Designing History

Strategist of landmark political campaigns from as far away as Liberia and as close as Baltimore City, Professor Larry Gibson takes images from his own storied past and Maryland history to paint a rich future

Photogrammar Project

The Photogrammar Project is a Yale University Public Humanities Project designed to offer an interactive web-based open source visualization platform for the one-hundred and sixty thousand photographs created by the federal government from 1935 to 1943 under the Farm Securities Administration and Office of War Information (FSA-OWI). The images offer an archive of American life that is a resource for students, academics, and the public at large. The interactive map will map the one-hundred and sixty thousand photographs over historical county and census data. Additionally, users will be given the tools to be able to construct statistical graphics and visualization from the data. For example, a user will be able to quickly plot the percentage of military images collected by month and location or see a gallery of share cropping images created in Georgia. The Photogrammar Project , all accompanying code and detailed documentation will be available to the public at large

Feminist Pedagogy in a Time of Coronavirus Pandemic

FemTechNet, a network of scholars, artists, and students working on, with, and at the borders of technology, science, and feminism, has a great deal of experience thinking about pedagogy and technology. We have produced real intimacy, vibrant classes, and insurgent pedagogy since 2012. The principles of our signature Distributed Open Collaborative Courses (DOCCs) are crucial (see below). In this time of crisis, we believe we need to think again, drawing the most power possible from the radical knowledges, tactics, and commitments of feminist pedagogies of past experience. We write while schools, colleges, and universities have closed in a cascade of fear and also care in the hope of minimizing coronavirus infections. Mandated social distancing is critical, but difficult emotionally to sustain. At the same time, almost all campus authorities are requiring that classes be moved to an “online environment” to maintain physical distance. Most institutions are offering complicated, highly corporate, and narrow advice about how to teach online. While rapid conversion to standardized and detached Silicon Valley-type approaches is the prominent option, we have learned how quality instruction takes time, connection, careful planning, collaborative approaches, and local know-how

Incidence of adult Huntington's disease in the UK: a UK-based primary care study and a systematic review.

OBJECTIVES: The prevalence of Huntington's disease (HD) recorded in the UK primary care records has increased twofold between 1990 and 2010. This investigation was undertaken to assess whether this might be due to an increased incidence. We have also undertaken a systematic review of published estimates of the incidence of HD. SETTING: Incident patients with a new diagnosis of HD were identified from the primary care records of the Clinical Practice Research Datalink (CPRD). The systematic review included all published estimates of the incidence of HD in defined populations. PARTICIPANTS: A total of 393 incident cases of HD were identified from the CPRD database between 1990 and 2010 from a total population of 9,282,126 persons. PRIMARY AND SECONDARY OUTCOME MEASURES: The incidence of HD per million person-years was estimated. From the systematic review, the extent of heterogeneity of published estimates of the incidence of HD was examined using the I(2) statistic. RESULTS: The data showed that the incidence of HD has remained constant between 1990 and 2010 with an overall rate of 7.2 (95% CI 6.5 to 7.9) per million person-years. The systematic review identified 14 independent estimates of incidence with substantial heterogeneity and consistently lower rates reported in studies from East Asia compared with those from Australia, North America and some--though not all--those from Europe. Differences in incidence estimates did not appear to be explained solely by differences in case ascertainment or diagnostic methods. CONCLUSIONS: The rise in the prevalence of diagnosed HD in the UK, between 1990 and 2010, cannot be attributed to an increase in incidence. Globally, estimates of the incidence of HD show evidence of substantial heterogeneity with consistently lower rates in East Asia and parts of Europe. Modifiers may play an important role in determining the vulnerability of different populations to expansions of the HD allele

Population-specific genetic modification of Huntington\u27s disease in Venezuela.

Modifiers of Mendelian disorders can provide insights into disease mechanisms and guide therapeutic strategies. A recent genome-wide association (GWA) study discovered genetic modifiers of Huntington\u27s disease (HD) onset in Europeans. Here, we performed whole genome sequencing and GWA analysis of a Venezuelan HD cluster whose families were crucial for the original mapping of the HD gene defect. The Venezuelan HD subjects develop motor symptoms earlier than their European counterparts, implying the potential for population-specific modifiers. The main Venezuelan HD family inherits HTT haplotype hap.03, which differs subtly at the sequence level from European HD hap.03, suggesting a different ancestral origin but not explaining the earlier age at onset in these Venezuelans. GWA analysis of the Venezuelan HD cluster suggests both population-specific and population-shared genetic modifiers. Genome-wide significant signals at 7p21.2-21.1 and suggestive association signals at 4p14 and 17q21.2 are evident only in Venezuelan HD, but genome-wide significant association signals at the established European chromosome 15 modifier locus are improved when Venezuelan HD data are included in the meta-analysis. Venezuelan-specific association signals on chromosome 7 center on SOSTDC1, which encodes a bone morphogenetic protein antagonist. The corresponding SNPs are associated with reduced expression of SOSTDC1 in non-Venezuelan tissue samples, suggesting that interaction of reduced SOSTDC1 expression with a population-specific genetic or environmental factor may be responsible for modification of HD onset in Venezuela. Detection of population-specific modification in Venezuelan HD supports the value of distinct disease populations in revealing novel aspects of a disease and population-relevant therapeutic strategies

Catalogue of British Bronze Age axes, including basic typology, compositional analyses and associated radiocarbon dates

This archive lists ~8000 Bronze Age British axeheads, alongside associated compositional analyses, isotopic measurements and radiocarbon dates. It integrates several major existing data collection efforts and published catalogues, whilst also providing a self-consistent basic typology. It is archived as four related flat-sheet text files and could be reused to support quantitative assessment of geographic and temporal patterns in metalwork style, deposition, recovery, hoard co-occurrence and/or metallurgical compositions to name just a few salient topics

Comprehensive defect suppression in perovskite nanocrystals for high-efficiency light-emitting diodes

Electroluminescence efficiencies of metal halide perovskite nanocrystals (PNCs) are limited by a lack of material strategies that can both suppress the formation of defects and enhance the charge carrier confinement. Here we report a one-dopant alloying strategy that generates smaller, monodisperse colloidal particles (confining electrons and holes, and boosting radiative recombination) with fewer surface defects (reducing non-radiative recombination). Doping of guanidinium into formamidinium lead bromide PNCs yields limited bulk solubility while creating an entropy-stabilized phase in the PNCs and leading to smaller PNCs with more carrier confinement. The extra guanidinium segregates to the surface and stabilizes the undercoordinated sites. Furthermore, a surface-stabilizing 1,3,5-tris(bromomethyl)-2,4,6-triethylbenzene was applied as a bromide vacancy healing agent. The result is highly efficient PNC-based light-emitting diodes that have current efficiency of 108 cd A−1 (external quantum efficiency of 23.4%), which rises to 205 cd A−1 (external quantum efficiency of 45.5%) with a hemispherical len