21 research outputs found

    Guidelines of the American Society of Mammalogists for the use of wild mammals in research

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    Guidelines for use of wild mammal species are updated from the American Society of Mammalogists (ASM) 2007 publication. These revised guidelines cover current professional techniques and regulations involving mammals used in research and teaching. They incorporate additional resources, summaries of procedures, and reporting requirements not contained in earlier publications. Included are details on marking, housing, trapping, and collecting mammals. It is recommended that institutional animal care and use committees (IACUCs), regulatory agencies, and investigators use these guidelines as a resource for protocols involving wild mammals. These guidelines were prepared and approved by the ASM, working with experienced professional veterinarians and IACUCs, whose collective expertise provides a broad and comprehensive understanding of the biology of nondomesticated mammals in their natural environments. The most current version of these guidelines and any subsequent modifications are available at the ASM Animal Care and Use Committee page of the ASM Web site (http://mammalsociety.org/committees/index.asp).American Society of Mammalogist

    The Ursinus Weekly, February 21, 1974

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    Theatre production will start week of arts festivities • Service stations in Collegeville reflect national trends in current fuel shortage • Whitians name nineteen new members to group • Freshman class discusses donations, cut system • Open house policy to continue this semester • Strategy is key word in new club • Editorials: Solzhenitsyn: One man in the world; Behind the green porn • Letter to the editor: Faculty flops • Forum Review: Dr. Joseph Feldmeier • Alumni Corner: Dr. Jacob Shade • In concert: Yes, even closer to the edge • The Zodiac: Will Ursinus survive the Aquarian age? • Little known Bill of Rights, responsibilities makes its appearance after three years • What can you say? • Grapplers close season; boast 3 shut-outs in rowhttps://digitalcommons.ursinus.edu/weekly/1010/thumbnail.jp

    γ-Tocotrienol Induces Growth Arrest Through a Novel Pathway With TGFβ2 in Prostate Cancer

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    Regions along the Mediterranean and in southern Asia have lower prostate cancer incidence compared to the rest of the world. It has been hypothesized that one of the potential contributing factors for this low incidence includes a higher intake of tocotrienols. Here we examine the potential of γ-tocotrienol (GT3) to reduce prostate cancer proliferation and focus on elucidating pathways by which GT3 could exert a growth-inhibitory effect on prostate cancer cells. We find that the γ and δ isoforms of tocotrienol are more effective at inhibiting the growth of prostate cancer cell lines (PC-3 and LNCaP) compared with the γ and δ forms of tocopherol. Knockout of PPAR-γ and GT3 treatment show inhibition of prostate cancer cell growth, through a partially PPAR-γ-dependent mechanism. GT3 treatment increases the levels of the 15-lipoxygenase-2 enzyme, which is responsible for the conversion of arachidonic acid to the PPAR-γ-activating ligand 15-S-hydroxyeicosatrienoic acid. In addition, the latent precursor and the mature forms of TGFβ2 are down-regulated after treatment with GT3, with concomitant disruptions in TGFβ receptor I, SMAD-2, p38, and NF-κB signaling
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