OVERVIEW OF THE EXPERIMENTAL DETERMINATION OF ACOUSTIC FLOW ON THE BASIS OF SOUND INTENSITY MEASUREMENTS

A large variety of CFD/CAA hybrid approaches are commonly used today for aero-acoustic engineering applications using equations and the coupling between source and acoustic propagation region. The coupling is usually made using Lighthill’s acoustic analogies and Kirhchoff’s acoustic boundary conditions. This paper intends to give answer how the size and shape of the source may be influence on the accuracy of the different coupling methods and their sensitivity. In this way, some experimental investigation was made using sound intensity measurement technique to the graphic presentation of the spatial distribution of the acoustic power flow over various geometrical shapes of structures located in a three-dimensional space. The results of these studies contribute to the theory of sound and general knowledge about the physics of flow acoustic phenomena, especially in the near acoustic field. As a result of research, the visualization analysis of the sound intensity flux in 3D space is shown as flow wave reactions on the presence of obstacles with different shapes. The results of vectors flow fields around a rectangular and circular plate, over the cavity and inside a ducts are show. The visualization of acoustic power flow in real-life acoustic fields can explain many particular energetic acoustic effects like scattering, vortex flow in shielding area, etc., concerning areas where it is difficult to make numerical analysis

4,4′-Bipyridine–trans,trans-hexa-2,4-dienedioic acid (1/1)

The title cocrystal, C10H8N2·C6H6O4, crystallizes with half-mol­ecules of 4,4′-bipyridine and trans,trans-hexa-2,4-dienedioic acid in the asymmetric unit, as each is located about a crystallographic inversion center. The bipyridine molecule is planar from symmetry. In the dicarboxylic acid molecule, the O—C—C—C torsion angle is −13.0 (2)°. In the crystal, O—H⋯N and C—H⋯O hydrogen bonds generate a three-dimensional network

3-Amino­benzonitrile–3,5-dinitro­benzoic acid (1/1)

The asymmetric unit of the title co-crystal, C7H6N2·C7H4N2O6, contains two formula units of both components. The crystal structure is stabilized by inter­molecular O—H⋯O, N—H⋯O, N—H⋯N and C—H⋯O hydrogen bonds, generating a two-dimensional wave-like network. π–π stacking inter­actions [centroid–centroid distances = 3.702 (2), 3.660 (2)and 3.671 (2) Å] stabilize the crystal packing

Mitochondrial genomics reveals the evolutionary history of the porpoises (Phocoenidae) across the speciation continuum

Historical variation in food resources is expected to be a major driver of cetacean evolution, especially for the smallest species like porpoises. Despite major conservation issues among porpoise species (e.g., vaquita and finless), their evolutionary history remains understudied. Here, we reconstructed their evolutionary history across the speciation continuum. Phylogenetic analyses of 63 mitochondrial genomes suggest that porpoises radiated during the deep environmental changes of the Pliocene. However, all intra-specific subdivisions were shaped during the Quaternary glaciations. We observed analogous evolutionary patterns in both hemispheres associated with convergent evolution to coastal versus oceanic environments. This suggests that similar mechanisms are driving species diversification in northern (harbor and Dall's) and southern species (spectacled and Burmeister's). In contrast to previous studies, spectacled and Burmeister's porpoises shared a more recent common ancestor than with the vaquita that diverged from southern species during the Pliocene. The low genetic diversity observed in the vaquita carried signatures of a very low population size since the last 5,000 years. Cryptic lineages within Dall's, spectacled and Pacific harbor porpoises suggest a richer evolutionary history than previously suspected. These results provide a new perspective on the mechanisms driving diversification in porpoises and an evolutionary framework for their conservation

Oral Fluid–Based Biomarkers of Alveolar Bone Loss in Periodontitis

Periodontal disease is a bacteria-induced chronic inflammatory disease affecting the soft and hard supporting structures encompassing the teeth. When left untreated, the ultimate outcome is alveolar bone loss and exfoliation of the involved teeth. Traditional periodontal diagnostic methods include assessment of clinical parameters and radiographs. Though efficient, these conventional techniques are inherently limited in that only a historical perspective, not current appraisal, of disease status can be determined. Advances in the use of oral fluids as possible biological samples for objective measures of current disease state, treatment monitoring, and prognostic indicators have boosted saliva and other oral-based fluids to the forefront of technology. Oral fluids contain locally and systemically derived mediators of periodontal disease, including microbial, host-response, and bone-specific resorptive markers. Although most biomarkers in oral fluids represent inflammatory mediators, several specific collagen degradation and bone turnover-related molecules have emerged as possible measures of periodontal disease activity. Pyridinoline cross-linked carboxyterminal telopeptide (ICTP), for example, has been highly correlated with clinical features of the disease and decreases in response to intervention therapies, and has been shown to possess predictive properties for possible future disease activity. One foreseeable benefit of an oral fluid–based periodontal diagnostic would be identification of highly susceptible individuals prior to overt disease. Timely detection and diagnosis of disease may significantly affect the clinical management of periodontal patients by offering earlier, less invasive, and more cost-effective treatment therapies.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73247/1/annals.1384.028.pd

Identification of a new cocrystal of citric acid and paracetamol of pharmaceutical relevance

Cocrystals have been increasingly recognized as an attractive alternative delivery form for solid drug products. In this work, Raman spectroscopy, X-ray powder diffraction/X-ray crystallography, and differential scanning calorimetry have been used to study the phenomenon of cocrystal formation in stoichiometric mixtures of citric acid with paracetamol. Raman spectroscopy was particularly useful for the characterization of the products and was used to determine the nature of the interactions in the cocrystals. It was observed that little change in the vibrational modes associated with the phenyl groups of the respective reactants took place upon cocrystal formation but changes in intensities of the vibrational modes associated with the amide and the carboxylic acid groups were observed upon cocrystal formation. Several new vibrational bands were identified in the cocrystal which were not manifest in the raw material and could be used as diagnostic features of cocrystal formation. An understanding of the effects of cocrystal formation on the vibrational modes was obtained by the complete assignment of the spectra of the starting materials and of the cocrystal component. The results show that the cocrystals was obtained in a 2:1 molar ratio of paracetamol to citric acid. The asymmetric unit of the crystal contains two paracetamol molecules hydrogen-bonded to the citric acid; one of these acts as a phenolic-OH hydrogen bond donor to the carbonyl of a carboxylic acid arm of citric acid. In contrast, the other phenolic-OH acts as a hydrogen bond acceptor from the quaternary C-OH of citric acid. © 2011 The Royal Society of Chemistry