126 research outputs found
KAJIAN PARTISIPASI MASYARAKAT DALAM KEGIATAN PNPM MANDIRI DI KELURAHAN KLEAK KECAMATAN MALALAYANG KOTA MANADO
The research objective was to assess community participation in each phase of activity in the PNPM Urban at Kleak Village, Malalayang District of Manado City. The method used is qualitative method, which examines the public participation at every stage and sustainability of PNPM Urban. Informants in this study amounted to 5 people on the basis that they can represent the object under study, consisting of: Head of the village, the board of the Institute for Community Empowerment (LPM), Community Self-Supporting Agency, Project Management Team / TPK PNPM Mandiri, and community members. The results showed that people at KleakVillage participated in the implementation of each phase of activity PNPM. It is shown from the community who donated labor, materials and equipment to build their physical environment, but in contributing to the fund are indeed not all community memberwho voluntarily donate. The research conclude that in the process of planning the activities of the National Program for Community Empowerment (PNPM Urban Selfhelp) community in the Kleak Village, had participated fairly well. Kleak Village communities already participating in the implementation of PNPM it is seen from the community who donated labor, materials and equipment to build their physical environment, but in contributing to the fund are indeed some who voluntarily contribute
Antenatal corticosteroids impact the inflammatory rather than the antiangiogenic profile of women with preeclampsia
Circulating antiangiogenic factors and proinflammatory cytokines are implicated in the pathogenesis of preeclampsia. This study was performed to test the hypothesis that steroids modify the balance of inflammatory and proangiogenic and antiangiogenic factors that potentially contribute to the patient's evolving clinical state. Seventy singleton women, admitted for antenatal corticosteroid treatment, were enrolled prospectively. The study group consisted of 45 hypertensive women: chronic hypertension (n=6), severe preeclampsia (n=32), and superimposed preeclampsia (n=7). Normotensive women with shortened cervix (<2.5 cm) served as controls (n=25). Maternal blood samples of preeclampsia cases were obtained before steroids and then serially up until delivery. A clinical severity score was designed to clinically monitor disease progression. Serum levels of angiogenic factors (soluble fms-like tyrosine kinase-1 [sFlt-1], placental growth factor [PlGF], soluble endoglin [sEng]), endothelin-1 (ET-1), and proinflammatory markers (IL-6, C-reactive protein [CRP]) were assessed before and after steroids. Soluble IL-2 receptor (sIL-2R) and total immunoglobulins (IgG) were measured as markers of T- and B-cell activation, respectively. Steroid treatment coincided with a transient improvement in clinical manifestations of preeclampsia. A significant decrease in IL-6 and CRP was observed although levels of sIL-2R and IgG remained unchanged. Antenatal corticosteroids did not influence the levels of angiogenic factors but ET-1 levels registered a short-lived increase poststeroids. Although a reduction in specific inflammatory mediators in response to antenatal steroids may account for the transient improvement in clinical signs of preeclampsia, inflammation is unlikely to be the major contributor to severe preeclampsia or useful for therapeutic targeting. © 2014 American Heart Association, Inc
Dense matter with eXTP
In this White Paper we present the potential of the Enhanced X-ray Timing and
Polarimetry (eXTP) mission for determining the nature of dense matter; neutron
star cores host an extreme density regime which cannot be replicated in a
terrestrial laboratory. The tightest statistical constraints on the dense
matter equation of state will come from pulse profile modelling of
accretion-powered pulsars, burst oscillation sources, and rotation-powered
pulsars. Additional constraints will derive from spin measurements, burst
spectra, and properties of the accretion flows in the vicinity of the neutron
star. Under development by an international Consortium led by the Institute of
High Energy Physics of the Chinese Academy of Science, the eXTP mission is
expected to be launched in the mid 2020s.Comment: Accepted for publication on Sci. China Phys. Mech. Astron. (2019
Exuberant fibroblast activity compromises lung function via ADAMTS4
© 2020, The Author(s), under exclusive licence to Springer Nature Limited. Severe respiratory infections can result in acute respiratory distress syndrome (ARDS)1. There are no effective pharmacological therapies that have been shown to improve outcomes for patients with ARDS. Although the host inflammatory response limits spread of and eventually clears the pathogen, immunopathology is a major contributor to tissue damage and ARDS1,2. Here we demonstrate that respiratory viral infection induces distinct fibroblast activation states, which we term extracellular matrix (ECM)-synthesizing, damage-responsive and interferon-responsive states. We provide evidence that excess activity of damage-responsive lung fibroblasts drives lethal immunopathology during severe influenza virus infection. By producing ECM-remodelling enzymes—in particular the ECM protease ADAMTS4—and inflammatory cytokines, damage-responsive fibroblasts modify the lung microenvironment to promote robust immune cell infiltration at the expense of lung function. In three cohorts of human participants, the levels of ADAMTS4 in the lower respiratory tract were associated with the severity of infection with seasonal or avian influenza virus. A therapeutic agent that targets the ECM protease activity of damage-responsive lung fibroblasts could provide a promising approach to preserving lung function and improving clinical outcomes following severe respiratory infections
Publisher Correction: Exuberant fibroblast activity compromises lung function via ADAMTS4 (Nature, (2020), 587, 7834, (466-471), 10.1038/s41586-020-2877-5)
© 2020, The Author(s), under exclusive licence to Springer Nature Limited. An amendment to this paper has been published and can be accessed via a link at the top of the paper
Tracking the X-ray Polarization of the Black Hole Transient Swift J1727.8-1613 during a State Transition
We report on a campaign on the bright black hole X-ray binary Swift
J1727.81613 centered around five observations by the Imaging X-ray
Polarimetry Explorer (IXPE). This is the first time it has been possible to
trace the evolution of the X-ray polarization of a black hole X-ray binary
across a hard to soft state transition. The 2--8 keV polarization degree slowly
decreased from 4\% to 3\% across the five observations, but
remained in the North-South direction throughout. Using the Australia Telescope
Compact Array (ATCA), we measure the intrinsic 7.25 GHz radio polarization to
align in the same direction. Assuming the radio polarization aligns with the
jet direction (which can be tested in the future with resolved jet images),
this implies that the X-ray corona is extended in the disk plane, rather than
along the jet axis, for the entire hard intermediate state. This in turn
implies that the long (10 ms) soft lags that we measure with the
Neutron star Interior Composition ExploreR (NICER) are dominated by processes
other than pure light-crossing delays. Moreover, we find that the evolution of
the soft lag amplitude with spectral state differs from the common trend seen
for other sources, implying that Swift J1727.81613 is a member of a hitherto
under-sampled sub-population.Comment: Submitted to ApJ. 20 pages, 8 figure
Root-emitted volatile organic compounds: can they mediate belowground plant-plant interactions?
peer reviewedBackground
Aboveground, plants release volatile organic compounds (VOCs) that act as chemical
signals between neighbouring plants. It is now well documented that VOCs emitted by
the roots in the plant rhizosphere also play important ecological roles in the soil
ecosystem, notably in plant defence because they are involved in interactions between
plants, phytophagous pests and organisms of the third trophic level. The roles played
by root-emitted VOCs in between- and within-plant signalling, however, are still poorly
documented in the scientific literature.
Scope
Given that (1) plants release volatile cues mediating plant-plant interactions
aboveground, (2) roots can detect the chemical signals originating from their
neighbours, and (3) roots release VOCs involved in biotic interactions belowground,
the aim of this paper is to discuss the roles of VOCs in between- and within-plant
signalling belowground. We also highlight the technical challenges associated with the
analysis of root-emitted VOCs and the design of experiments targeting volatile-mediated
root-root interactions.
Conclusions
We conclude that root-root interactions mediated by volatile cues deserve more
research attention and that both the analytical tools and methods developed to study
the ecological roles played by VOCs in interplant signalling aboveground can be
adapted to focus on the roles played by root-emitted VOCs in between- and within-plant
signalling
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