PeF: Poisson's Equation Based Large-Scale Fixed-Outline Floorplanning

Floorplanning is the first stage of VLSI physical design. An effective floorplanning engine definitely has positive impact on chip design speed, quality and performance. In this paper, we present a novel mathematical model to characterize non-overlapping of modules, and propose a flat fixed-outline floorplanning algorithm based on the VLSI global placement approach using Poisson's equation. The algorithm consists of global floorplanning and legalization phases. In global floorplanning, we redefine the potential energy of each module based on the novel mathematical model for characterizing non-overlapping of modules and an analytical solution of Poisson's equation. In this scheme, the widths of soft modules appear as variables in the energy function and can be optimized. Moreover, we design a fast approximate computation scheme for partial derivatives of the potential energy. In legalization, based on the defined horizontal and vertical constraint graphs, we eliminate overlaps between modules remained after global floorplanning, by modifying relative positions of modules. Experiments on the MCNC, GSRC, HB+ and ami49\_x benchmarks show that, our algorithm improves the average wirelength by at least 2\% and 5\% on small and large scale benchmarks with certain whitespace, respectively, compared to state-of-the-art floorplanners

Analytical Solution of Poisson's Equation with Application to VLSI Global Placement

Poisson's equation has been used in VLSI global placement for describing the potential field caused by a given charge density distribution. Unlike previous global placement methods that solve Poisson's equation numerically, in this paper, we provide an analytical solution of the equation to calculate the potential energy of an electrostatic system. The analytical solution is derived based on the separation of variables method and an exact density function to model the block distribution in the placement region, which is an infinite series and converges absolutely. Using the analytical solution, we give a fast computation scheme of Poisson's equation and develop an effective and efficient global placement algorithm called Pplace. Experimental results show that our Pplace achieves smaller placement wirelength than ePlace and NTUplace3. With the pervasive applications of Poisson's equation in scientific fields, in particular, our effective, efficient, and robust computation scheme for its analytical solution can provide substantial impacts on these fields

Residual Stress State in Single-Edge Notched Tension Specimen Caused by the Local Compression Technique

Three-dimensional (3D) finite element analyses (FEA) are performed to simulate the local compression (LC) technique on the clamped single-edge notched tension (SE(T)) specimens. The analysis includes three types of indenters, which are single pair of cylinder indenters (SPCI), double pairs of cylinder indenters (DPCI) and single pair of ring indenters (SPRI). The distribution of the residual stress in the crack opening direction in the uncracked ligament of the specimen is evaluated. The outcome of this study can facilitate the use of LC technique on SE(T) specimens

On the use of an explicit chemical mechanism to dissect peroxy acetyl nitrate formation.

Peroxy acetyl nitrate (PAN) is a key component of photochemical smog and plays an important role in atmospheric chemistry. Though it has been known that PAN is produced via reactions of nitrogen oxides (NOx) with some volatile organic compounds (VOCs), it is difficult to quantify the contributions of individual precursor species. Here we use an explicit photochemical model--Master Chemical Mechanism (MCM) model--to dissect PAN formation and identify principal precursors, by analyzing measurements made in Beijing in summer 2008. PAN production was sensitive to both NOx and VOCs. Isoprene was the predominant VOC precursor at suburb with biogenic impact, whilst anthropogenic hydrocarbons dominated at downtown. PAN production was attributable to a relatively small class of compounds including NOx, xylenes, trimethylbenzenes, trans/cis-2-butenes, toluene, and propene. MCM can advance understanding of PAN photochemistry to a species level, and provide more relevant recommendations for mitigating photochemical pollution in large cities

Phase-change nonlocal metasurfaces for dynamic wavefront manipulation

Recent advances in nonlocal metasurfaces have enabled unprecedented success in shaping the wavefront of light with spectral selectivity, offering new solutions for many emerging nanophotonics applications. The ability to tune both the spectral and spatial properties of such a novel class of metasurfaces is highly desirable, but the dynamic nonvolatile control remains elusive. Here, we demonstrate active narrowband wavefront manipulation by harnessing quasi-bound states in the continuum (quasi-BICs) in phase-change nonlocal metasurfaces. The proof-of-principle metasurfaces made of Sb$_2$S$_3$ allow for nonvolatile, reversible, and tunable spectral control over wavefront and switchable spatial response at a given wavelength. The design principle mainly builds upon the combination of the geometry phase of quasi-BICs and the dynamic tunability of phase-change meta-atoms to tailor the spatial response of light at distinct resonant wavelengths. By tuning the crystallization level of Sb$_2$S$_3$ meta-atoms, the dynamic nonlocal wavefront-shaping functionalities of beam steering, 1D, and 2D focusing are achieved. Furthermore, we demonstrate tunable holographic imaging with active spectral selectivity using our phase-change nonlocal metasurface. This work represents a critical advance towards developing integrated dynamic nonlocal metasurface for future augmented and virtual reality wearables

circFBXW7 attenuates malignant progression in lung adenocarcinoma by sponging miR-942-5p

Background: As a type of non-coding RNA, circular RNAs (circRNAs) are considered to be functional molecules associated with human cancers. An increasing number of circRNAs have been verified in malignant progression in a number of cancers. The circRNA, circFBXW7, has been proven to play an important role in tumor proliferation and metastasis. However, whether circFBXW7 influences progression in lung adenocarcinoma (LUAD) remains unclear. Methods: Quantitative real-time reverse transcriptase PCR (qRT-PCR) was used to verify circFBXW7 in LUAD cell lines and LUAD tissues. Kaplan-Meier analysis was then used to compare the disease-free survival (DFS) and overall survival (OS) of these LUAD patients. The biological function of circFBXW7 was examined by overexpression and knockdown of circFBXW7 using MTT assay, EdU assay, wound-healing assay, and Transwell in vitro assays. To explore the mechanism of the circFBXW7, RNA pull-down assay, dual luciferase reporter assay, and RNA immunoprecipitation (RIP) assay were employed to examine the interaction between circFBXW7 and miR-942-5p. Western blot was used to study the fundamental proteins associated with the epithelial-mesenchymal transition (EMT) pathway. In vivo studies with BALB/c nude mice subcutaneously injected with cells stably overexpressing circFBXW7 were performed to further validate the in vitro results. Results: circFBXW7 was downregulated in LUAD cell lines and tissues, and LUAD patients with lower levels had shorter DFS and OS. The in vitro study showed that circFBXW7 overexpression inhibited proliferation and migration of A549 and HCC2279 cell lines. These results were confirmed by circFBXW7 knockdown, which showed the reverse effect. The in vivo model showed that the circRNA levels influenced the tumor growth. Finally, we determined that circFBXW7 target miRNA-942-5p which regulates the EMT gene BARX2. The modulation of circFBXW7 levels produced significant changes in EMT genes in vitro and in vivo. Conclusions: Our findings showed that circFBXW7 inhibits proliferation and migration by controlling the miR-942-5p/BARX2 axis in LUAD cell lines and its levels correlates with patient survival suggesting that regulating circFBXW7 could have therapeutic value in treating LUAD patients

Refined drift chamber simulation in the CEPC experiment

The Circular Electron Positron Collider (CEPC) is a future experiment aimed at studying the properties of the Higgs boson with high precision. This requires excellent track reconstruction and particle identification (PID) performance, which is achieved in the 4th conceptual detector design of the CEPC experiments by combining a silicon tracker and a drift chamber. The drift chamber not only improves track reconstruction but also provides excellent PID with the cluster counting method. To evaluate the performance of this design accurately, a detailed simulation is necessary. In this paper, we present a refined drift chamber simulation by combining Geant4 and Garfield++. However, traditional waveform simulation using Garfield++ is extremely time-consuming, which motivates us to develop a fast waveform simulation method using a neural network. We validate the method using real data from the BESIII experiment. The results demonstrate the effectiveness of our approach and provide valuable insights for future experiments

Causal associations between human gut microbiota and osteomyelitis: a Mendelian randomization study

BackgroundRecent studies have emphasized the role of gut microbiota in the onset and progression of osteomyelitis. However, the exact types of gut microbiota and their mechanisms of action remain unclear. Additionally, there is a lack of theoretical support for treatments that improve osteomyelitis by altering the gut microbiota.MethodsIn our study, we utilized the largest genome-wide association study (GWAS) meta-analysis to date from the MiBioGen consortium, involving 13,400 participants. The GWAS data for osteomyelitis were sourced from the UK Biobank, which included 4,836 osteomyelitis cases and 486,484 controls. We employed a two-sample Mendelian randomization framework for a detailed investigation into the causal relationship between gut microbiota and osteomyelitis. Our methods included inverse variance weighting, MR-Egger, weighted median, and weighted mode approaches. Additionally, we applied Cochran’s Q statistic to assess the heterogeneity of the instrumental variable.ResultsAt the class level, Bacilli and Bacteroidia were positively correlated with the risk of osteomyelitis. At the order level, only Bacteroidales showed a positive association with osteomyelitis. At the genus level, an increased abundance of Butyricimonas, Coprococcus3, and Tyzzerella3 was positively associated with the risk of osteomyelitis, whereas Lachnospira was negatively associated. Sensitivity analyses showed no evidence of heterogeneity or pleiotropy.ConclusionThis study reveals that classes Bacilli and Bacteroidia, order Bacteroidales, and genera Butyricimonas, Coprococcus3, and Tyzzerella3 are implicated in increasing the risk of osteomyelitis, while the genus Lachnospira is associated with a reduced risk. Future investigations are warranted to elucidate the precise mechanisms through which these specific bacterial groups influence the pathophysiology of osteomyeliti