318 research outputs found
Autoentity: automated entity detection from massive text corpora
Entity detection is one of the fundamental tasks in Natural Language Processing and Information Retrieval. Most existing methods rely on human annotated data and hand-crafted linguistic features, which makes it hard to apply the model to an emerging domain. In this paper, we propose a novel automated entity detection framework, called AutoEntity, that performs automated phrase mining to create entity mention candidates and enforces lexico-syntactic rules to select entity mentions from candidates. Our experiments on real-world datasets in different domains and multiple languages have demonstrated the effectiveness and robustness of the proposed method
Analysis and design of a magnetically levitated planar motor with novel multilayer windings
This paper proposes a novel permanent magnet planar motor with moving multilayer orthogonal overlapping windings. This novel motor topology can achieve a five-degrees-of-freedom drive using two sets of x-direction windings and two sets of y-direction windings in a coreless configuration. The orthogonal multilayer construction guarantees a high utilization of the magnetic field and realizes decoupling between the x-direction thrust and the y-direction thrust. The topology and operating principle of the planar motor are introduced in this paper. The analytical modeling of the motor is established based on the equivalent current method, and the expressions of forces are derived. The force characteristics of the two-layer and three-layer winding topologies are compared, and the design guidelines of a planar motor are proposed. The analytical and 3-D finite-element model results are validated with the experimental results of a tested prototype
DiffusionMat: Alpha Matting as Sequential Refinement Learning
In this paper, we introduce DiffusionMat, a novel image matting framework
that employs a diffusion model for the transition from coarse to refined alpha
mattes. Diverging from conventional methods that utilize trimaps merely as
loose guidance for alpha matte prediction, our approach treats image matting as
a sequential refinement learning process. This process begins with the addition
of noise to trimaps and iteratively denoises them using a pre-trained diffusion
model, which incrementally guides the prediction towards a clean alpha matte.
The key innovation of our framework is a correction module that adjusts the
output at each denoising step, ensuring that the final result is consistent
with the input image's structures. We also introduce the Alpha Reliability
Propagation, a novel technique designed to maximize the utility of available
guidance by selectively enhancing the trimap regions with confident alpha
information, thus simplifying the correction task. To train the correction
module, we devise specialized loss functions that target the accuracy of the
alpha matte's edges and the consistency of its opaque and transparent regions.
We evaluate our model across several image matting benchmarks, and the results
indicate that DiffusionMat consistently outperforms existing methods. Project
page at~\url{https://cnnlstm.github.io/DiffusionMa
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Inhibition of chemotherapy resistant breast cancer stem cells by a ROR1 specific antibody.
Breast cancers enduring treatment with chemotherapy may be enriched for cancer stem cells or tumor-initiating cells, which have an enhanced capacity for self-renewal, tumor initiation, and/or metastasis. Breast cancer cells that express the type I tyrosine kinaselike orphan receptor ROR1 also may have such features. Here we find that the expression of ROR1 increased in breast cancer cells following treatment with chemotherapy, which also enhanced expression of genes induced by the activation of Rho-GTPases, Hippo-YAP/TAZ, or B lymphoma Mo-MLV insertion region 1 homolog (BMI1). Expression of ROR1 also enhanced the capacity of breast cancer cells to invade Matrigel, form spheroids, engraft in Rag2-/-[Formula: see text] mice, or survive treatment with paclitaxel. Treatment of mice bearing breast cancer patient-derived xenografts (PDXs) with the humanized anti-ROR1 monoclonal antibody cirmtuzumab repressed expression of genes associated with breast cancer stemness, reduced activation of Rho-GTPases, Hippo-YAP/TAZ, or BMI1, and impaired the capacity of breast cancer PDXs to metastasize or reengraft Rag2-/-[Formula: see text] mice. Finally, treatment of PDX-bearing mice with cirmtuzumab and paclitaxel was more effective than treatment with either alone in eradicating breast cancer PDXs. These results indicate that targeting ROR1 may improve the response to chemotherapy of patients with breast cancer
Presence of virus neutralizing antibodies in cerebral spinal fluid correlates with non-lethal rabies in dogs.
BACKGROUND: Rabies is traditionally considered a uniformly fatal disease after onset of clinical manifestations. However, increasing evidence indicates that non-lethal infection as well as recovery from flaccid paralysis and encephalitis occurs in laboratory animals as well as humans.
METHODOLOGY/PRINCIPAL FINDINGS: Non-lethal rabies infection in dogs experimentally infected with wild type dog rabies virus (RABV, wt DRV-Mexico) correlates with the presence of high level of virus neutralizing antibodies (VNA) in the cerebral spinal fluid (CSF) and mild immune cell accumulation in the central nervous system (CNS). By contrast, dogs that succumbed to rabies showed only little or no VNA in the serum or in the CSF and severe inflammation in the CNS. Dogs vaccinated with a rabies vaccine showed no clinical signs of rabies and survived challenge with a lethal dose of wild-type DRV. VNA was detected in the serum, but not in the CSF of immunized dogs. Thus the presence of VNA is critical for inhibiting virus spread within the CNS and eventually clearing the virus from the CNS.
CONCLUSIONS/SIGNIFICANCE: Non-lethal infection with wt RABV correlates with the presence of VNA in the CNS. Therefore production of VNA within the CNS or invasion of VNA from the periphery into the CNS via compromised blood-brain barrier is important for clearing the virus infection from CNS, thereby preventing an otherwise lethal rabies virus infection
Co-design Hardware and Algorithm for Vector Search
Vector search has emerged as the foundation for large-scale information
retrieval and machine learning systems, with search engines like Google and
Bing processing tens of thousands of queries per second on petabyte-scale
document datasets by evaluating vector similarities between encoded query texts
and web documents. As performance demands for vector search systems surge,
accelerated hardware offers a promising solution in the post-Moore's Law era.
We introduce \textit{FANNS}, an end-to-end and scalable vector search framework
on FPGAs. Given a user-provided recall requirement on a dataset and a hardware
resource budget, \textit{FANNS} automatically co-designs hardware and
algorithm, subsequently generating the corresponding accelerator. The framework
also supports scale-out by incorporating a hardware TCP/IP stack in the
accelerator. \textit{FANNS} attains up to 23.0 and 37.2 speedup
compared to FPGA and CPU baselines, respectively, and demonstrates superior
scalability to GPUs, achieving 5.5 and 7.6 speedup in median
and 95\textsuperscript{th} percentile (P95) latency within an eight-accelerator
configuration. The remarkable performance of \textit{FANNS} lays a robust
groundwork for future FPGA integration in data centers and AI supercomputers.Comment: 11 page
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