842874 mapping to MCF2L was found to be nominally significantly associated with patellofemoral K/L grade as a quantitative trait (p=0.027) but not as a binary trait. The GDF5 single nucleotide polymorphism rs143383 was associated with tibiofemoral K/L grade (β=0.05 (95% CI 0.02 to 0.08) p=0.0011).
Conclusions Our data indicate that within individuals affected by radiographic knee OA, OAGDF5 has a modest but significant effect on radiographic severity after adjustment for the major risk factors
Normalization and centering of array-based heterologous genome hybridization based on divergent control probes
<p>Abstract</p> <p>Background</p> <p>Hybridization of heterologous (non-specific) nucleic acids onto arrays designed for model-organisms has been proposed as a viable genomic resource for estimating sequence variation and gene expression in non-model organisms. However, conventional methods of normalization that assume equivalent distributions (such as quantile normalization) are inappropriate when applied to non-specific (heterologous) hybridization. We propose an algorithm for normalizing and centering intensity data from heterologous hybridization that makes no prior assumptions of distribution, reduces the false appearance of homology, and provides a way for researchers to confirm whether heterologous hybridization is suitable.</p> <p>Results</p> <p>Data are normalized by adjusting for Gibbs free energy binding, and centered by adjusting for the median of a common set of control probes assumed to be equivalently dissimilar for all species. This procedure was compared to existing approaches and found to be as successful as Loess normalization at detecting sequence variations (deletions) and even more successful than quantile normalization at reducing the accumulation of false positive probe matches between two related nematode species, <it>Caenorhabditis elegans </it>and <it>C. briggsae</it>. Despite the improvements, we still found that probe fluorescence intensity was too poorly correlated with sequence similarity to result in reliable detection of matching probe sequence.</p> <p>Conclusions</p> <p>Cross-species hybridizations can be a way to adapt genome-enabled tools for closely related non-model organisms, but data must be appropriately normalized and centered in a way that accommodates hybridization of nucleic acids with diverged sequence. For short, 25-mer probes, hybridization intensity alone may be insufficiently correlated with sequence similarity to allow reliable inference of homology at the probe level.</p
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Production and partitioning of organic matter during simulated phytoplankton blooms
Few studies have examined the partitioning of organic matter in upwelling systems, despite the fact that these systems play a key role in carbon and nitrogen budgets in the ocean. We examined the production and partitioning of phytoplankton-derived organic matter in deck incubations off Oregon during the upwelling season. During exponential growth of the phytoplankton, ≥78% of total accumulated organic matter was in particulate (POM) form. This suggests that dissolved organic matter (DOM) is a small fraction of primary production during the exponential growth of coastal phytoplankton blooms. After nitrate depletion, carbon-rich (C:N ≥ 16) DOM accumulated in incubations dominated by the diatom Chaetoceros sp., accounting for 38% (±8.5%) of accumulated total organic carbon (TOC) and 24% (±8%) of accumulated total organic nitrogen (TON). However, in a bloom dominated by the diatom Leptocylindrus minimus, a relatively smaller amount of DOM accumulated, accounting for only 15% of accumulated TOC and 7% of accumulated TON. On the basis of measured concentrations of nitrate and accumulated TOC, ~70%–157% more carbon was fixed than would be predicted by Redfield stoichiometry (referred to as "excess carbon fixation"), with 20%–69% of the excess carbon fixation occurring after nitrate depletion. The accumulation of carbon-rich DOM and excess carbon fixation suggests that nitrate assimilation (i.e., new production) might not equate to net production of POM in coastal upwelling systems
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Release of dissolved organic matter by coastal diatoms
Dissolved organic matter (DOM) production was examined in axenic batch cultures of five coastal diatom species. For Chaetoceros decipiens, dissolved organic carbon (DOC) accumulated beginning in late exponential growth as a result of increased cell density. For Cylindrotheca closterium, DOC actually decreased in late exponential growth and reached zero by the end of the experiment. This coincided with continued particulate organic carbon (POC) production and a threefold increase in the per‐cell concentration of transparent exopolymer particles after nutrients were depleted. DOC release rates varied between species but were significantly higher for all five species in exponential or transition growth than during stationary growth. On average, 5% of the total fixed C was released as DOC for four of the diatoms, whereas C. decipiens released ~21% of its fixed C as DOC. The percentage of fixed C released as DOC varied little with nutrient availability or diatom growth stage. The DOM produced by some diatom species adheres to filters and is measured in the particulate organic matter (POM) fraction when cells are separated from the medium by filtration. This may be an important problem when diatom species with known benthic life histories are prevalent. In contrast, for species like Chaetoceros that have no benthic life history, DOM release rates estimated by bulk measurements or ¹⁴C appear to be accurate. Overall, these results indicate that the species composition of phytoplankton blooms has the potential to influence the relative importance of POM and DOM production and can complicate interpretation of those measurements.Keywords: Coastal diatoms, Dissolved organic matte
The genetic contribution to severe post-traumatic osteoarthritis
Objective: to compare the combined role of genetic variants loci associated with risk of knee or hip osteoarthritis (OA) in post-traumatic (PT) and non-traumatic (NT) cases of clinically severe OA leading to total joint replacement.
Methods: A total of 1590 controls, 2168 total knee replacement (TKR) cases (33.2% PT) and 1567 total hip replacement (THR) cases (8.7% PT) from 2 UK cohorts were genotyped for 12 variants previously reported to be reproducibly associated with risk of knee or hip OA. A genetic risk score was generated and the association with PT and NT TKR and THR was assessed adjusting for covariates.
Results: For THR, each additional genetic risk variant conferred lower risk among PT cases (OR=1.07, 95% CI 0.96 to 1.19; p=0.24) than NT cases (OR 1.11, 95% CI 1.06 to 1.17; p=1.55×10−5). In contrast, for TKR, each risk variant conferred slightly higher risk among PT cases (OR 1.12, 95% CI 1.07 to 1.19; p=1.82×10−5) than among NT cases (OR 1.08, 95% CI 1.03 to 1.1; p=0.00063).
Conclusions: Based on the variants reported to date PT TKR cases have at least as high a genetic contribution as NT cases
Plants Survive Rapid Decompression: Implications for Bioregenerative Life Support
No abstract availabl
The effect of FTO variation on increased osteoarthritis risk is mediated through body mass index : a mendelian randomisation study
Objective:
Variation in the fat mass and obesity-associated (FTO) gene influences susceptibility to obesity. A variant in the FTO gene has been implicated in genetic risk to osteoarthritis (OA). We examined the role of the FTO polymorphism rs8044769 in risk of knee and hip OA in cases and controls incorporating body mass index (BMI) information.
Methods:
5409 knee OA patients, 4355 hip OA patients and up to 5362 healthy controls from 7 independent cohorts from the UK and Australia were genotyped for rs8044769. The association of the FTO variant with OA was investigated in case/control analyses with and without BMI adjustment and in analyses matched for BMI category. A mendelian randomisation approach was employed using the FTO variant as the instrumental variable to evaluate the role of overweight on OA.
Results:
In the meta-analysis of all overweight (BMI≥25) samples versus normal-weight controls irrespective of OA status the association of rs8044769 with overweight is highly significant (OR[CIs] for allele G=1.14 [01.08 to 1.19], p=7.5×10−7). A significant association with knee OA is present in the analysis without BMI adjustment (OR[CIs]=1.08[1.02 to 1.14], p=0.009) but the signal fully attenuates after BMI adjustment (OR[CIs]=0.99[0.93 to 1.05], p=0.666). We observe no evidence for association in the BMI-matched meta-analyses. Using mendelian randomisation approaches we confirm the causal role of overweight on OA.
Conclusions:
Our data highlight the contribution of genetic risk to overweight in defining risk to OA but the association is exclusively mediated by the effect on BMI. This is consistent with what is known of the biology of the FTO gene and supports the causative role of high BMI in OA
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