The cultural dimensions of information use: A focus on the experience of Emirati students in higher education

Upon transitioning to higher education, Emirati students bring their cultural values and sentiments into the teaching and learning environment. Using the Explanatory Sequential component of the mixed methods approach, this research focused on Emirati students enrolled in higher education. The exploration of national culture revealed insights into how information use is experienced. This research provides empirical data contributing to the discussion of how culture intersects with information use in higher education. New contributions underpin the relationship between culture and information use. They also support the design and implementation of pedagogical approaches that recognize the cultural diversity of learners

Spectral cities: Death and living memories in the dark tourism of British ghost walks

This article explores the role played by ghost walks in imparting and enlivening the histories of cities for tourists. Drawing upon research in York, London, Brighton and Edinburgh the paper explores the manner in which the uncanny nature of the topic allows ghost walks to behave differently to other forms of dark tourism or thanatourism (Lennon and Foley, 2000; Seaton, 1996). Despite dealing with death and tragedy like other forms of dark tourism, the existence of ghosts within narratives allows for tragic history to be narrativised and performed by tour guides in a way that transforms the experience and embeds it within the cityscape anchoring memories and history to particular spaces, even long after a city has changed. Through tales of death the city’s history is brought to life, but in a manner that is more entertaining than mournful due to the facilitation of the uncanny nature of ghosts

Radio Observations as a Tool to Investigate Shocks and Asymmetries in Accreting White Dwarf Binaries

This dissertation uses radio observations with the Karl G. Jansky Very Large Array (VLA) to investigate the mechanisms that power and shape accreting white dwarfs (WD) and their ejecta. We test the predictions of both simple spherical and steady-state radio emission models by examining nova V1723 Aql, nova V5589 Sgr, symbiotic CH Cyg, and two small surveys of symbiotic binaries. First, we highlight classical nova V1723 Aql with three years of radio observations alongside optical and X-ray observations. We use these observations to show that multiple outflows from the system collided to create early non-thermal shocks with a brightness temperature of ⪆10⁶ K. While the late-time radio light curve is roughly consistent an expanding thermal shell of mass 2x10⁻⁴ M ⊙ solar masses, resolved images of V1723 Aql show elongated material that apparently rotates its major axis over the course of 15 months, much like what is seen in gamma-ray producing nova V959 Mon, suggesting similar structures in the two systems. Next, we examine nova V5589 Sgr, where we find that the early radio emission is dominated by a shock-powered non-thermal flare that produces strong (kTₓ > 33 keV) X-rays. We additionally find roughly 10⁻⁵ M⊙ solar masses of thermal bremsstrahlung emitting material, all at a distance of ~4 kpc. The similarities in the evolution of both V1723 Aql and V5589 Sgr to that of nova V959 Mon suggest that these systems may all have dense equatorial tori shaping faster flows at their poles. Turning our focus to symbiotic binaries, we first use our radio observations of CH Cyg to link the ejection of a collimated jet to a change of state in the accretion disk. We additionally estimate the amount of mass ejected during this period (10⁻⁷ M⊙ masses), and improve measurements of the period of jet precession (P=12013 +/- 74 days). We then use our survey of eleven accretion-driven symbiotic systems to determine that the radio brightness of a symbiotic system could potentially be used as an indicator of whether a symbiotic is powered predominantly by shell burning on the surface of the WD or by accretion. We additionally make the first ever radio detections of seven of the targets in our survey. Our survey of seventeen radio bright symbiotics, comparing observations before and after the upgrades to the VLA, shows the technological feasibility to resolve the nebulae of nearby symbiotic binaries, opening the door for new lines of research. We spatially resolve extended structure in several symbiotic systems in radio for the first time. Additionally, our observations reveal extreme radio variability in symbiotic BF Cyg before and after the production of a jet from the system. Our results from our surveys of symbiotics provide some support for the model of radio emission where the red giant wind is photoionized by the WD, and suggests that there may be a greater population of radio faint, accretion driven symbiotic systems. This work emphasizes the powerful nature of radio observations as a tool for understanding eruptive WD binaries and their outflows

Heralded quantum steering over a high-loss channel

Entanglement is the key resource for many long-range quantum information tasks, including secure communication and fundamental tests of quantum physics. These tasks require robust verification of shared entanglement, but performing it over long distances is presently technologically intractable because the loss through an optical fiber or free-space channel opens up a detection loophole. We design and experimentally demonstrate a scheme that verifies entanglement in the presence of at least $14.8\pm0.1$ dB of added loss, equivalent to approximately $80$ km of telecommunication fiber. Our protocol relies on entanglement swapping to herald the presence of a photon after the lossy channel, enabling event-ready implementation of quantum steering. This result overcomes the key barrier in device-independent communication under realistic high-loss scenarios and in the realization of a quantum repeater.Comment: 8 pages, 5 figure

Spectral cities: Death and living memories in the dark tourism of British ghost walks

This article explores the role played by ghost walks in imparting and enlivening the histories of cities for tourists. Drawing upon research in York, London, Brighton and Edinburgh the article explores the manner in which the uncanny nature of the topic allows ghost walks to behave differently to other forms of dark tourism or thanatourism (Lennon and Foley 2000, Seaton 1996). Despite dealing with death and tragedy like other forms of dark tourism, the existence of ghosts within narratives allows for tragic history to be narrativised and performed by tour guides in a way that transforms the experience and embeds it within the cityscape anchoring memories and history to particular spaces, even long after a city has changed. Through tales of death the city’s history is brought to life, but in a manner that is more entertaining than mournful due to the facilitation of the uncanny nature of ghosts

Queue-munity engagement: Collaborative Event Ethnography at the Antiques Roadshow in Kent

Using Collaborative Event Ethnography as a research method, a team of 21 researchers conducted fieldwork at the Antiques Roadshow in Ightham Mote, Kent. This article reflects on the experience of queuing at the event and how it was experienced and discussed by researchers and participants. Drawing upon Mol, the article approaches the practice of queuing as involving an inherent multiplicity of often contradictory experiences through which idealised, Second World War-related understandings of British queuing practice are simultaneously confirmed and challenged. Through multiple participants viewing the queue from within and outside we were able to capture the processes of community-building, curation, management, rule-maintenance and rule-bending within the social life of the queue. In demonstrating this multiplicity Collaborative Event Ethnography is shown to be an excellent research tool for capturing short-term, large-scale events while also highlighting the simultaneous simplicity and complexity of social interactions and social norms within queues

Delivery of temozolomide and N3-propargyl analog to brain tumors using an apoferritin nanocage

Glioblastoma multiforme (GBM) is a grade IV astrocytoma, which is the most aggressive form of brain tumor. The standard of care for this disease includes surgery, radiotherapy and temozolomide (TMZ) chemotherapy. Poor accumulation of TMZ at the tumor site, tumor resistance to drug, and dose-limiting bone marrow toxicity eventually reduce the success of this treatment. Herein, we have encapsulated >500 drug molecules of TMZ into the biocompatible protein nanocage, apoferritin (AFt), using a "nanoreactor" method (AFt-TMZ). AFt is internalized by transferrin receptor 1-mediated endocytosis and is therefore able to facilitate cancer cell uptake and enhance drug efficacy. Following encapsulation, the protein cage retained its morphological integrity and surface charge; hence, its cellular recognition and uptake are not affected by the presence of this cargo. Additional benefits of AFt include maintenance of TMZ stability at pH 5.5 and drug release under acidic pH conditions, encountered in lysosomal compartments. MTT assays revealed that the encapsulated agents displayed significantly increased antitumor activity in U373V (vector control) and, remarkably, the isogenic U373M (MGMT expressing TMZ-resistant) GBM cell lines, with GI50 values 500 molecules of the N3-propargyl imidazotetrazine analog (N3P), developed to combat TMZ resistance, and demonstrated significantly enhanced activity of AFt-N3P against GBM and colorectal carcinoma cell lines. These studies support the use of AFt as a promising nanodelivery system for targeted delivery, lysosomal drug release, and enhanced imidazotetrazine potency for treatment of GBM and wider-spectrum malignancies

The delirium and population health informatics cohort study protocol: ascertaining the determinants and outcomes from delirium in a whole population.

Background: Delirium affects 25% of older inpatients and is associated with long-term cognitive impairment and future dementia. However, no population studies have systematically ascertained cognitive function before, cognitive deficits during, and cognitive impairment after delirium. Therefore, there is a need to address the following question: does delirium, and its features (including severity, duration, and presumed aetiologies), predict long-term cognitive impairment, independent of cognitive impairment at baseline? Methods: The Delirium and Population Health Informatics Cohort (DELPHIC) study is an observational population-based cohort study based in the London Borough of Camden. It is recruiting 2000 individuals aged ≥70 years and prospectively following them for two years, including daily ascertainment of all inpatient episodes for delirium. Daily inpatient assessments include the Memorial Delirium Assessment Scale, the Observational Scale for Level of Arousal, and the Hierarchical Assessment of Balance and Mobility. Data on delirium aetiology is also collected. The primary outcome is the change in the modified Telephone Interview for Cognitive Status at two years. Discussion: DELPHIC is the first population sample to assess older persons before, during and after hospitalisation. The cumulative incidence of delirium in the general population aged ≥70 will be described. DELPHIC offers the opportunity to quantify the impact of delirium on cognitive and functional outcomes. Overall, DELPHIC will provide a real-time public health observatory whereby information from primary, secondary, intermediate and social care can be integrated to understand how acute illness is linked to health and social care outcomes