2014 Audio Contest runner-up in prose : Ugly pew

PodcastThis week on The Missouri Review Podcast we are pleased to feature Joshua Wheeler's radio essay "Ugly pew," which was the runner-up in the prose category of the 2014 Audio Contest

Enantiocontrolled solid-state photodimerizations via a chiral sulfonamidecinnamic acid

The supramolecular patterns of three polymorphs of a chiral sulfonamidecinnamic acid reveal components effectively organized into predetermined hydrogen-bonded dimers with favorable \u3c3.8A ° olefin spacing for enantioselective single-crystal-to-single-crystal [2 + 2] photodimerization reactions

A Comparative Study of Three Feedback Devices for Residential Real-Time Energy Monitoring

Residential energy consumption accounts for 21% of the total electricity use in the United States. Unfortunately, research indicates that almost 41% of this power is wasted. Changing the way that consumers use energy may be important in reducing home energy consumption. This paper looks at whether the implementation of certain real-time energy monitors has an impact on the residential rate of energy consumption in a metropolitan area with relatively low electricity rates. In the following case study, 151 Omaha residences were equipped with two variants of the Aztech In-Home Display (Aztech) as well as the Blue Line Power Cost Monitor (PCM) real-time energy monitors for a period of 16 months. The results of the data, 30 days after installation, revealed a statistically insignificant reduction of 12% in mean electrical consumption in houses equipped with a PCM and no reduction in mean consumption in homes using either variants of the Aztech device when compared to a randomly selected control sample. However, they proved effective in the short term if utilized by utilities for mass distribution to foster awareness among participating residents of their own patterns of residential electricity consumption and on the environmental impacts of energy saving

Behavioral and Electrophysiological Indices of Negative Affect Predict Cocaine Self-Administration

The motivation to seek cocaine comes in part from a dysregulation of reward processing manifested in dysphoria, or affective withdrawal. Learning is a critical aspect of drug abuse; however, it remains unclear whether drug-associated cues can elicit the emotional withdrawal symptoms that promote cocaine use. Here we report that a cocaine-associated taste cue elicited a conditioned aversive state that was behaviorally and neurophysiologically quantifiable and predicted subsequent cocaine self-administration behavior. Specifically, brief intraoral infusions of a cocaine-predictive flavored saccharin solution elicited aversive orofacial responses that predicted early-session cocaine taking in rats. The expression of aversive taste reactivity also was associated with a shift in the predominant pattern of electrophysiological activity of nucleus accumbens (NAc) neurons from inhibitory to excitatory. The dynamic nature of this conditioned switch in affect and the neural code reveals a mechanism by which cues may exert control over drug self-administration

A Comparative Study of Three Feedback Devices for Residential Real-Time Energy Monitoring

Residential energy consumption accounts for 21% of the total electricity use in the United States. Unfortunately, research indicates that almost 41% of this power is wasted. Changing the way that consumers use energy may be important in reducing home energy consumption. This paper looks at whether the implementation of certain real-time energy monitors has an impact on the residential rate of energy consumption in a metropolitan area with relatively low electricity rates. In the following case study, 151 Omaha residences were equipped with two variants of the Aztech In-Home Display (Aztech) as well as the Blue Line Power Cost Monitor (PCM) real-time energy monitors for a period of 16 months. The results of the data, 30 days after installation, revealed a statistically insignificant reduction of 12% in mean electrical consumption in houses equipped with a PCM and no reduction in mean consumption in homes using either variants of the Aztech device when compared to a randomly selected control sample. However, they proved effective in the short term if utilized by utilities for mass distribution to foster awareness among participating residents of their own patterns of residential electricity consumption and on the environmental impacts of energy saving

Basolateral Amygdala Modulates Terminal Dopamine Release in the Nucleus Accumbens and Conditioned Responding

Background—Dopamine signaling in the nucleus accumbens (NAc) is essential for goal-directed behaviors and primarily arises from burst firing of ventral tegmental area (VTA) neurons. However, the role of associative neural substrates such as the basolateral amygdala (BLA) in regulating phasic dopamine release in the NAc, particularly during reward-seeking, remains unknown. Methods—Male Sprague-Dawley rats learned to discriminate two cues; a discriminative stimulus (DS) that predicted sucrose reinforcement contingent upon a lever press, and a non-associated stimulus (NS) that predicted a second lever never reinforced with sucrose. Following training, a test session was completed in which NAc dopamine was measured using fast-scan cyclic voltammetry in conjunction with inactivation of the ipsilateral BLA (GABA agonists; baclofen/muscimol) to determine the contribution of BLA activity to dopamine release in the NAc core during the task. Results—Under vehicle conditions, DS and NS presentation elicited dopamine release within the NAc core. The DS evoked significantly more dopamine than the NS. Inactivation of the BLA selectively attenuated the magnitude of DS-evoked dopamine release, concurrent with an attenuation of DS-evoked conditioned approaches. Other behavioral responses (e.g., lever pressing) and dopamine release concomitant with those events were unaltered by BLA inactivation. Furthermore, neither VTA electrically-stimulated dopamine release nor the probability of high concentration dopamine release events was altered following BLA inactivation. Conclusions—These results demonstrate that the BLA terminally modulates dopamine signals within the NAc core under specific, behaviorally-relevant conditions, illustrating a functional mechanism by which the BLA selectively facilitates responding to motivationally salient environmental stimuli

The Inflammatory Bowel Diseases and Ambient Air Pollution: A Novel Association

OBJECTIVES: The inflammatory bowel diseases (IBDs) emerged after industrialization. We studied whether ambient air pollution levels were associated with the incidence of IBD. METHODS: The health improvement network (THIN) database in the United Kingdom was used to identify incident cases of Crohn's disease (n=367) or ulcerative colitis (n=591), and age- and sex-matched controls. Conditional logistic regression analyses assessed whether IBD patients were more likely to live in areas of higher ambient concentrations of nitrogen dioxide (NO(2)), sulfur dioxide (SO(2)), and particulate matter <10 μm (PM(10)), as determined by using quintiles of concentrations, after adjusting for smoking, socioeconomic status, non-steroidal anti-inflammatory drugs (NSAIDs), and appendectomy. Stratified analyses investigated effects by age. RESULTS: Overall, NO(2), SO(2), and PM(10) were not associated with the risk of IBD. However, individuals ≤23 years were more likely to be diagnosed with Crohn's disease if they lived in regions with NO(2) concentrations within the upper three quintiles (odds ratio (OR)=2.31; 95% confidence interval (CI)=1.25-4.28), after adjusting for confounders. Among these Crohn's disease patients, the adjusted OR increased linearly across quintile levels for NO(2) (P=0.02). Crohn's disease patients aged 44-57 years were less likely to live in regions of higher NO(2) (OR=0.56; 95% CI=0.33-0.95) and PM(10) (OR=0.48; 95% CI=0.29-0.80). Ulcerative colitis patients ≤25 years (OR=2.00; 95% CI=1.08-3.72) were more likely to live in regions of higher SO(2); however, a dose-response effect was not observed. CONCLUSIONS: On the whole, air pollution exposure was not associated with the incidence of IBD. However, residential exposures to SO(2) and NO(2) may increase the risk of early-onset ulcerative colitis and Crohn's disease, respectively. Future studies are needed to explore the age-specific effects of air pollution exposure on IBD risk